Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lee-Way J"'
Autor:
Rebeca Scalco, Luca C. Oliveira, Zhengfeng Lai, Danielle J. Harvey, Lana Abujamil, Charles DeCarli, Lee-Way Jin, Chen-Nee Chuah, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Accurate and scalable quantification of amyloid-β (Aβ) pathology is crucial for deeper disease phenotyping and furthering research in Alzheimer Disease (AD). This multidisciplinary study addresses the current limitations on neuropathology
Externí odkaz:
https://doaj.org/article/db05312ca87d4aeab039bcdcaa3089b8
Autor:
Hsin-Pei Wang, Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Z. Huie, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Dan M. Mungas, Lee-Way Jin, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates comprehensive approaches to postmortem studies, including the representation of historically underrep
Externí odkaz:
https://doaj.org/article/2ccca9693bd8481a91ee168a49211a38
Autor:
Jacopo Di Lucente, Giuseppe Persico, Zeyu Zhou, Lee-Way Jin, Jon J. Ramsey, Jennifer M. Rutkowsky, Claire M. Montgomery, Alexey Tomilov, Kyoungmi Kim, Marco Giorgio, Izumi Maezawa, Gino A. Cortopassi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The Ketogenic Diet (KD) improves memory and longevity in aged C57BL/6 mice. We tested 7 months KD vs. control diet (CD) in the mouse Alzheimer’s Disease (AD) model APP/PS1. KD significantly rescued Long-Term-Potentiation (LTP) to wild-type
Externí odkaz:
https://doaj.org/article/5b5695c6167f4f8187ed0d0bf77fabd3
Autor:
Eduardo Z. Romo, Brian V. Hong, Rishi Y. Patel, Joanne K. Agus, Danielle J. Harvey, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Angela M. Zivkovic
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionThe role of lipopolysaccharide binding protein (LBP), an inflammation marker of bacterial translocation from the gastrointestinal tract, in Alzheimer’s disease (AD) is not clearly understood.MethodsIn this study the concentrations of LB
Externí odkaz:
https://doaj.org/article/2a111e9062b24c29a42865a9b2aca86c
Autor:
Rebeca Scalco, Naomi Saito, Laurel Beckett, My-Le Nguyen, Emily Huie, Hsin-Pei Wang, Delaney A. Flaherty, Lawrence S. Honig, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Despite the increasing demographic diversity of the United States’ aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease
Externí odkaz:
https://doaj.org/article/c400d7d0dfbe4c4d88b0540088c7067d
Autor:
Xinyu Tang, Jennyfer Tena, Jacopo Di Lucente, Izumi Maezawa, Danielle J. Harvey, Lee-Way Jin, Carlito B. Lebrilla, Angela M. Zivkovic
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Glycosylation has been found to be altered in the brains of individuals with Alzheimer’s disease (AD). However, it is unknown which specific glycosylation-related pathways are altered in AD dementia. Using publicly available RNA-seq datase
Externí odkaz:
https://doaj.org/article/b63938b1bd5e47a6983e6e45306c8391
H3G34-mutant diffuse hemispheric glioma with osseous metastases: a case report and literature review
Publikováno v:
CNS Oncology, Vol 12, Iss 2 (2023)
Aim: H3G34 diffuse hemispheric glioma is a CNS tumor that is difficult to diagnose and treat and accompanied with poor prognosis. It is becoming clear that extra CNS metastasis may present in a subset of patients with H3G34 gliomas, further complicat
Externí odkaz:
https://doaj.org/article/af882d13c8f7487fb05f4d4a28d47943
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
We postulate that myelin injury contributes to cholesterol release from myelin and cholesterol dysmetabolism which contributes to Abeta dysmetabolism, and combined with genetic and AD risk factors, leads to increased Abeta and amyloid plaques. Increa
Externí odkaz:
https://doaj.org/article/427b975ae14b4e37bc769ac1ad4a858e
Publikováno v:
Light: Science & Applications, Vol 10, Iss 1, Pp 1-13 (2021)
1700 nm optical coherence microscopy images neurons and axonal myelination across the mouse neocortex and some sub-cortical regions, based on intrinsic tissue contrast, with minimal invasiveness.
Externí odkaz:
https://doaj.org/article/94d84d6bcc9c4a578711a9f63bb19b31
Autor:
Oscar M. Muñoz Herrera, Brian V. Hong, Ulises Ruiz Mendiola, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Danielle J. Harvey, Angela M. Zivkovic
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10396 (2023)
Research has found that genes specific to microglia are among the strongest risk factors for Alzheimer’s disease (AD) and that microglia are critically involved in the etiology of AD. Thus, microglia are an important therapeutic target for novel ap
Externí odkaz:
https://doaj.org/article/470e8853b5e348d4b4958405a61020b9