Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lee-Tai Liu"'
Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors
Autor:
Lee Tai Liu, Shyh-Fong Chen, Chou Shan-Yen, Ying-Ta Wu, Tom S. Chen, Li-Rung Chen, Yi Wen Lin, Chih-Jung Kuo, Shin-Hun Juang, Yu-Chin Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract N-Substituted isatin derivatives have been prepared and their inhibition activities against SARS viral protease were evaluated.
N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides vi
N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205cb7fb3a4251b5c88984d5232bbb40
https://doi.org/10.1016/j.bmcl.2005.04.027
https://doi.org/10.1016/j.bmcl.2005.04.027
Autor:
Yuh-Sheng Wen, Hsiang-Ling Huang, Lee Tai Liu, Chia-Lin Jeff Wang, Shyh-Fong Chen, Pao-Chiung Hong
Publikováno v:
Tetrahedron: Asymmetry. 12:419-426
A convenient and practical method for the preparation of chiral 4-aryl-2-piperidinone from 3-arylglutaric anhydride and (S)-methylbenzylamine is described. Acylation or alkylation at the α-carbon of the chiral 4-aryl-2-piperidinone product afforded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48a0b9359954eb903d5c8ec7dba952d2
https://doi.org/10.1016/s0957-4166(01)00069-6
https://doi.org/10.1016/s0957-4166(01)00069-6
Publikováno v:
Tetrahedron: Asymmetry. 9:1637-1640
In the presence of a chiral BINAP–ruthenium(II) catalyst, asymmetric hydrogenation of β-keto propanoic acid N-methyl amide under 200 psi of hydrogen pressure furnished the corresponding 3-hydroxypropanoic acid N-methyl amide as the single enantiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a6fa00e79447a4e8f2c2cf52d86bef
https://doi.org/10.1016/s0957-4166(98)00158-x
https://doi.org/10.1016/s0957-4166(98)00158-x
Publikováno v:
Tetrahedron: Asymmetry. 7:3067-3070
A new series of chiral amino alcohols 3a-e has been prepared from natural amino acid L-cysteine. These compounds have been used as chiral ligands for borane reduction of ketones and for diethylzinc addition to aldehydes. In the reduction of ketones,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055d34330c328742f3c620648f783042
https://doi.org/10.1016/0957-4166(96)00399-0
https://doi.org/10.1016/0957-4166(96)00399-0
Publikováno v:
Nucleosides and Nucleotides. 12:941-949
Two representative S-cyclonucleosides, 8,5′-anhydro-2′, 3′-O-isopropylidene-8-mercaptoadenosine (3) and 8,2′-anhydro-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)-8-mercaptoguanosine (8), were prepared in good yields by dropwise addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38b1be7f6fcd474e9cd3cf3d18c3bb65
https://doi.org/10.1080/07328319308018564
https://doi.org/10.1080/07328319308018564
Publikováno v:
ChemInform. 28
A new series of chiral amino alcohols 3a-e has been prepared from natural amino acid L-cysteine. These compounds have been used as chiral ligands for borane reduction of ketones and for diethylzinc addition to aldehydes. In the reduction of ketones,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73736c2939b892e0fac5892cb7f7bdf
https://doi.org/10.1002/chin.199712035
https://doi.org/10.1002/chin.199712035
Publikováno v:
ChemInform. 29
In the presence of a chiral BINAP–ruthenium(II) catalyst, asymmetric hydrogenation of β-keto propanoic acid N-methyl amide under 200 psi of hydrogen pressure furnished the corresponding 3-hydroxypropanoic acid N-methyl amide as the single enantiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da039d972f333e7b6fd979f43f63b315
https://doi.org/10.1002/chin.199840076
https://doi.org/10.1002/chin.199840076
Publikováno v:
ChemInform. 32
α-Amino lactols 3 can be prepared in good yield and high optical purity by reduction of α-amino lactones 2 with lithium tri-tert-butoxyaluminohydride (LiAlH(O-t-Bu)3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04cb79b8143234226f53cf692d771eee
https://doi.org/10.1002/chin.200122040
https://doi.org/10.1002/chin.200122040
ChemInform Abstract: Asymmetric Syntheses of trans-3,4-Disubstituted 2-Piperidinones and Piperidines
Autor:
Shyh-Fong Chen, Hsiang-Ling Huang, Yuh-Sheng Wen, Lee Tai Liu, Chia-Lin Jeff Wang, Pao-Chiung Hong
Publikováno v:
ChemInform. 32
A convenient and practical method for the preparation of chiral 4-aryl-2-piperidinone from 3-arylglutaric anhydride and (S)-methylbenzylamine is described. Acylation or alkylation at the α-carbon of the chiral 4-aryl-2-piperidinone product afforded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb18c722a2b74d871d25e9968e94962
https://doi.org/10.1002/chin.200130143
https://doi.org/10.1002/chin.200130143
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(22)
A series of C-6 or C-3′ alkynyl-substituted 4-anilinoquinazoline derivatives was prepared straightforwardly by a Sonogashira reaction of the corresponding bromo-substituted 4-anilinoquinazolines. Bioactive assay of these compounds for in vitro EGFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b245569ced442cb17bd9600535619c
https://pubmed.ncbi.nlm.nih.gov/17889528
https://pubmed.ncbi.nlm.nih.gov/17889528