Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lee Zourelias"'
Autor:
Isabelle M.A. Lombaert, Vaishali N. Patel, Christina E. Jones, Derrick C. Villier, Ashley E. Canada, Matthew R. Moore, Elsa Berenstein, Changyu Zheng, Corinne M. Goldsmith, John A. Chorini, Daniel Martin, Lee Zourelias, Mark G. Trombetta, Paul C. Edwards, Kathleen Meyer, Dale Ando, Michael J. Passineau, Matthew P. Hoffman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 839-855 (2020)
Salivary gland hypofunction causes significant morbidity and loss of quality of life for head and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet therapeutic need. We used an adeno-associated virus serotype 2 (AAV2
Externí odkaz:
https://doaj.org/article/9043b0d9998246adb36e026172057354
Autor:
Ramaz Geguchadze, Zhimin Wang, Lee Zourelias, Paola Perez-Riveros, Paul C Edwards, Laurie Machen, Michael J Passineau
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
In this study, we compared gene transfer efficiency and host response to ultrasound-assisted, nonviral gene transfer with a conventional plasmid and a minicircle vector in the submandibular salivary glands of mice. Initially, we looked at gene transf
Externí odkaz:
https://doaj.org/article/c9e59ba853c0417e86452f58fa2def47
Autor:
Eric C. Shiao, Michael S. Halbreiner, Srinivas Murali, Michael J. Passineau, Cameron N. Riviere, Eric T. Rasmussen, Lee Zourelias
Publikováno v:
Int J Med Robot
BACKGROUND: HeartLander is a tethered robot walker that utilizes suction to adhere to the beating heart. HeartLander can be used for minimally invasive administration of cardiac medications or ablation of tissue. In order to administer injections saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c1348ec28cf37dae348e3c1cb14471
https://europepmc.org/articles/PMC8416707/
https://europepmc.org/articles/PMC8416707/
Autor:
Matthew P. Hoffman, Vaishali N. Patel, Mark G. Trombetta, Corinne M. Goldsmith, Dale Ando, Changyu Zheng, John A. Chorini, Christina E. Jones, Derrick C. Villier, Kathleen Meyer, Matthew Moore, Lee Zourelias, Paul C. Edwards, Elsa H. Berenstein, Isabelle M.A. Lombaert, Daniel Martin, Ashley E. Canada, Michael J. Passineau
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 839-855 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 839-855 (2020)
Salivary gland hypofunction causes significant morbidity and loss of quality of life for head and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet therapeutic need. We used an adeno-associated virus serotype 2 (AAV2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df7e0fe845f67178f7c17c484598867
https://pubmed.ncbi.nlm.nih.gov/32953934
https://pubmed.ncbi.nlm.nih.gov/32953934
Autor:
Lee Zourelias, Angela Sanguino, Changgong Wu, Kelly J. Shields, Ramaz Geguchadze, Zhimin Wang, Michael J Passineau, Kristin B. Highland, Raymond L. Benza
Publikováno v:
Human Gene Therapy. 28:681-689
Pulmonary arterial hypertension (PAH) is a progressive disease that culminates in right heart failure and death. Prostacyclin (PGI2) and its derivatives are effective treatments for PAH when administered as continuous parenteral infusions. This treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2991ac48329ceb2a2eee7627a65909da
https://doi.org/10.1089/hum.2017.040
https://doi.org/10.1089/hum.2017.040
Autor:
Kelly J. Shields, Raymond L. Benza, Lee Zourelias, Rong Chong, Kostas Verdelis, Erin M. Faight
Publikováno v:
Pulmonary Circulation
Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant vascular remodeling within the lung. Clinical computed tomography (CT) scans are routinely used to aid in PAH diagnosis. Animal models, including the Sugen-hypoxic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb92c6e2c839ae5b489f1a98b140d5a
http://europepmc.org/articles/PMC5467946
http://europepmc.org/articles/PMC5467946
Autor:
Kelly J. Shields, Erin M. Faight, Raymond L. Benza, Kostas Verdelis, Lee Zourelias, Michael J. Passineau, Changgong Wu, Rong Chong
Publikováno v:
Pulmonary Circulation. 6:586-596
Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant vascular remodeling. The obesity epidemic has produced great interest in the relationship between small visceral adipose tissue depots producing localized inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f31353edb00d79417c71c7070bbbf34
https://doi.org/10.1086/688931
https://doi.org/10.1086/688931
Autor:
Zhimin Wang, Lee Zourelias, Changgong Wu, Mark G. Trombetta, Michael J. Passineau, Paul C. Edwards
Publikováno v:
Gene therapy
Rationale Xerostomia is a common side effect of ionizing radiation used to treat head and neck cancer. A groundbreaking Phase I human clinical trial utilizing Adenoviral gene transfer of Aquaporin-1 (AQP1) to a single salivary gland of individuals su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fde9725e6baadcf7457edc85b3ee0d
http://europepmc.org/articles/PMC4560616
http://europepmc.org/articles/PMC4560616
Autor:
Jarrod W. Barnes, Richard Steet, Laurie Machen, Rachel Paul, Lee Zourelias, Olga A. Mamaeva, Timothy Fahrenholz, H.M. Kingston, Michael J. Passineau, Raymond L. Benza, Mary MacDougall, Katherine Nega
Publikováno v:
Human Gene Therapy. 22:293-301
Fabry disease is caused by an X-linked deficiency of the lysosomal enzyme α-galactosidase A (GLA) and has been treated successfully with enzyme replacement therapy (ERT). Gene therapy has been proposed as an alternative to ERT due to the presumed ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ca6e518a1066951304a7db1f83572f
https://doi.org/10.1089/hum.2010.069
https://doi.org/10.1089/hum.2010.069
Publikováno v:
Gene Therapy. 17:1318-1324
We report a non-viral gene transfer method using ultrasound induced microbubble destruction to allow the uptake of plasmid gene transfer vectors to the cells of the mouse salivary gland. The Luciferase (Luc) reporter gene, driven by a cytomegalovirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf9d12d4d43a2b58baebb70b8981cc6
https://doi.org/10.1038/gt.2010.86
https://doi.org/10.1038/gt.2010.86