Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lee T. Call"'
Autor:
Jason M. Foulks, Kent J. Carpenter, Bai Luo, Yong Xu, Anna Senina, Rebecca Nix, Ashley Chan, Adrianne Clifford, Marcus Wilkes, David Vollmer, Benjamin Brenning, Shannon Merx, Shuping Lai, Michael V. McCullar, Koc-Kan Ho, Daniel J. Albertson, Lee T. Call, Jared J. Bearss, Sheryl Tripp, Ting Liu, Bret J. Stephens, Alexis Mollard, Steven L. Warner, David J. Bearss, Steven B. Kanner
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 5, Pp 403-412 (2014)
The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells. PIM kinases act in down
Externí odkaz:
https://doaj.org/article/f6e9436c49d74639b522a5830ff2bb3f
Autor:
Steven L. Warner, Sunil Sharma, Susie Choi, Kent J. Carpenter, Hariprasad Vankayalapati, Jared Bearss, David J. Bearss, Lee T. Call, Ting Chen, Venkataswamy Sorna
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(24)
In this work, we describe the use of the rule of 3 fragment-based strategies from biochemical screening data of 1100 in-house, small, low molecular weight fragments. The sequential combination of in silico fragment hopping and fragment linking based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50253488baf845235c44451ac258a4f8
https://pubmed.ncbi.nlm.nih.gov/29150397
https://pubmed.ncbi.nlm.nih.gov/29150397
Autor:
David J. Bearss, Jared Bearss, Lee T. Call, Alexis Mollard, Shuping Lai, Steven L. Warner, Dan Albertson, Shannon Merx, Ashley Chan, Michael V. McCullar, Yong Xu, Rebecca N. Nix, Anna Senina, Marcus Wilkes, Ting Liu, Bret Stephens, Jason M. Foulks, Steven B. Kanner, David Vollmer, Kent J. Carpenter, Adrianne Clifford, Benjamin Brenning, Koc Kan Ho, Bai Luo, Sheryl R. Tripp
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 5, Pp 403-412 (2014)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells. PIM kinases act in down
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2152aee3dabac3beff14d5487b5fed47
Autor:
Jared Bearss, Steven L. Warner, Hariprasad Vankayalapati, Alexis Mollard, Mark Wade, Lee T. Call, David J. Bearss, Sunil Sharma, Anupam Verma
Publikováno v:
ACS medicinal chemistry letters. 2(12)
The receptor tyrosine kinase AXL has emerged in recent years as an potential oncology target due to its over expression in several types of cancers coupled with its ability to promote tumor growth and metastasis. In order to identify small molecule i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0679ef944b9744ec5178f07ca201528a
https://pubmed.ncbi.nlm.nih.gov/22247788
https://pubmed.ncbi.nlm.nih.gov/22247788
Autor:
Alexis Mollard, Jared Bearss, Alex Ober, Malia Anderson, Steven L. Warner, David J. Bearss, Sunil Sharma, Lee T. Call, Hariprasad Vankayalapati
Publikováno v:
Cancer Research. 73:5543-5543
Pancreatic cancer is virtually a uniformly lethal disease and a better understanding of the molecular basis of this malignancy is needed to discover new ways to prevent or treat this deadly disease. A central feature of malignant cells is their abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b181e57493150e7988b72f356dbc989
https://doi.org/10.1158/1538-7445.am2013-5543
https://doi.org/10.1158/1538-7445.am2013-5543
Autor:
Rachel A. Brog, Jessica Flory, Guido Tricot, David J. Bearss, Hariprasad Vankayalapati, Ling Yao Meng, Fenghuang Zhan, Lee T. Call
Publikováno v:
Cancer Research. 73:3391-3391
Drug resistance is a major complication in cancer therapy but the molecular mechanisms driving both innate and acquired drug resistance still remain largely unknown for many anti-cancer agents. Microarray analyses on paired primary multiple myeloma s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce27054c77585f1e7076c958cf18604
https://doi.org/10.1158/1538-7445.am2013-3391
https://doi.org/10.1158/1538-7445.am2013-3391
Autor:
Lee T. Call, Spencer Squire, Christopher Moreno, Brigham L. Bahr, David J. Bearss, Jenny Stevens, Alexis Mollard, Steven L. Warner, Bret Stephens
Publikováno v:
Cancer Research. 73:1875-1875
Rather than relying on oxidative phosphorylation for the generation of ATP, human tumor cells primarily utilize aerobic glycolysis to metabolize glucose (the Warburg effect). Pyruvate kinase is a metabolic enzyme that converts phosphoenolpyruvate (PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24e676d475ab5f454154604a3cb268f6
https://doi.org/10.1158/1538-7445.am2013-1875
https://doi.org/10.1158/1538-7445.am2013-1875
Abstract 4413: Mechanisms of sensitivity to treatment with the PDK1 inhibitors HCI-1680 and HCI-1708
Autor:
Sunil Sharma, Brian Walker, Lee T. Call, Hariprasad Vankayalapati, Sorna Venkataswamy, Steven L. Warner, David J. Bearss
Publikováno v:
Cancer Research. 73:4413-4413
The phosphoinositide-dependent kinase-1 (PDK1) is a serine/threonine kinase that has been considered a promising potential oncology drug target because of its role as an important regulator in the PI3K/AKT/mTOR pathway. PDK1 phosphorylates highly con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64d6d1d76e81d89b57db363fbdd42998
https://doi.org/10.1158/1538-7445.am2013-4413
https://doi.org/10.1158/1538-7445.am2013-4413
Autor:
Lee T. Call, Mark Wade, David J. Bearss, Jared Bearss, Mei Yang, Steven L. Warner, Anupam Verma, Alexis Mollard, Hariprasad Vankayalapati, Sunil Sharma, Marc D.H. Hansen
Publikováno v:
Cancer Research. 71:2577-2577
With the worst five-year survival rate of any cancer, pancreatic adenocarcinomas now rank as the fourth leading cause of cancer death in adults in the United States. This necessitates increased efforts to identify new leads that will serve as therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d337ba85cb7273d47596447775cca7de
https://doi.org/10.1158/1538-7445.am2011-2577
https://doi.org/10.1158/1538-7445.am2011-2577
Autor:
Sunil Sharma, David J. Bearss, Lee T. Call, Steven L. Warner, Sorna Venkataswamy, Hariprasad Vankayalapati
Publikováno v:
Cancer Research. 71:1368-1368
The PDK1 is a monomeric serine/threonine kinase and a promising oncology target of significant current interest for drug development due to its central role in the PI3K/AKT/mTOR pathway. It phosphorylates highly conserved Ser or Thr residues in the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2fb55b720620d291c11759d29b24ac
https://doi.org/10.1158/1538-7445.am2011-1368
https://doi.org/10.1158/1538-7445.am2011-1368