Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Lee Silverman"'
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Figure 1. Synthesis and pharmacokinetic characterization of AG-221. Supplementary Figure 2. Biochemical attributes of AG-221. Supplementary Figure 3. Biochemistry of AG-221 with respect to substrate and cofactor. Supplementary Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1
https://doi.org/10.1158/2159-8290.22531945.v1
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Table 1. Drug metabolism and pharmacokinetic attributes of AG-221. Supplementary Table 2. Selectivity of AG-221 confirmed by testing against a panel of kinases. Supplementary Table 3. Clinical characteristics of patients with IDH2R140Q-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936
https://doi.org/10.1158/2159-8290.22531936
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939
https://doi.org/10.1158/2159-8290.22531939
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 34K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd0a58f7cbd736328e57e7a23f7e5ec
https://doi.org/10.1158/1078-0432.22446309.v1
https://doi.org/10.1158/1078-0432.22446309.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2b8c17037133a1bc1c17abc8089fa3
https://doi.org/10.1158/1078-0432.c.6520713
https://doi.org/10.1158/1078-0432.c.6520713
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 27K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889d43f96b1d811fca5e3c164e018a19
https://doi.org/10.1158/1078-0432.22446306
https://doi.org/10.1158/1078-0432.22446306
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737acec25fe2137ea4f1aa5f53a36c5
https://doi.org/10.1158/1078-0432.22446312.v1
https://doi.org/10.1158/1078-0432.22446312.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 36K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa6e54e4641152cddff0837b8a5697
https://doi.org/10.1158/1078-0432.22446315
https://doi.org/10.1158/1078-0432.22446315
Autor:
Jeffrey A. Ecsedy, Mark Manfredi, Katherine Galvin, Karthik Venkatakrishnan, Ole Petter Veiby, Stephen Tirrell, Bradley Stringer, Chris Simpson, Lee Silverman, Jodi Pappas, Hua Liu, Gary Gray, Laura Faron-Yowe, Hadi Danaee, Mengkun Zhang, Douglas Bowman, Bert ONeil, Corey J. Langer, Neal J. Meropol, Margaret von Mehren, Susana Rosello, Edith Rodriguez-Braun, Jordi Andreu, Elena Elez, Teresa Macarulla, Jeffrey R. Infante, Howard Burris, E. Claire Dees, Roger B. Cohen, Andres Cervantes, Josep Tabernero, Vaishali Shinde, Arijit Chakravarty
Supplementary Figure 2 from Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b55d8e6b42b33e9017f32e7cc7c8ab6
https://doi.org/10.1158/0008-5472.22386059
https://doi.org/10.1158/0008-5472.22386059
Autor:
Jeffrey A. Ecsedy, Mark Manfredi, Katherine Galvin, Karthik Venkatakrishnan, Ole Petter Veiby, Stephen Tirrell, Bradley Stringer, Chris Simpson, Lee Silverman, Jodi Pappas, Hua Liu, Gary Gray, Laura Faron-Yowe, Hadi Danaee, Mengkun Zhang, Douglas Bowman, Bert ONeil, Corey J. Langer, Neal J. Meropol, Margaret von Mehren, Susana Rosello, Edith Rodriguez-Braun, Jordi Andreu, Elena Elez, Teresa Macarulla, Jeffrey R. Infante, Howard Burris, E. Claire Dees, Roger B. Cohen, Andres Cervantes, Josep Tabernero, Vaishali Shinde, Arijit Chakravarty
Supplementary Tables 1-5 from Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bf0bdc7eb5070d39976f349ddec62a
https://doi.org/10.1158/0008-5472.22386053
https://doi.org/10.1158/0008-5472.22386053