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Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells.

Autor: Autio MI; Laboratory of Molecular Epigenomics and Chromatin Organization, Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, Singapore, Singapore.; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Singapore, Singapore., Motakis E; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, Singapore, Singapore., Perrin A; Laboratory of Molecular Epigenomics and Chromatin Organization, Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, Singapore, Singapore., Bin Amin T; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Singapore, Singapore., Tiang Z; Laboratory of Molecular Epigenomics and Chromatin Organization, Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, Singapore, Singapore., Do DV; Laboratory of Molecular Epigenomics and Chromatin Organization, Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, Singapore, Singapore., Wang J; Laboratory of RNA Genomics and Structure, Genome Institute of Singapore, Singapore, Singapore., Tan J; Center for Genome Diagnostics, Genome Institute of Singapore, Singapore, Singapore., Ding SSL; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore., Tan WX; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lee CJM; Laboratory of Molecular Epigenomics and Chromatin Organization, Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Precision Medicine Translational Research Programme, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Foo RSY; Laboratory of Molecular Epigenomics and Chromatin Organization, Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, Singapore, Singapore.

Publikováno v: ELife [Elife] 2024 Jan 02; Vol. 13. Date of Electronic Publication: 2024 Jan 02.

Neuronal hyperactivity-induced oxidant stress promotes in vivo α-synuclein brain spreading.

Autor: Helwig M; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Ulusoy A; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA., Rollar A; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., O'Sullivan SA; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Lee SSL; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Aboutalebi H; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Pinto-Costa R; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Jevans B; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Klinkenberg M; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Di Monte DA; German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.

Publikováno v: Science advances [Sci Adv] 2022 Sep 02; Vol. 8 (35), pp. eabn0356. Date of Electronic Publication: 2022 Aug 31.

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.

Autor: Low BSJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lim CS; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Ding SSL; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tan YS; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Krishnan VG; Molecular Engineering Lab (MEL), IMCB, A*STAR, Singapore, Singapore., Ang SF; Khoo Teck Puat Hospital, Singapore, Singapore., Neo CWY; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Verma CS; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Hoon S; Molecular Engineering Lab (MEL), IMCB, A*STAR, Singapore, Singapore., Lim SC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat Hospital, Singapore, Singapore., Tai ES; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. ateo@imcb.a-star.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ateo@imcb.a-star.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2021 May 25; Vol. 12 (1), pp. 3133. Date of Electronic Publication: 2021 May 25.

Empowering Mesenchymal Stem Cells for Ocular Degenerative Disorders.

Autor: Ding SSL; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. suetlee.ding@gmail.com., Subbiah SK; Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. rachelmok2005@gmail.com.; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. rachelmok2005@gmail.com.; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. rachelmok2005@gmail.com., Khan MSA; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. safwan.aucp@gmail.com.; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas University, College Station, Texas 77843, USA. safwan.aucp@gmail.com., Farhana A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, P.O. Box 2014, Aljouf Province, Saudi Arabia. 512@gmail.com., Mok PL; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. sureshkudsc@gmail.com.; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. sureshkudsc@gmail.com.; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, P.O. Box 2014, Aljouf Province, Saudi Arabia. sureshkudsc@gmail.com.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2019 Apr 10; Vol. 20 (7). Date of Electronic Publication: 2019 Apr 10.