Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lee S. Stewart"'
Autor:
O. Carter Snead, Lee S. Stewart, Miguel A. Cortez, Liqing Shen, Chun Che Liu, Xiaomei Wang, Jose Luis Perez Velazquez, Ying Wu
Publikováno v:
Pharmacology Biochemistry and Behavior. 94:124-130
The objective of the current study was to determine the origin of the slow spike and wave discharges (SSWD) in the transgenic mouse with postnatal over-expression of the GABA(B) receptor subunit R1a (GABA(B)R1a(tg)), a mutant animal with a characteri
Autor:
Katherine R, George, Timothy, Rico, Linda S, St-Pierre, Mathieu J, Dupont, Matthew J, Dupont, Christopher G, Blomme, Angelo, Mazzuchin, Lee S, Stewart, Michael A, Persinger
Publikováno v:
Epilepsy & Behavior. 15:98-105
Approximately 1 year after rats were seized as young adults with lithium (3 mEq/kg) and pilocarpine (30 mg/kg) and given acepromazine or ketamine, 18 blood measures, wet tissue weights, and detailed damage scores for 107 brain structures were complet
Autor:
Ilyas S. Aleem, Hamid Reza Sadeghnia, Liqing Shen, O. Carter Snead, Catherine H. Trepanier, Ying Wu, Chen Chu Liu, Miguel A. Cortez, Asim Ashraf, Ashlin Kanawaty, Lee S. Stewart
Publikováno v:
Pediatric Research. 65:499-503
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hyp
Publikováno v:
Behavior Genetics. 37:388-398
Disruption of the sleep-wake cycle has been reported among individuals with Down syndrome (DS). Here we studied behavioral rhythms in adult male and female Ts65Dn mice, a model of DS. The overall behavioral activity of Ts65Dn and diploid (2N) litterm
Autor:
Lee S. Stewart, Michael A. Persinger
Publikováno v:
Epilepsy & Behavior. 2:585-591
Permanent cognitive impairment is common following status epilepticus (SE) in both humans and animals. We examined the effect of the NMDA antagonist ketamine administered after SE onset on two forms of associative learning in the rat: conditioned tas
Publikováno v:
Epilepsy Research. 44:207-212
The efficacy of the cholinergic agonist pilocarpine to evoke generalized seizures in rats was examined over the 24-h photocycle. Both seizure latency and severity during the 24-h period exhibited marked diurnal variation. Seizure activity generalized
Autor:
Lee S. Stewart
Publikováno v:
International Journal of Neuroscience. 107:77-85
In human epilepsy, diurnal variation in seizure phenomena suggests the involvement of a time-dependent biological signal. Clinical evidence indicates that in some cases, temporal clustering of epileptic seizures is in phase with the nocturnal rise in
Autor:
Lee S. Stewart, Michael A. Persinger
Publikováno v:
International Journal of Neuroscience. 100:91-98
The effect of weak electromagnetic stimulation on the emergence of conditioned analgesia was examined in the adult rat. Subjects were conditioned to associate a continuous 20 kHz ultrasonic tone (CS) with 0.2 mA footshock (UCS-) over five successive
Autor:
Lee S. Stewart
Publikováno v:
International Journal of Neuroscience. 103:19-23
Male rats were exposed to a low-intensity (300-500 nT) electromagnetic (EM) field designed to simulate primed burst potentiation (PB) for 30 min preceding a one-trial olfactory learning task involving two brief encounters with a juvenile rat during a
Publikováno v:
The International journal of neuroscience. 122(8)
Atypical absence seizures are drug resistant in the majority of children with Lennox-Gastaut syndrome and herald a poor neurodevelopmental outcome. Here we studied the effects of environmental enrichment, enriched housing conditions designed to stimu