Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lee S. Leavitt"'
Autor:
Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak
Publikováno v:
Marine Drugs, Vol 22, Iss 3, p 118 (2024)
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investig
Externí odkaz:
https://doaj.org/article/eb10793f322b4e929d26fb3a31f6499e
Autor:
Cheryl Dowell, Zhenjian Lin, Baldomero M. Olivera, Ronald W. Hughen, Randall T. Peterson, Albebson L. Lim, Jie Zhang, Kevin Chase, J. Michael McIntosh, Noemi D. Paguigan, Lee S. Leavitt, Eric W. Schmidt, Shrinivasan Raghuraman, Manju Karthikeyan, Christopher A. Reilly, Cassandra E. Deering-Rice, Jortan O. Tun, Alan R. Light
Publikováno v:
ACS Chem Neurosci
In our efforts to discover new drugs to treat pain, we identified molleamines A-E (1-5) as major neuroactive components of the sea slug, Pleurobranchus forskalii, and their prey, Didemnum molle, tunicates. The chemical structures of molleamines were
Autor:
Shrinivasan Raghuraman, Joshua P. Torres, Baldomero M. Olivera, Ronald W. Hughen, Manju Karthikeyan, Chang-Shan Niu, Kevin Chase, Zhenjian Lin, Alan R. Light, Marco Bortolato, Jie Zhang, Lee S. Leavitt, Lili Sun, Noemi D. Paguigan, Roberto Cadeddu, Eric W. Schmidt, Christopher A. Reilly
Publikováno v:
Journal of Medicinal Chemistry. 64:7033-7043
In a program to identify pain treatments with low addiction potential, we isolated five steroids, conosteroids A-E (1-5), from the hypobranchial gland of the mollusk Conus geographus. Compounds 1-5 were active in a mouse dorsal root ganglion (DRG) as
Autor:
Manju Karthikeyan, Jortan O. Tun, Kevin Chase, Lee S. Leavitt, Albebson L. Lim, Shrinivasan Raghuraman, Cheryl Dowell, Ronald W. Hughen, Alan R. Light, Baldomero M. Olivera, J. M. McIntosh, Jie Zhang, Noemi D. Paguigan, Eric W. Schmidt, Christopher A. Reilly, Zhenjian Lin, Cassandra E. Deering-Rice, Randall T. Peterson
In our efforts to discover new drugs to treat pain, we identified molleamines A-E (1-5) as major neuroactive components of the sea slug, Pleurobranchus forskalii and their prey, Didemnum molle tunicates. The chemical structures of molleamines were el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93867834e3506529c91e592477639ba
https://doi.org/10.1101/2021.05.17.444536
https://doi.org/10.1101/2021.05.17.444536
Autor:
Changshan, Niu, Lee S, Leavitt, Zhenjian, Lin, Noemi D, Paguigan, Lili, Sun, Jie, Zhang, Joshua P, Torres, Shrinivasan, Raghuraman, Kevin, Chase, Roberto, Cadeddu, Manju, Karthikeyan, Marco, Bortolato, Christopher A, Reilly, Ronald W, Hughen, Alan R, Light, Baldomero M, Olivera, Eric W, Schmidt
Publikováno v:
Journal of medicinal chemistry. 64(10)
In a program to identify pain treatments with low addiction potential, we isolated five steroids, conosteroids A-E (
Autor:
Tosifa A. Memon, Nicole Schmitt, Jackson Carter, Kevin Chase, Noemi D. Paguigan, Yannan Yan, Shrinivasan Raghuraman, Zhenjian Lin, Eric W. Schmidt, Albebson L. Lim, Christopher A. Reilly, Bo Hjorth Bentzen, Russell W. Teichert, Manju Karthikeyan, Baldomero M. Olivera, Lee S. Leavitt, Sean Christensen
Publikováno v:
Paguigan, N D, Yan, Y, Karthikeyan, M, Chase, K, Carter, J, Leavitt, L S, Lim, A L, Lin, Z, Memon, T, Christensen, S, Bentzen, B H, Schmitt, N, Reilly, C A, Teichert, R W, Raghuraman, S, Olivera, B M & Schmidt, E W 2021, ' The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons ', ACS chemical biology, vol. 16, no. 9, pp. 1654-1662 . https://doi.org/10.1021/acschembio.1c00328
Marine tunicates produce defensive amino-acid derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine (DIMTA), but their mechanisms of action are rarely known. Using an assay-guided approach, we found that out of the many different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9884ca44604783f84921e5567db85434
https://curis.ku.dk/ws/files/285240582/The_tunicate_metabolite_2_3_5_diiodo_4_methoxyphenyl_ethan_1_.pdf
https://curis.ku.dk/ws/files/285240582/The_tunicate_metabolite_2_3_5_diiodo_4_methoxyphenyl_ethan_1_.pdf
Autor:
Kevin Chase, Baldomero M. Olivera, Rocio K. Finol-Urdaneta, Lee S. Leavitt, Shrinivasan Raghuraman, Rishi K. Alluri, Russell W. Teichert, Heinrich Terlau, Mario J. Giacobassi
Publikováno v:
Proc Natl Acad Sci U S A
Somatosensory neurons have historically been classified by a variety of approaches, including structural, anatomical, and genetic markers; electrophysiological properties; pharmacological sensitivities; and more recently, transcriptional profile diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815d9404d444b0cd280516a5d3667176
https://europepmc.org/articles/PMC7071849/
https://europepmc.org/articles/PMC7071849/
Publikováno v:
Neuroscience. 353:76-86
The molecular sensor of innocuous (painless) cold sensation is well-established to be transient receptor potential cation channel, subfamily M, member 8 (TRPM8). However, the role of transient receptor potential cation channel, subfamily A, member 1
Autor:
David A. Köpfer, Bert L. de Groot, Lee S. Leavitt, Shrinivasan Raghuraman, Jie Song, Mario J. Giacobassi, Wojciech Kopec, Baldomero M. Olivera, Sönke Cordeiro, Rocio K. Finol-Urdaneta, Russell W. Teichert, Anna Markushina, Robert J. French, Heinrich Terlau
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The vast complexity of native heteromeric K+ channels is largely unexplored. Defining the composition and subunit arrangement of individual subunits in native heteromeric K+ channels and establishing their physiological roles is experimentally challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b297df0b829b645e0df87c679796086
https://hdl.handle.net/21.11116/0000-0002-B84E-821.11116/0000-0003-8F8C-F21.11116/0000-0002-E490-9
https://hdl.handle.net/21.11116/0000-0002-B84E-821.11116/0000-0003-8F8C-F21.11116/0000-0002-E490-9
Autor:
Sönke, Cordeiro, Rocio K, Finol-Urdaneta, David, Köpfer, Anna, Markushina, Jie, Song, Robert J, French, Wojciech, Kopec, Bert L, de Groot, Mario J, Giacobassi, Lee S, Leavitt, Shrinivasan, Raghuraman, Russell W, Teichert, Baldomero M, Olivera, Heinrich, Terlau
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(3)
The vast complexity of native heteromeric K(+) channels is largely unexplored. Defining the composition and subunit arrangement of individual subunits in native heteromeric K(+) channels and establishing their physiological roles is experimentally ch