Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lee S. Chong"'
Autor:
William C. Groutas, Radhika Venkataraman, Shu He, Yue He Li, Tien M. Truong, Qinghong Fu, Hongyi Yu, Nga T. Vu, Rongze Kuang, Juan Tu, Lee S. Chong, Sumei Ruan, Jeffrey B. Epp
Publikováno v:
Archives of Biochemistry and Biophysics. 385:162-169
The 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold (I) embodies a motif that allows it to dock to the active site of (chymo)trypsin-like proteases in a predictable and substrate-like fashion. Consequently, inhibitors derived from this heterocyclic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a418511bfdffd124f090d42df8d8698
https://doi.org/10.1006/abbi.2000.2139
https://doi.org/10.1006/abbi.2000.2139
Autor:
Lee S. Chong, Nadene Houser-Archield, Jeffrey B. Epp, Radhika Venkataraman, Rongze Kuang, He Huang, William C. Groutas, John R. Hoidal
Publikováno v:
Archives of Biochemistry and Biophysics. 332:335-340
Amino acid-derived phthalimide and saccharin derivatives have been investigated for their inhibitory activity toward the serine proteinases human leukocyte elastase, cathepsin G, and proteinase 3. The saccharin derivatives were found to be effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693f1b1ac46a2f375c186f3ec814c735
https://doi.org/10.1006/abbi.1996.0350
https://doi.org/10.1006/abbi.1996.0350
Asymmetric Synthesis of Calyculin C. 2. Synthesis of the C26−C37 Fragment and Model Wittig Couplings
Autor:
John E. Tellew, John Demattei, Gerard R. Scarlato, Anthony K. Ogawa, Lee S. Chong, Robert W. Armstrong
Publikováno v:
The Journal of Organic Chemistry. 61:6153-6161
We report our synthesis of the C(26)-C(37) fragment of serine/threonine protein phosphatase PP1 and PP2A inhibitor calyculin C (1). Outlined in this paper are synthetic approaches to the two components based on disconnection at the C(33)-N(3) amide b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437fe1016b33a4c2cc9b9816a06b14dc
https://doi.org/10.1021/jo960315q
https://doi.org/10.1021/jo960315q
Autor:
Lee S. Chong, Jeffrey B. Epp, Nadene Houser-Archield, Rongze Kuang, Radhika Venkataraman, John R. Hoidal, William C. Groutas
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:187-193
The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d6ca74b45d99b8c6adb12b77db0c41
https://doi.org/10.1016/0968-0896(95)00013-7
https://doi.org/10.1016/0968-0896(95)00013-7
Autor:
Eun-Hong Kim, Lee S. Chong, Radhika Venkataraman, Michael A. Stanga, Jeffrey B. Epp, William C. Groutas, James E. Yoder
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:125-128
A series of isoxazoline derivatives were synthesized and investigated for their in vitro inhibitory activity towards human leukocyte elastase, cathepsin G and proteinase 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62d04dda0ddee6f9f856363629d8414
https://doi.org/10.1016/0968-0896(95)00006-3
https://doi.org/10.1016/0968-0896(95)00006-3
Autor:
Lee S. Chong, Radhika Venkataraman, Jeffrey B. Epp, He Huang, Rongze Kuang, William C. Groutas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2745-2750
A general approach toward the design of mechanism-based inhibitors of serine proteinases involving the linking of fragment -CHX-COOR to an appropriate recognition element is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f531b2d1def647134870b066756e41
https://doi.org/10.1016/s0960-894x(01)80756-3
https://doi.org/10.1016/s0960-894x(01)80756-3
Publikováno v:
Biochemical and Biophysical Research Communications. 197:730-739
A series of heterocydic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one derivatives were found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c28aab479b118332245c293d475b4cc
https://doi.org/10.1006/bbrc.1993.2540
https://doi.org/10.1006/bbrc.1993.2540
Autor:
Radhika Venkataraman, William C. Groutas, He Huang, Jeffrey B. Epp, Lee S. Chong, Nadene Houser-Archield, Jerald J. McClenahan
Publikováno v:
Journal of Medicinal Chemistry. 36:3178-3181
A series of saccharin derivatives I has been synthesized and evaluated for their inhibitory activity toward human leukocyte elastase and cathepsin G. Most of the compounds were found to be efficient and time-dependent inhibitors of elastase. Inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a8b9a86cb28ded84330ecf597d71b1
https://doi.org/10.1021/jm00073a019
https://doi.org/10.1021/jm00073a019
Autor:
Michael A. Stanga, Jeffrey B. Epp, Lee S. Chong, William C. Groutas, Jerald J. McClenahan, Radhika Venkataraman, Michael J. Brubaker, F. Tagusagawa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1164:283-288
A series of 3-( alkylthio )-N- hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether side chain (compounds 1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::540c6b7189a0c443faec00a5d10c6acf
https://doi.org/10.1016/0167-4838(93)90260-x
https://doi.org/10.1016/0167-4838(93)90260-x
Autor:
Radhika Venkataraman, He Huang, Nadene Houser-Archield, Lee S. Chong, Jeffrey B. Epp, Jerald J. McClenahan, Rongze Kuang, Michael J. Brubaker, William C. Groutas
Publikováno v:
Biochemical and Biophysical Research Communications. 194:1491-1499
Neutrophil-derived mediators such as, for example, the serine proteinase elastase, cathepsin G and proteinase 3, play a critical role in inflammatory lung disease. This report describes the design, synthesis and in vitro inhibitory activity of some n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7684fefef7c072ee920afbe26f4475
https://doi.org/10.1006/bbrc.1993.1993
https://doi.org/10.1006/bbrc.1993.1993