Zobrazeno 1 - 10
of 829
pro vyhledávání: '"Lee S, Weinstein"'
Autor:
Liu Liu, Kimberley El, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia and plays a key role in the pathophysiology of diabetes. To stimulate the development of new classes of therapeutic agents targeting glucagon relea
Externí odkaz:
https://doaj.org/article/351c5d2d342f41a0a55bf933e3b5e318
Autor:
Liu Liu, Kimberley EI, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/90b54496c01f4db795d6cee6a571c9d1
Autor:
Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101780- (2023)
Objectives: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient a
Externí odkaz:
https://doaj.org/article/8509853fb6d444bb83dafa8e5ebf8337
Autor:
Jaroslawna Meister, Derek B. J. Bone, Jonas R. Knudsen, Luiz F. Barella, Thomas J. Velenosi, Dmitry Akhmedov, Regina J. Lee, Amanda H. Cohen, Oksana Gavrilova, Yinghong Cui, Gerard Karsenty, Min Chen, Lee S. Weinstein, Maximilian Kleinert, Rebecca Berdeaux, Thomas E. Jensen, Erik A. Richter, Jürgen Wess
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.
Externí odkaz:
https://doaj.org/article/59a46724f573486ab78cf2fe37925d04
Autor:
Lifan He, Hanlin Lu, Jianying Chu, Xiaoteng Qin, Jiangang Gao, Min Chen, Lee S. Weinstein, Jianmin Yang, Qunye Zhang, Cheng Zhang, Wencheng Zhang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Post-ischemic angiogenesis is a vital pathophysiological process in diseases such as peripheral arterial disease (PAD), heart ischemia, and diabetic retinopathy. The molecular mechanisms of post-ischemic angiogenesis are complicated and not fully elu
Externí odkaz:
https://doaj.org/article/c83e51bf850a4a8a88e478eee9d223e3
Autor:
Lifan He, Hanlin Lu, Xuyang Ji, Jianying Chu, Xiaoteng Qin, Min Chen, Lee S. Weinstein, Jiangang Gao, Jianmin Yang, Qunye Zhang, Cheng Zhang, Wencheng Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Endothelial cell leakage occurs in several diseases. Intracellular junctions and transcellular fashion are involved. The definite regulatory mechanism is complicated and not fully elucidated. The alpha subunit of the heterotrimeric G-stimulatory prot
Externí odkaz:
https://doaj.org/article/dd9ad3e2241e467482f7fbd1c849362a
Autor:
Chen Jiang, Ahsan Javed, Laura Kaiser, Michele M. Nava, Rui Xu, Dominique T. Brandt, Dandan Zhao, Benjamin Mayer, Javier Fernández-Baldovinos, Luping Zhou, Carsten Höß, Kovilen Sawmynaden, Arkadiusz Oleksy, David Matthews, Lee S. Weinstein, Heidi Hahn, Hermann-Josef Gröne, Peter L. Graumann, Carien M. Niessen, Stefan Offermanns, Sara A. Wickström, Thomas Worzfeld
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of
Externí odkaz:
https://doaj.org/article/c31e77abae1d4cc9839c925693d0c2fb
Autor:
Aisha A Tepede, James Welch, Maya Lee, Adel Mandl, Sunita K Agarwal, Naris Nilubol, Dhaval Patel, Craig Cochran, William F Simonds, Lee S Weinstein, Abhishek Jha, Corina Millo, Karel Pacak, Jenny E Blau
Publikováno v:
Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-9 (2020)
Pheochromocytoma (PHEO) in multiple endocrine neoplasia type 1 (MEN1) is extremely rare. The incidence is reported as less than 2%. We report a case of a 76-year-old male with familial MEN1 who was found to have unilateral PHEO. Although the patient
Externí odkaz:
https://doaj.org/article/5c31bb657ea149ef9970a42dd63bca38
Autor:
Jaroslawna Meister, Derek B.J. Bone, Jonas R. Knudsen, Luiz F. Barella, Liu Liu, Regina Lee, Oksana Gavrilova, Min Chen, Lee S. Weinstein, Maximilian Kleinert, Thomas E. Jensen, Jürgen Wess
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101415- (2022)
Objective: The goal of this study was to determine the glucometabolic effects of acute activation of Gs signaling in skeletal muscle (SKM) in vivo and its contribution to whole-body glucose homeostasis. Methods: To address this question, we studied m
Externí odkaz:
https://doaj.org/article/b7af00dabee84bf2ab4c1a70d19a36f4
Autor:
Berta Serra-Navarro, Rebeca Fernandez-Ruiz, Ainhoa García-Alamán, Marta Pradas-Juni, Eduardo Fernandez-Rebollo, Yaiza Esteban, Joan Mir-Coll, Julia Mathieu, Stephane Dalle, Max Hahn, Ulf Ahlgren, Lee S. Weinstein, Josep Vidal, Ramon Gomis, Rosa Gasa
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101264- (2021)
Objective: Early postnatal life is a critical period for the establishment of the functional β-cell mass that will sustain whole-body glucose homeostasis during the lifetime. β cells are formed from progenitors during embryonic development but unde
Externí odkaz:
https://doaj.org/article/9a142fddcdd54662a98fe0baba8cb82b