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Akademický článek

PEP-1–PIN1 Promotes Hippocampal Neuronal Cell Survival by Inhibiting Cellular ROS and MAPK Phosphorylation

Autor: Jung Hwan Park, Min Jea Shin, Gi Soo Youn, Hyeon Ji Yeo, Eun Ji Yeo, Hyun Jung Kwon, Lee Re Lee, Na Yeon Kim, Su Yeon Kwon, Su Min Kim, Yong-Jun Cho, Sung Ho Lee, Hyo Young Jung, Dae Won Kim, Won Sik Eum, Soo Young Choi

Publikováno v: Biomedicines, Vol 12, Iss 10, p 2352 (2024)

Background: The peptidyl-prolyl isomerase (PIN1) plays a vital role in cellular processes, including intracellular signaling and apoptosis. While oxidative stress is considered one of the primary mechanisms of pathogenesis in brain ischemic injury, t

Externí odkaz: https://doaj.org/article/23e43d1e220142889331a568b65d2956

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Akademický článek

Protective effects of cell permeable Tat-PIM2 protein on oxidative stress induced dopaminergic neuronal cell death

Autor: Min Jea Shin, Won Sik Eum, Gi Soo Youn, Jung Hwan Park, Hyeon Ji Yeo, Eun Ji Yeo, Hyun Jung Kwon, Eun Jeong Sohn, Lee Re Lee, Na Yeon Kim, Su Yeon Kwon, Su Min Kim, Hyo Young Jung, Duk-Soo Kim, Sung-Woo Cho, Oh-Shin Kwon, Dae Won Kim, Soo Young Choi

Publikováno v: Heliyon, Vol 9, Iss 5, Pp e15945- (2023)

Background: Oxidative stress is considered as one of the main causes of Parkinson's disease (PD), however the exact etiology of PD is still unknown. Although it is known that Proviral Integration Moloney-2 (PIM2) promotes cell survival by its ability

Externí odkaz: https://doaj.org/article/d4a80d4e08fc4caf98300a79b72be9b2

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Akademický článek

Tat-GSTpi Inhibits Dopaminergic Cells against MPP+-Induced Cellular Damage via the Reduction of Oxidative Stress and MAPK Activation

Publikováno v: Biomedicines, Vol 11, Iss 3, p 836 (2023)

Glutathione S-transferase pi (GSTpi) is a member of the GST family and plays many critical roles in cellular processes, including anti-oxidative and signal transduction. However, the role of anti-oxidant enzyme GSTpi against dopaminergic neuronal cel

Externí odkaz: https://doaj.org/article/cfeb9ae807604b90a48f4d87ffe4aacf

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Akademický článek

Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 3, p 2767 (2023)

Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischem

Externí odkaz: https://doaj.org/article/fc0aedb1cfb2463180e92c7570e3b6cb

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Akademický článek

PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson’s Disease

Autor: Yeon Joo Choi, Dae Won Kim, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Lee Re Lee, Yejin Song, Duk-Soo Kim, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Won Sik Eum, Soo Young Choi

Publikováno v: Molecules, Vol 26, Iss 11, p 3329 (2021)

Parkinson’s disease (PD) is characterized mainly by the loss of dopaminergic neurons in the substantia nigra (SN) mediated via oxidative stress. Although glutaredoxin-1 (GLRX1) is known as one of the antioxidants involved in cell survival, the effe

Externí odkaz: https://doaj.org/article/3f618c898e6f49f5acfebd9aa23cb8de

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