Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Lee R. Hagey"'
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100137- (2021)
Externí odkaz:
https://doaj.org/article/544ba47d2260494281c52b2c79c0a2a7
Autor:
Alan F. Hofmann, Lee R. Hagey
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 8, Pp 1553-1595 (2014)
During the last 80 years there have been extraordinary advances in our knowledge of the chemistry and biology of bile acids. We present here a brief history of the major achievements as we perceive them. Bernal, a physicist, determined the X-ray stru
Externí odkaz:
https://doaj.org/article/71574a5f9f2d477290ec5736da47ae67
Autor:
Michael Hiller, Bruce T. Schaar, Vahan B. Indjeian, David M. Kingsley, Lee R. Hagey, Gill Bejerano
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 817-823 (2012)
Genotype-phenotype mapping is hampered by countless genomic changes between species. We introduce a computational “forward genomics” strategy that—given only an independently lost phenotype and whole genomes—matches genomic and phenotypic los
Externí odkaz:
https://doaj.org/article/0c0f5bb7305e429abe00bf0c5ea37e0b
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 2, Pp 226-246 (2010)
Biliary bile salt composition of 677 vertebrate species (103 fish, 130 reptiles, 271 birds, 173 mammals) was determined. Bile salts were of three types: C27 bile alcohols, C27 bile acids, or C24 bile acids, with default hydroxylation at C-3 and C-7.
Externí odkaz:
https://doaj.org/article/5e0b7b86c5a042c695633ad6305ecae0
Autor:
Lee R. Hagey, Genta Kakiyama, Akina Muto, Takashi Iida, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Cleida A. Oliveira, Alan F. Hofmann
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 4, Pp 651-657 (2009)
The chemical structures of the three major bile acids present in the gallbladder bile of the Red-winged tinamou (Rhynchotus rufescens), an early evolving, ground-living bird related to ratites, were determined. Bile acids were isolated by preparative
Externí odkaz:
https://doaj.org/article/fadaeaf39e6f48db83e005db9b4df3bd
Autor:
Erica J. Reschly, Ni Ai, Sean Ekins, William J. Welsh, Lee R. Hagey, Alan F. Hofmann, Matthew D. Krasowski
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 7, Pp 1577-1587 (2008)
Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive evolutionary changes. We compared across species the bile sal
Externí odkaz:
https://doaj.org/article/75d08107df4b49baaeb229ee45e57336
Autor:
Genta Kakiyama, Hideyuki Tamegai, Takashi Iida, Kuniko Mitamura, Shigeo Ikegawa, Takaaki Goto, Nariyasu Mano, Junichi Goto, Peter Holz, Lee R. Hagey, Alan F. Hofmann
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 12, Pp 2682-2692 (2007)
The major bile acids present in the gallbladder bile of the common Australian wombat (Vombatus ursinus) were isolated by preparative HPLC and identified by NMR as the taurine N-acylamidates of chenodeoxycholic acid (CDCA) and 15α-hydroxylithocholic
Externí odkaz:
https://doaj.org/article/3958941c4b8d4677a6ad615348334063
Autor:
Ephraim Sehayek, Lee R. Hagey, Yee-Yan Fung, Elizabeth M. Duncan, Hannah J. Yu, Gösta Eggertsen, Ingemar Björkhem, Alan F. Hofmann, Jan L. Breslow
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 9, Pp 2020-2027 (2006)
An intercross between C57BL/6J and CASA/Rk mice was used to study the genetics of biliary bile acid composition. In parental strains, male C57BL/6J mice had significantly higher cholic acid (CA; 14%) and lower β-muricholic acid (βMC; 27%) than CASA
Externí odkaz:
https://doaj.org/article/d1aa8ae5867a44ae853af8cdf3ad74eb
Autor:
Genta Kakiyama, Takashi Iida, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara, Lee R. Hagey, Claudio D. Schteingart, Alan F. Hofmann
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 7, Pp 1551-1558 (2006)
By HPLC, a taurine-conjugated bile acid with a retention time different from that of taurocholate was found to be present in the bile of the black-necked swan, Cygnus melanocoryphus. The bile acid was isolated and its structure, established by 1H and
Externí odkaz:
https://doaj.org/article/083b75ed80bd4d7ebdd727dbd4753eab
Autor:
Antonio Moschetta, Fang Xu, Lee R. Hagey, Gerard P. van Berge-Henegouwen, Karel J. van Erpecum, Jos F. Brouwers, Jonathan C. Cohen, Molly Bierman, Helen H. Hobbs, Joseph H. Steinbach, Alan F. Hofmann
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2221-2232 (2005)
Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals), and individual phospholipid classes were measured in 35 species. All samples
Externí odkaz:
https://doaj.org/article/9632bad0da344203aa3682930e347105