Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lee P. Schacter"'
Autor:
Kenneth R. Hande, Dana S. Thompson, F. Anthony Greco, Antonius A. Miller, John D. Hainsworth, Sanjeev Kaul, Rashmi H. Barbhaiya, Nuggehally R. Srinivas, Linus N. Igwemezie, George C. Garrow, Lee P. Schacter
Publikováno v:
Clinical Pharmacology & Therapeutics. 57:499-507
Purpose To determine the maximum tolerated dose, toxicities, kinetics, and disposition of etoposide phosphate when administered as a daily 30-minute infusion for 5 days. Patients and methods Twenty-eight patients were enrolled in this phase I dose-es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140a9fa0a5b3b9ae1b481d7806051d37
https://doi.org/10.1016/0009-9236(95)90034-9
https://doi.org/10.1016/0009-9236(95)90034-9
Autor:
Linus N. Igwemezie, Mahmoud Seyedsadr, Eric Albert, Jacqueline Randolph, Lee P. Schacter, Pedro Santabarbara, Elizabeth A. Morgenthien
Publikováno v:
Cancer Chemotherapy and Pharmacology. 34:S58-S63
Etoposide phosphate (Etopophos, BMY-40481) is a water-soluble derivative of the widely used podophyllotoxin etoposide (VP-16). The phosphate ester renders the compound water-soluble, eliminating the need for formulation in polysorbate (Tween) 80, eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0ebff09ac369071250cd3f90a12d63
https://doi.org/10.1007/bf00684865
https://doi.org/10.1007/bf00684865
Autor:
TP Cooley, Renzo Canetta, Lee P. Schacter, Marcel Rozencweig, John S. Lambert, Raphael Dolin, Howard A. Liebman, JD Allan, Susan Kelley, Mohan Beltangady
Publikováno v:
Blood. 80:2969-2976
Myelosuppression is associated with human immunodeficiency virus (HIV) infection and may also be produced by agents used for the treatment of the disease or the treatment of its complications. Didanosine (ddl; 2′,3′-dideoxyinosine) is a newer pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ca3e607b714794782dd1fe3cee71ad
https://doi.org/10.1182/blood.v80.12.2969.2969
https://doi.org/10.1182/blood.v80.12.2969.2969
Autor:
Colin McLaren, Rashmi H. Barbhaiya, Mohan Beltangady, Michael Tsianco, Lisa M. Dunkle, Jitka K. Ritter, Renzo Canetta, Lee P. Schacter, Cathy Knupp, R. Russell Martin, Marcel Rozencweig, Claude Nicaise, Susan Kelley, Laurie Smaldone, Anne Cross
Publikováno v:
Clinical Infectious Diseases. 12:S570-S575
Ninety-two adult patients with AIDS or severe AIDS-related complex were treated with 2',3'-dideoxyinosine (didanosine; ddI) at dosages ranging from 0.8 to 66.0 mg/(kg.d) for at least 6 weeks in phase I trials. Potentially beneficial changes in weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c711b050fba6e78e38db0b56e3a9ea1
https://doi.org/10.1093/clinids/12.supplement_5.s570
https://doi.org/10.1093/clinids/12.supplement_5.s570
Autor:
Francois Letendre, David J. Stewart, Patty Hoogendoorn, Frances A. Shepherd, Elizabeth Eisenhauer, Glenwood D. Goss, Lee P. Schacter
Publikováno v:
Investigational New Drugs. 12:315-317
Elsamitrucin (BMY-28090) a novel fermentation product has demonstrated pre-clinical anti-tumour activity against a number of cell lines. The dose limiting toxicity in phase I studies was a reversible increase in hepatic transaminase. This study was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06afaa33aa25e9d5706139fee433c405
https://doi.org/10.1007/bf00873046
https://doi.org/10.1007/bf00873046
Autor:
S Z Fields, Kathleen Hock, Willi Kreis, Vincent Vinciguerra, Richard Ingram, Lee P. Schacter, Joann Baer, Daniel R. Budman
Publikováno v:
Cancer chemotherapy and pharmacology. 38(4)
Etoposide phosphate, a water soluble prodrug of etoposide, was evaluated at levels potentially useful in transplantation settings in patients with malignancies. For pharmacokinetic studies of etoposide phosphate in this phase I study, 21 patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bb77345792bb2a36b8c9e296f7d47d
https://pubmed.ncbi.nlm.nih.gov/8674162
https://pubmed.ncbi.nlm.nih.gov/8674162
Autor:
Alessandro M. Vannucchi, Kris Vaddi, Lee P. Schacter, Tiziano Barbui, Elisa Rumi, Reid Huber, Elisabetta Gattoni, Richard S. Levy, Elisabetta Antonioli, Nancy Contel, Lisa Pieri, Srdan Verstovsek, Edward C Bradley, Giovanni Barosi, Francesco Passamonti, William M. Garrett, Alessandro Rambaldi, Mario Cazzola, Peter J. Rosen, Hagop M. Kantarjian, Victor Sandor
Publikováno v:
Blood. 116:313-313
Abstract 313 Background: While advanced PV and ET patients at high thrombotic risk are managed primarily with HU, patients who are intolerant or refractory to HU have limited therapeutic options. Identification of a dominant gain-of-function mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfb6e402372ef164a10ec23c173b4393
https://doi.org/10.1182/blood.v116.21.313.313
https://doi.org/10.1182/blood.v116.21.313.313
Autor:
Regina Sisk, W. Angus Muir, Orrawin Trocki, James D. Ahlgren, Lee P. Schacter, John J. Gullo, Richard M. Goldberg
Publikováno v:
Cancer investigation. 9(1)
Forty four patients who had documented progression of metastatic colorectal cancer while receiving 5-fluorouracil (5-FU) monotherapy were treated with continuous infusion 5-FU, 300 mg/mg2/day, plus weekly low-dose cisplatin, 20 mg/m2. Treatment was g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0b9fe0775080778bfc00d043fd609f
https://pubmed.ncbi.nlm.nih.gov/2012994
https://pubmed.ncbi.nlm.nih.gov/2012994
Publikováno v:
Blood. 51:397-414
Sera from 26 patients with aplastic anemia (AA) were examined for their effects in vitro on autologous AA marrow and heterologous normal bone marrow proliferation. Two groups of patients with respect to serum activity were defined, one group (13 pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6123e43cb68a23f00abfb37ba3013727
https://doi.org/10.1182/blood.v51.3.397.397
https://doi.org/10.1182/blood.v51.3.397.397
Autor:
Claude Nicaise, Marcel Rozencweig, Renzo Canetta, Lee P. Schacter, Susan Kelley, Laurie Smaldone
Publikováno v:
Cancer treatment reviews. 16(1)
The use of megestrol acetate in treatment of malignancy (endometrial carcinoma, ovarian cancer, prostate cancer, breast cancer, renal cell carcinoma, malignant melanoma), endometrial hyperplasia, benign prostatic hypertrophy, contraception, anorexia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b94f81835828a3532d341d7195bbfea
https://pubmed.ncbi.nlm.nih.gov/2471590
https://pubmed.ncbi.nlm.nih.gov/2471590