Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Lee P Haynes"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 5 (2012)
The mammalian central nervous system (CNS) exhibits a remarkable ability to process, store and transfer information. Key to these activities is the use of highly regulated and unique patterns of calcium signals encoded by calcium channels and decoded
Externí odkaz:
https://doaj.org/article/3060d8db17b6408ba1234998ae2e9f1c
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17853 (2011)
The CaBPs represent a subfamily of small EF-hand containing calcium (Ca(2+))-sensing proteins related to calmodulin that regulate key ion channels in the mammalian nervous system. In a recent bioinformatic analyses we determined that CaBP7 and CaBP8
Externí odkaz:
https://doaj.org/article/8c90a54abc204c9bbf16b2d6c9dd7296
Autor:
Margaret E Graham, Gerald R Prescott, James R Johnson, Mathew Jones, Alice Walmesley, Lee P Haynes, Alan Morgan, Robert D Burgoyne, Jeff W Barclay
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17999 (2011)
Munc18-1 is an essential synaptic protein functioning during multiple stages of the exocytotic process including vesicle recruitment, docking and fusion. These functions require a number of distinct syntaxin-dependent interactions; however, Munc18-1
Externí odkaz:
https://doaj.org/article/c56eebfb9b8540b3b6a65436a2b5354b
Autor:
Lu-Yun Lian, Sravan R Pandalaneni, Pryank Patel, Hannah V McCue, Lee P Haynes, Robert D Burgoyne
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27779 (2011)
NCS-1 is a member of the neuronal calcium sensor (NCS) family of EF-hand Ca(2+) binding proteins which has been implicated in several physiological functions including regulation of neurotransmitter release, membrane traffic, voltage gated Ca(2+) cha
Externí odkaz:
https://doaj.org/article/7663008eff6b46ef85e295f245f701a2
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10534 (2010)
Neuronal calcium sensor-1 (NCS-1) is a Ca(2+) sensor protein that has been implicated in the regulation of various aspects of neuronal development and neurotransmission. It exerts its effects through interactions with a range of target proteins one o
Externí odkaz:
https://doaj.org/article/220cc48e786c490bbdbb9404cb4b02ee
Publikováno v:
Biochemical and biophysical research communications. 626
Mitosis, the accurate segregation of duplicated genetic material into what will become two new daughter cells, is accompanied by extensive membrane remodelling and membrane trafficking activities. Early in mitosis, adherent cells partially detach fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655f5324099e4e09dc7a9ca5f76b6cf6
https://pubmed.ncbi.nlm.nih.gov/35998546
https://pubmed.ncbi.nlm.nih.gov/35998546
Publikováno v:
Frontiers in Physiology. 13
The transformation of a single fertilised egg into an adult human consisting of tens of trillions of highly diverse cell types is a marvel of biology. The expansion is largely achieved by cell duplication through the process of mitosis. Mitosis is es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdc2d9d2dbf2d503d09edf749824bfa
https://doi.org/10.3389/fphys.2022.951979
https://doi.org/10.3389/fphys.2022.951979
Autor:
Ohm Prakash, Marie Held, Liam F. McCormick, Nitika Gupta, Lu-Yun Lian, Svetlana Antonyuk, Lee P. Haynes, N. Lowri Thomas, Nordine Helassa
Publikováno v:
Journal of Cell Science. 135
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition that can cause fatal cardiac arrhythmia. Human mutations in the Ca2+ sensor calmodulin (CaM) have been associated with CPVT susceptibility, suggesting that CaM dys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c098133c0e43a8ad5ef9cd20ebf775
https://doi.org/10.1242/jcs.258796
https://doi.org/10.1242/jcs.258796
Publikováno v:
The FASEB Journal
Mitosis defects can lead to premature ageing and cancer. Understanding mitosis regulation therefore has important implications for human disease. Early data suggested that calcium (Ca2+) signals could influence mitosis, but these have hitherto not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1949d0740de86fd9a73cea0b8e65ba4
http://europepmc.org/articles/PMC6910830
http://europepmc.org/articles/PMC6910830
Autor:
Alexei V. Tepikin, Michael Chvanov, Liam Pollock, Francesca De Faveri, Thomas Wileman, Svetlana Voronina, Ulrike Mayer, Danielle Moore, Ian A. Prior, Muhammad Awais, Alison J. Beckett, David N. Criddle, Lee P. Haynes, Robert Sutton
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Activation of trypsinogen (formation of trypsin) inside the pancreas is an early pathological event in the development of acute pancreatitis. In our previous studies we identified the activation of trypsinogen within endocytic vacuoles (EVs), cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7e06cd6788879b8d97d4d79d2bf216
https://pubmed.ncbi.nlm.nih.gov/31651224
https://pubmed.ncbi.nlm.nih.gov/31651224