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pro vyhledávání: '"Lee M. Shaughnessy"'
Publikováno v:
Cellular Microbiology. 8:781-792
Listeria monocytogenes (Lm) evade microbicidal defences inside macrophages by secreting a pore-forming cytolysin listeriolysin O (LLO), which allows Lm to escape vacuoles. LLO also inhibits Lm vacuole fusion with lysosomes, which indicates LLO alters
Autor:
Christine Alberti-Segui, Rebecca M. Henry, Joel A. Swanson, Darren E. Higgins, Lee M. Shaughnessy, Martin J. Loessner
Publikováno v:
Cellular Microbiology. 8:107-119
The bacterial pathogen Listeria monocytogenes (Lm) evades the antimicrobial mechanisms of macrophages by escaping from vacuoles to the cytosol, through the action of the cytolysin listeriolysin O (LLO). Because of heterogeneities in the timing and ef
Publikováno v:
Cellular Microbiology
Three proteins secreted by Listeria monocytogenes facilitate escape from macrophage vacuoles: the cholesterol-dependent cytolysin listeriolysin O (LLO), a phosphoinositide-specific phospholipase C (PI-PLC) and a broad-range phospholipase C (PC-PLC).
Autor:
Amy Herring-Palmer, Gary B. Huffnagle, Philip C. Hanna, Brian J. Heffernan, Lee M. Shaughnessy, Brendan Thomason, Nathan Fisher, R A McDonald
Publikováno v:
Infection and immunity. 74(7)
Several models of anthrax pathogenesis suggest that early in the infectious process Bacillus anthracis endospores germinate and outgrow into vegetative bacilli within phagocytes before being released into the blood. Here, we define the respective con
Autor:
Lee M. Shaughnessy, Joel A. Swanson
Publikováno v:
Frontiers in Bioscience. 12:2683
Macrophage activation often contributes to the strong immune response elicited upon infection. The ability of macrophages to become activated was discovered when sub-lethal primary infections of mice with the bacterium Listeria monocytogenes provided
Autor:
Shaughnessy, Lee M.1, Hoppe, Adam D.1, Christensen, Kenneth A.2, Swanson, Joel A.1 jswan@umich.edu
Publikováno v:
Cellular Microbiology. May2006, Vol. 8 Issue 5, p781-792. 12p. 1 Black and White Photograph, 1 Diagram, 1 Chart, 6 Graphs.