Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lee M. Boo"'
Autor:
Hung-Jen Chen, Daniel C. Sévin, Guillermo R. Griffith, Johanna Vappiani, Lee M. Booty, Cindy P.A.A. van Roomen, Johan Kuiper, Jeroen den Dunnen, Wouter J. de Jonge, Rab K. Prinjha, Palwinder K. Mander, Paola Grandi, Beata S. Wyspianska, Menno P.J. de Winther
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114741- (2024)
Summary: Macrophages exhibit diverse phenotypes and respond flexibly to environmental cues through metabolic remodeling. In this study, we present a comprehensive multi-omics dataset integrating intra- and extracellular metabolomes with transcriptomi
Externí odkaz:
https://doaj.org/article/ae89bd3f7a5c4e6f9f0d1640e1046c34
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight. In its purest form, GSDMD provides a con
Externí odkaz:
https://doaj.org/article/52dd730f04d149e29d081b2c0416c896
Autor:
Jing Song, Lee M. Boo, Yun Yen, Xiyong Liu, Lijun Zhu, Bingsen Zhou, Ha Van Nguyen, Yuan Chen, David K. Ann, Vincent Chung
Publikováno v:
Molecular Cancer Therapeutics. 5:533-540
Bortezomib, a novel dipeptide boronic acid proteasome inhibitor, has been shown in previous studies to be synergistic with gemcitabine; however, the molecular mechanisms are not fully understood. Because post-translational modification of proteins, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef0052ecd82c216df1a5d991c35217a
https://doi.org/10.1158/1535-7163.mct-05-0290
https://doi.org/10.1158/1535-7163.mct-05-0290
Autor:
Martha Triantafilou, Joshi Ramanjulu, Lee M. Booty, Gisela Jimenez-Duran, Hakan Keles, Ken Saunders, Neysa Nevins, Emma Koppe, Louise K. Modis, G. Scott Pesiridis, John Bertin, Kathy Triantafilou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive th
Externí odkaz:
https://doaj.org/article/59654decd629466e86c28da34c89bb64
Autor:
Oliver Wright, Anna Harris, Van Dien Nguyen, You Zhou, Maxim Durand, Abbie Jayyaratnam, Darren Gormley, Luke A. J. O’Neill, Kathy Triantafilou, Eva Maria Nichols, Lee M. Booty
Publikováno v:
Cells, Vol 12, Iss 23, p 2707 (2023)
The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. However, the specific do
Externí odkaz:
https://doaj.org/article/aea08597c712489e973143c9958d8a70
Autor:
Gisela Jimenez-Duran, Joseph Kozole, Rachel Peltier-Heap, Eleanor R. Dickinson, Christopher R. Kwiatkowski, Francesca Zappacosta, Roland S. Annan, Nicholas W. Galwey, Eva-Maria Nichols, Louise K. Modis, Martha Triantafilou, Kathy Triantafilou, Lee M. Booty
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the innate immune response, as well as contributing
Externí odkaz:
https://doaj.org/article/18224861a8b0475c8ebbec8ed8c12015
Autor:
Lee M. Boo, Teresa Hong, Alan J. Waring, Robert I. Lehrer, Grace L. Su, Ming Hui Fan, Lars Steinstraesser, Stewart C. Wang, Brian F. Tack, Daniel I. Remick
Publikováno v:
Antimicrobial agents and chemotherapy. 46(6)
The emergence of multidrug-resistant microbes has serious implications for managing infection and sepsis and has stimulated efforts to develop alternative treatments, such as antimicrobial peptides. The objective of this study was to test a designer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e1494c91c475132296f38bcf4d455b
https://pubmed.ncbi.nlm.nih.gov/12019098
https://pubmed.ncbi.nlm.nih.gov/12019098