Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Lee M, Ellis"'
Autor:
Susmita Ghosh, Fan Fan, Reid Powell, Yong Sung Park, Clifford Stephan, E. Scott Kopetz, Lee M. Ellis, Rajat Bhattacharya
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: KRAS is frequently mutated in the tumors of patients with metastatic colorectal cancer (mCRC) and thus represents a valid target for therapy. However, the strategies of targeting KRAS directly and targeting the downstream effector mitogen
Externí odkaz:
https://doaj.org/article/ee45b214f3ef4940836a2daafd11ada8
Autor:
Fan Fan, Susmita Ghosh, Reid Powell, Jason Roszik, Yongsun Park, Mary Sobieski, Alexey Sorokin, Clifford Stephan, Scott Kopetz, Lee M Ellis, Rajat Bhattacharya
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0281063 (2023)
Metastatic colorectal cancer (mCRC) is the second leading cause of cancer deaths in the United States. More than 50% of patients with mCRC harbor mutations of the oncogenic driver RAS (KRAS or NRAS). Because directly targeting most mutations of RAS i
Externí odkaz:
https://doaj.org/article/88580e3310194ce49b17f09fa3830037
Autor:
Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, John P.A. Ioannidis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 11-14 (2021)
Externí odkaz:
https://doaj.org/article/c3fa45c6e32349f68ffd7fcab701dc16
Autor:
Lee M. Ellis, Xiongbin Lu, Jing Wang, George A. Calin, Xiaofeng Zheng, Cristina Ivan, Ling Xia, Rui Wang, Delphine R. Boulbes, Seth Bellister, Rajat Bhattacharya, Fan Fan, Xiangcang Ye
Supplementary Figure Legend. Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67de21538f835e8e8297f6e20d6bdce3
https://doi.org/10.1158/1541-7786.22511929.v1
https://doi.org/10.1158/1541-7786.22511929.v1
Autor:
Zhang Weihua, Lee M. Ellis, Seth Bellister, Fan Fan, Jia Lu, Ling Xia, Elizabeth Dupre, Guang Gao, Rajat Bhattacharya, Xiangcang Ye, Federico Tozzi, Lakshmi Reddy Bollu, Yunfei Zhou
PDF file - 840K, Suppl. Figure 1. Conversion of CPT-11 (irinotican) to SN-38 by carboxylesterase; Suppl. Figure 2. Western blot analysis of the basal expression status of ACLy in a panel of colon cancer cell (CRC) lines; Suppl. Figure 3. Overexpressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c443dbce42076dba316e2c0b8ed925c
https://doi.org/10.1158/1535-7163.22498119
https://doi.org/10.1158/1535-7163.22498119
Autor:
Lee M. Ellis, Xiongbin Lu, Jing Wang, George A. Calin, Xiaofeng Zheng, Cristina Ivan, Ling Xia, Rui Wang, Delphine R. Boulbes, Seth Bellister, Rajat Bhattacharya, Fan Fan, Xiangcang Ye
A large number of pseudogenes have been found to be transcribed in human cancers. However, only a few pseudogenes are functionally characterized. Here, we identified a transcribed pseudogene of VEGFR1, or fms-related tyrosine kinase 1 (FLT1), in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8694c9b0ec55f948f0144ee7b9e9a319
https://doi.org/10.1158/1541-7786.c.6540076.v1
https://doi.org/10.1158/1541-7786.c.6540076.v1
Autor:
Lee M. Ellis, Dipen Maru, Veera Baladandayuthapani, Wei Qiao, Susan Venable, Joseph F. Petrosino, Daniel P. Smith, Matthew C. Wong, Nadim J. Ajami, Harish Adoni, Ling Xia, Fan Fan, Delphine R. Boulbes, Rajat Bhattacharya, Rui Wang, Xiangcang Ye
Migration of HCP1 CRC cells in a Boyden chamber system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385a4c1cc7eb8346a0d0dcddf86f6659
https://doi.org/10.1158/1940-6207.22532548
https://doi.org/10.1158/1940-6207.22532548
Autor:
Anil K. Sood, Lee M. Ellis, Gabriel Lopez-Berestein, Scott Kopetz, Heather J. Dalton, Behrouz Zand, Vianey Gonzalez-Villasana, Trent A. Waugh, Kshipra M. Gharpure, Maria Pia Morelli, Archana S. Nagaraja, Cristian Rodriguez-Aguayo, Salma Azam, Anshumaan Maharaj, Rajat Bhattacharya, Takeshi Hisamatsu, Rajesha Rupaimoole, Justyna Filant, Seth Bellister, Sherry Y. Wu, Chad V. Pecot
Despite being among the most common oncogenes in human cancer, to date, there are no effective clinical options for inhibiting KRAS activity. We investigated whether systemically delivered KRAS siRNAs have therapeutic potential in KRAS-mutated cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45069e66acfdb62f9a68c3ddef56c59
https://doi.org/10.1158/1535-7163.c.6536494
https://doi.org/10.1158/1535-7163.c.6536494
Autor:
Anil K. Sood, Lee M. Ellis, Gabriel Lopez-Berestein, Scott Kopetz, Heather J. Dalton, Behrouz Zand, Vianey Gonzalez-Villasana, Trent A. Waugh, Kshipra M. Gharpure, Maria Pia Morelli, Archana S. Nagaraja, Cristian Rodriguez-Aguayo, Salma Azam, Anshumaan Maharaj, Rajat Bhattacharya, Takeshi Hisamatsu, Rajesha Rupaimoole, Justyna Filant, Seth Bellister, Sherry Y. Wu, Chad V. Pecot
Supplementary figure 1 provides a schematic of DOPC:siRNA nanoliposomal preparation, and Supplementary figure 2 shows tumor volumetric measurements of the A549 orthotopic lung cancer therapeutic experiment described in the main figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d907673a1dc060bb20e19e28da20da
https://doi.org/10.1158/1535-7163.22500544
https://doi.org/10.1158/1535-7163.22500544
Autor:
Lee M. Ellis, Dipen Maru, Veera Baladandayuthapani, Wei Qiao, Susan Venable, Joseph F. Petrosino, Daniel P. Smith, Matthew C. Wong, Nadim J. Ajami, Harish Adoni, Ling Xia, Fan Fan, Delphine R. Boulbes, Rajat Bhattacharya, Rui Wang, Xiangcang Ye
Supplementary Figure Legends describe the identification of Fusobacterium by an alternative method and confirmation of CCL20 protein expression by ELISA and functional assays in additional cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380ec3e73a86971db18d923150620777
https://doi.org/10.1158/1940-6207.22532566.v1
https://doi.org/10.1158/1940-6207.22532566.v1