Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lee Langer"'
Autor:
Joshua Drews, Lee Langer, Ezgi Karaesman, Matthew MacKay, Andrew Sedgewick, Joshua Bell, Justin Guinney, Catherine Igartua
Publikováno v:
Cancer Research. 83:3148-3148
Introduction: Cancer tumorigenesis and progression are driven by genetic and epigenetic alterations, giving rise to transcriptional and pathway dysregulation. An approach considering the level of pathway disruption and underlying genomic drivers may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15b4da03e32c20df03974e92d37ca8e
https://doi.org/10.1158/1538-7445.am2023-3148
https://doi.org/10.1158/1538-7445.am2023-3148
Autor:
Matthew Mackay, Nicholas Mitsiades, Young Kwang Chae, Andrew A. Davis, Philip Edward Lammers, James F. Maher, Dan Theodorescu, Peter Rubin, Timothy J. Pluard, Lee Langer, Kabir Manghnani, Rotem Ben-Shachar, Kimberly L. Blackwell, James Lin Chen, Joel Dudley, Justin Guinney, Wade Thomas Iams
Publikováno v:
Journal of Clinical Oncology. 40:3017-3017
3017 Background: Next generation sequencing (NGS) of tumor tissue and plasma (circulating tumor DNA [ctDNA]) are used clinically to identify actionable genomic alterations, with implications for treatment selection and disease surveillance. Early stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c97d3514bb6e225c124a7c67e0de0e
https://doi.org/10.1200/jco.2022.40.16_suppl.3017
https://doi.org/10.1200/jco.2022.40.16_suppl.3017
Publikováno v:
Expert Opinion on Biological Therapy. 7:1245-1256
Breaking immune tolerance against tumor self-antigens is presently an area of intense research in the design of cancer therapies. One possible method to enhance immune system activation against tumor antigens is by blocking the inhibitory co-stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe958c60dcac3ddde642615b326860c
https://doi.org/10.1517/14712598.7.8.1245
https://doi.org/10.1517/14712598.7.8.1245
MicroRNAs and chromatin remodeling complexes represent powerful epigenetic mechanisms that regulate the pluripotent state. miR-302 is a strong inducer of pluripotency, which is characterized by a distinct chromatin architecture. This suggests that mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e2384758a8066432fd73433b94da57
https://europepmc.org/articles/PMC4589888/
https://europepmc.org/articles/PMC4589888/
Publikováno v:
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 51(1)
Objective While SEX-determining region Y-Box 2 ( SOX2) mutations are typically recognized as yielding ocular and central nervous system abnormalities, they have also been associated with other craniofacial defects. To elucidate the genesis of the lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38deb06779966dea8fa36177287320f
https://pubmed.ncbi.nlm.nih.gov/23638914
https://pubmed.ncbi.nlm.nih.gov/23638914
Publikováno v:
Development (Cambridge, England). 140(7)
Within discrete regions of the developing mammalian central nervous system, small subsets of glia become specialized to function as neural stem cells. As a result of their self-renewal and neurogenic capacity, these cells later serve to replenish neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1dbf889e778b12be4ef3ebeca3c139a
https://pubmed.ncbi.nlm.nih.gov/23462474
https://pubmed.ncbi.nlm.nih.gov/23462474
Publikováno v:
Mechanisms of development. 129(1-4)
Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cd7423ec8544e39479f9b55c4d4d23
https://pubmed.ncbi.nlm.nih.gov/22522080
https://pubmed.ncbi.nlm.nih.gov/22522080
Autor:
Timothy M. Clay, Alexander Starodub, H. Kim Lyerly, Michael A. Morse, Lee Langer, Amy Hobeika
Publikováno v:
Surgical oncology clinics of North America. 16(4)
Because chemotherapy is standard in the treatment of colorectal cancer, it is important to demonstrate whether immunizations may be given to patients receiving systemic chemotherapy. Although some studies have demonstrated immune responses in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d24836f412e30ef400b573b39c0ce3d
https://pubmed.ncbi.nlm.nih.gov/18022550
https://pubmed.ncbi.nlm.nih.gov/18022550
Publikováno v:
The Journal of chemical physics. 124(24)
The molecular beam electric resonance technique has been used to conduct a high precision examination of the hyperfine spectrum of the four isotopomers of RbCl. Coupling constants for the nuclear electric quadrupole interactions, the spin-rotation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1c1cfc88edd525b336b28e156b42e3
https://pubmed.ncbi.nlm.nih.gov/16821975
https://pubmed.ncbi.nlm.nih.gov/16821975