Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Lee L, Marshall"'
1
Akademický článek
Trans-omic profiling uncovers molecular controls of early human cerebral organoid formation
Autor: Carissa Chen, Scott Lee, Katherine G. Zyner, Milan Fernando, Victoria Nemeruck, Emilie Wong, Lee L. Marshall, Jesse R. Wark, Nader Aryamanesh, Patrick P.L. Tam, Mark E. Graham, Anai Gonzalez-Cordero, Pengyi Yang
Publikováno v: Cell Reports, Vol 43, Iss 5, Pp 114219- (2024)
Summary: Defining the molecular networks orchestrating human brain formation is crucial for understanding neurodevelopment and neurological disorders. Challenges in acquiring early brain tissue have incentivized the use of three-dimensional human plu
Externí odkaz: https://doaj.org/article/8a7fd637d50344138b8dbe6664cdb3e7
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2
Akademický článek
Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
Autor: Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, Viviane Labrie
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’
Externí odkaz: https://doaj.org/article/f9f6d09087434442861f49df6420270e
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4
In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain
Autor: Bryan A. Killinger, Lee L. Marshall, Diptaman Chatterjee, Yaping Chu, Jose Bras, Rita Guerreiro, Jeffrey H. Kordower
Publikováno v: Proceedings of the National Academy of Sciences. 119
The intracellular misfolding and accumulation of alpha-synuclein into structures collectively called Lewy pathology (LP) is a central phenomenon for the pathogenesis of synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b033becdaa713e7c1f1ebae097584a
https://doi.org/10.1073/pnas.2114405119
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5
Epigenomic analysis of Parkinson's disease neurons identifies Tet2 loss as neuroprotective
Autor: Lee L, Marshall, Bryan A, Killinger, Elizabeth, Ensink, Peipei, Li, Katie X, Li, Wei, Cui, Noah, Lubben, Matthew, Weiland, Xinhe, Wang, Juozas, Gordevicius, Gerhard A, Coetzee, Jiyan, Ma, Stefan, Jovinge, Viviane, Labrie
Publikováno v: Nature neuroscience. 23(10)
Parkinson's disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal functions. Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of patients with PD and of control individual
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18422353ad46f27bd4805557f4fdc67c
https://pubmed.ncbi.nlm.nih.gov/33245171
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6
Increased lipid droplet accumulation associated with a peripheral sensory neuropathy
Autor: Lee L. Marshall, Ryan A. Hyland, Scott E. Stimpson, Simon J. Myers, Jens R. Coorssen
Publikováno v: Journal of Chemical Biology. 7:67-76
Hereditary sensory neuropathy type 1 (HSN-1) is an autosomal dominant neurodegenerative disease caused by missense mutations in the SPTLC1 gene. The SPTLC1 protein is part of the SPT enzyme which is a ubiquitously expressed, critical and thus highly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45b3c13a328c35dd1fb173833876596
https://doi.org/10.1007/s12154-014-0108-y
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7
Author Correction: Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.
Autor: Guennewig B; Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia., Lim J; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Marshall L; St. Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, 2052, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., McCorkindale AN; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Paasila PJ; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Patrick E; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, 2006, Australia., Kril JJ; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Halliday GM; Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia., Cooper AA; St. Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, 2052, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., Sutherland GT; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia. g.sutherland@sydney.edu.au.
Publikováno v: Scientific reports [Sci Rep] 2023 Jun 20; Vol. 13 (1), pp. 9998. Date of Electronic Publication: 2023 Jun 20.
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8
Author Correction: Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.
Autor: Guennewig B; Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia., Lim J; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Rm 6211 Level 6W, Sydney, NSW, 2006, Australia., Marshall L; St. Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, 2052, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., McCorkindale AN; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Rm 6211 Level 6W, Sydney, NSW, 2006, Australia., Paasila PJ; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Rm 6211 Level 6W, Sydney, NSW, 2006, Australia., Patrick E; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, 2006, Australia., Kril JJ; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Rm 6211 Level 6W, Sydney, NSW, 2006, Australia., Halliday GM; Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia., Cooper AA; St. Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, 2052, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., Sutherland GT; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Rm 6211 Level 6W, Sydney, NSW, 2006, Australia. g.sutherland@sydney.edu.au.
Publikováno v: Scientific reports [Sci Rep] 2021 Aug 26; Vol. 11 (1), pp. 17494. Date of Electronic Publication: 2021 Aug 26.
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9
Akademický článek
Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.
Autor: Guennewig B; Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia., Lim J; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Marshall L; St. Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, 2052, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., McCorkindale AN; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Paasila PJ; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Patrick E; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, 2006, Australia., Kril JJ; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia., Halliday GM; Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia., Cooper AA; St. Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, 2052, Australia.; Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia., Sutherland GT; Discipline of Pathology and Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, Rm 6211 Level 6W, The University of Sydney, Sydney, NSW, 2006, Australia. g.sutherland@sydney.edu.au.
Publikováno v: Scientific reports [Sci Rep] 2021 Mar 01; Vol. 11 (1), pp. 4865. Date of Electronic Publication: 2021 Mar 01.
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10
Akademický článek
Hemispheric asymmetry in the human brain and in Parkinson's disease is linked to divergent epigenetic patterns in neurons.
Autor: Li P; Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, 49503, USA., Ensink E; Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, 49503, USA., Lang S; Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, 49503, USA., Marshall L; Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, 49503, USA., Schilthuis M; Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, 49503, USA., Lamp J; Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.; Integrated Mass Spectrometry Unit, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA., Vega I; Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.; Integrated Mass Spectrometry Unit, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA., Labrie V; Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, 49503, USA. viviane.labrie@vai.org.; Division of Psychiatry and Behavioral Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA. viviane.labrie@vai.org.
Publikováno v: Genome biology [Genome Biol] 2020 Mar 09; Vol. 21 (1), pp. 61. Date of Electronic Publication: 2020 Mar 09.
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