Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Lee L, Eckhardt"'
Autor:
Corey L. Anderson, Emma R. Langer, Timothy C. Routes, Seamus F. McWilliams, Igor Bereslavskyy, Timothy J. Kamp, Lee L. Eckhardt
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Hundreds of LMNA variants have been associated with several distinct disease phenotypes. However, genotype–phenotype relationships remain largely undefined and the impact for most variants remains unknown. We performed a functional analysi
Externí odkaz:
https://doaj.org/article/cb36d873da8841c288bf1a7f3c726247
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Disease modeling using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has both challenges and promise. While patient-derived iPSC-CMs provide a unique opportunity for disease modeling with isogenic cells, the challenge is that
Externí odkaz:
https://doaj.org/article/9d886bda78ea473a802fa1842052c92b
Autor:
Corey L. Anderson, Saba Munawar, Louise Reilly, Timothy J. Kamp, Craig T. January, Brian P. Delisle, Lee L. Eckhardt
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Over the last two decades, an exponentially expanding number of genetic variants have been identified associated with inherited cardiac conditions. These tremendous gains also present challenges in deciphering the clinical relevance of unclassified v
Externí odkaz:
https://doaj.org/article/ae94dfc1a53e416cbf25d2dfb342f9e2
Autor:
Lee L. Eckhardt
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/4cee683f04ca4e45a561a70a96b3eeb0
Autor:
Jens Cosedis Nielsen, Yenn‐Jiang Lin, Marcio Jansen de Oliveira Figueiredo, Alireza Sepehri Shamloo, Alberto Alfie, Serge Boveda, Nikolaos Dagres, Dario Di Toro, Lee L. Eckhardt, Kenneth Ellenbogen, Carina Hardy, Takanori Ikeda, Aparna Jaswal, Elizabeth Kaufman, Andrew Krahn, Kengo Kusano, Valentina Kutyifa, Han S. Lim, Gregory Y. H. Lip, Santiago Nava‐Townsend, Hui‐Nam Pak, Gerardo Rodríguez Diez, William Sauer, Anil Saxena, Jesper Hastrup Svendsen, Diego Vanegas, Marmar Vaseghi, Arthur Wilde, T. Jared Bunch
Publikováno v:
Journal of Arrhythmia, Vol 36, Iss 4, Pp 553-607 (2020)
Externí odkaz:
https://doaj.org/article/6cd098381cb64e73a13bd385d12a88f1
Autor:
Yogananda S. Markandeya, Zachery R. Gregorich, Li Feng, Vignesh Ramchandran, Thomas O' Hara, Ravi Vaidyanathan, Catherine Mansfield, Alexis M. Keefe, Carl J. Beglinger, Jabe M. Best, Matthew M. Kalscheur, Martin R. Lea, Timothy A. Hacker, Julia Gorelik, Natalia A. Trayanova, Lee L. Eckhardt, Jonathan C. Makielski, Ravi C. Balijepalli, Timothy J. Kamp
Publikováno v:
Journal of Molecular and Cellular Cardiology. 177:38-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb152118a1a2203da32cab991cb2de6
https://doi.org/10.1016/j.yjmcc.2023.02.005
https://doi.org/10.1016/j.yjmcc.2023.02.005
Autor:
Hanora A. Van Ert, BSN, Elise C. McCune, Kate M. Orland, MS, Kathleen R. Maginot, MD, Nicholas H. Von Bergen, MD, Craig T. January, MD, PhD, Lee L. Eckhardt, MD, FHRS
Publikováno v:
HeartRhythm Case Reports, Vol 3, Iss 2, Pp 151-154 (2017)
Externí odkaz:
https://doaj.org/article/b47d1738642b41beb28395a0234d54f1
Autor:
Wei Zhou, Dan Ye, David J. Tester, Sahej Bains, John R. Giudicessi, Carla M. Haglund-Turnquist, Kate M. Orland, Craig T. January, Lee L. Eckhardt, Kathleen R. Maginot, Michael J. Ackerman
Publikováno v:
Circulation: Genomic and Precision Medicine. 16
Background: Long-QT syndrome (LQTS) is characterized by QT prolongation and increased risk for syncope, seizures, and sudden cardiac death. The majority of LQTS stems from pathogenic mutations in KCNQ1 , KCNH2 , or SCN5A . However, ≈10% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd86c34800629c9ae16de738cae4d3a8
https://doi.org/10.1161/circgen.122.003726
https://doi.org/10.1161/circgen.122.003726
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
In human cardiac ventricular myocytes, caveolin-3 functions as a scaffolding and regulatory protein for signaling molecules and compartmentalizes ion channels. Our lab has recently explored this sub-cellular microdomain and found that potassium inwar
Externí odkaz:
https://doaj.org/article/07fe682f95c44bb99de9a223011ed0d3
Autor:
Michael E. Field, Paolo Donateo, Nicola Bottoni, Matteo Iori, Michele Brignole, Ryan T. Kipp, Douglas E. Kopp, Miguel A. Leal, Lee L. Eckhardt, Jennifer M. Wright, Kathleen E. Walsh, Richard L. Page, Mohamed H. Hamdan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 9 (2018)
BackgroundThe mechanism of inappropriate sinus tachycardia (IST) remains incompletely understood. Methods and ResultsWe prospectively compared 3 patient groups: 11 patients with IST (IST Group), 9 control patients administered isoproterenol (Isuprel
Externí odkaz:
https://doaj.org/article/e797c1a077be491aba3673c13fa00fd7