Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Lee Kraus"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Signal-induced transcriptional programs regulate critical biological processes through the precise spatiotemporal activation of Immediate Early Genes (IEGs); however, the mechanisms of transcription induction remain poorly understood. By com
Externí odkaz:
https://doaj.org/article/22e84590686e4d8195411cc57f4fc209
Autor:
Deitcher David L, Mayberry John, Fogarty Elizabeth A, Fergus Daniel J, Arterbery Adam S, Lee Kraus W, Bass Andrew H
Publikováno v:
BMC Evolutionary Biology, Vol 11, Iss 1, p 14 (2011)
Abstract Background Corticosteroid receptors include mineralocorticoid (MR) and glucocorticoid (GR) receptors. Teleost fishes have a single MR and duplicate GRs that show variable sensitivities to mineralocorticoids and glucocorticoids. How these rec
Externí odkaz:
https://doaj.org/article/072051d02648426e8152a0a2edad01fa
Publikováno v:
Gynecologic Oncology Reports, Vol 48, Iss , Pp S13- (2023)
Objectives: PARP proteins are regulators of DNA damage repair in the cell. PARP inhibitors (PARPi) are a class of drugs used to treat ovarian cancer especially in patients with BRCA 1/2 gene mutations and homologous recombination deficiencies. These
Externí odkaz:
https://doaj.org/article/af268d809c5041b996de63df4a0036a0
Autor:
Sridevi Challa, Keun W Ryu, Amy L Whitaker, Jonathan C Abshier, Cristel V Camacho, W Lee Kraus
Publikováno v:
eLife, Vol 11 (2022)
ADP-ribosylation (ADPRylation) is a reversible post-translation modification resulting in the covalent attachment of ADP-ribose (ADPR) moieties on substrate proteins. Naturally occurring protein motifs and domains, including WWEs, PBZs, and macrodoma
Externí odkaz:
https://doaj.org/article/effbf367334d444b8ea456af01b78316
Autor:
Lavanya H Palavalli Parsons, Sridevi Challa, Bryan A Gibson, Tulip Nandu, MiKayla S Stokes, Dan Huang, Jayanthi S Lea, W Lee Kraus
Publikováno v:
eLife, Vol 10 (2021)
PARP-7 (TiPARP) is a mono(ADP-ribosyl) transferase whose protein substrates and biological activities are poorly understood. We observed that PARP7 mRNA levels are lower in ovarian cancer patient samples compared to non-cancerous tissue, but PARP-7 p
Externí odkaz:
https://doaj.org/article/a58e7e7a531844d7baa4e600daedecdb
Autor:
Dae-Seok Kim, Cristel V. Camacho, Rohit Setlem, Kangsan Kim, Srinivas Malladi, Tim Y. Hou, Tulip Nandu, Shrikanth S. Gadad, W. Lee Kraus
Publikováno v:
Mol Cancer Res
Long noncoding RNAs have been implicated in many of the hallmarks of cancer. Herein, we found that the expression of lncRNA152 (lnc152; a.k.a. DRAIC), which we annotated previously, is highly upregulated in luminal breast cancer (LBC) and downregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa210b816e2e14f013210a18ae1f8725
https://doi.org/10.1158/1541-7786.mcr-22-0123
https://doi.org/10.1158/1541-7786.mcr-22-0123
The bromodomain family member proteins (BRD; BET proteins) are key coregulators for estrogen receptor alpha (ERα)-mediated transcriptional enhancers. The use of BRD-selective inhibitors has gained much attention as a potential treatment for various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aff07d9f58931fc8c0d16d0e271bba8f
https://doi.org/10.1158/1541-7786.c.6540282.v1
https://doi.org/10.1158/1541-7786.c.6540282.v1
Figure S1. The activity of BET family members is required for the growth of T-47D cells. Figure S2. BET proteins are required for E2-dependent gene expression in T-47D cells. Figure S3. JQ1 does not affect the expression of ERα, SRC2, and SRC3 in MC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b247eb964569f4aabe8100ddd7bb617e
https://doi.org/10.1158/1541-7786.22512585.v1
https://doi.org/10.1158/1541-7786.22512585.v1
Autor:
W. Lee Kraus, Shrikanth S. Gadad, Tulip Nandu, Tim Y. Hou, Srinivas Malladi, Kangsan Kim, Rohit Setlem, Cristel V. Camacho, Dae-Seok Kim
Supplementary Table from Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50db936c1d2162c2a9e088d59f9f0204
https://doi.org/10.1158/1541-7786.22527989
https://doi.org/10.1158/1541-7786.22527989
Autor:
W. Lee Kraus, Shrikanth S. Gadad, Tulip Nandu, Tim Y. Hou, Srinivas Malladi, Kangsan Kim, Rohit Setlem, Cristel V. Camacho, Dae-Seok Kim
Supplementary Figure from Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669e6d51c7e60e1a90dc7b5be93bfff1
https://doi.org/10.1158/1541-7786.22527998.v1
https://doi.org/10.1158/1541-7786.22527998.v1