Absence of adverse effects following the gavage administration of methyl propyl trisulfide to Sprague-Dawley rats for 90 days

Autor: Thierry Cachet, Maodo Malick Diop, Lee Koetzner, Gerhard Krammer, Odete Mendes, Michel Aubanel, Xiaodong Li, Maria Bastaki, B. Smith, Craig Llewellyn, Kevin J. Renskers, Jan Demyttenaere, Sean V. Taylor, Shim-mo Hayashi, Christie L. Harman, Jürgen Schnabel

Publikováno v: Food and Chemical Toxicology. 120:544-551

Methyl propyl trisulfide is a flavoring substance found in foods such as garlic and onions. At the request of the European Food Safety Authority (EFSA) for additional toxicological data on methyl propyl trisulfide, groups of Sprague-Dawley rats (10/s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710534974c42d68605519cec2c3c2078
https://doi.org/10.1016/j.fct.2018.07.056

A 14-day repeat dose oral gavage range-finding study of a first-in-class CDI investigational antibiotic, in rats

Autor: Jayson X. Chen, Katherine Sibley, Janice A. Lansita, Odete Mendes, Lee Koetzner, Amy Kimzey, Ramiz A. Boulos

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)

Drug resistant bacteria are winning the fight over antibiotics with some bacteria not responding to any antibiotics, threatening modern medicine as we know it. The development of new, effective and safe antibiotics is critical for addressing this iss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715f7ecf7236c01fe37dadfc93485756
http://europepmc.org/articles/PMC6336794

List of Contributors

Autor: Saleh Adi, Debasis Bagchi, Manashi Bagchi, Pradipta Banerjee, Gillian M. Barlow, Dawn Blatt, Meghan Brashear, Angela I. Calderon, Francesco P. Cappuccio, Sonia Caprio, Esperanza J. Carcache de Blanco, Scott Chaffee, Jayson Chen, Mahua Choudhury, Amitava Das, Stabak Das, Deep Dutta, Charles J. Everett, Christopher Federico, Ivar L. Frithsen, Kei Fukami, Dipyaman Ganguly, Andrea Gerard-Gonzalez, Cosimo Giannini, Kian-Peng Goh, Cheri L. Gostic, Deborah S. Greco, Alok K. Gupta, Daiki Hayashi, Masashi Hosokawa, Md. Akil Hossain, Akifumi Ikehata, William D. Johnson, Lee Koetzner, Michal Krawczyk, Andrew J. Krentz, Abhai Kumar, Teresa E. Lehmann, Eugenia A. Lin, Gail B. Mahady, Sayantan Maitra, Ruchi Mathur, Danira Medunjanin, Odete Mendes, Ajay Menon, Michelle A. Miller, Kazuo Miyashita, Paulin Moszczyński, Beverly S. Mühlhäusler, Satinath Mukhopadhyay, Anand S. Nair, Sreejayan Nair, Shintaro Nakao, Show Nishikawa, Sreedharan N, Min Hi Park, Rokeya Pervin, Harry G. Preuss, Gabriella Pridjian, Mahadev Rao, Sashwati Roy, Ivan Salamon, Nicola Santoro, Suman Santra, Luís F. Schütz, Sonal Sekhar M, Yasuhito Shirai, Smita Singh, Koh-hei Sonoda, James R. Sowers, Anand Swaroop, Zbigniew Tabarowski, Francesco Tecilazich, Yasuhiro Uwadaira, Narsingh Verma, Aristidis Veves, John B. Vincent, Adam Whaley-Connell, Sheila M. Wicks, Marzena Wojcik, Lucyna A. Wozniak, Sho-ichi Yamagishi, Shigeo Yoshida, Mei-Jun Zhu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a473cabb349cadd36786a1821d7f3ff1
https://doi.org/10.1016/b978-0-12-812019-4.01002-3

Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats

Autor: Michael Lyon, Simon Wood, Gary J. Grover, Roland J. Gahler, Joan Wicks, Lee Koetzner, Raylene A. Reimer

Publikováno v: Life Sciences. 88:392-399

Aims The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α- d -glucurono-α- d -manno-β- d -manno-β- d -gluco), (α- l -gulurono-β- d mannurono), β- d -gluco-β- d -mannan (PGX®)] on body weight, food consumption, gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aedabc708e4027619135d825664a57
https://doi.org/10.1016/j.lfs.2010.11.014

Robustness of arterial blood gas analysis for assessment of respiratory safety pharmacology in rats

Autor: Jamie Boulet, Harry Maselli, Bryan Strenkowski, Garth Whiteside, Jessica D. Beyenhof, Michele Hummel, Terri Knappenberger, Janet Dell John, Lee Koetzner

Publikováno v: Journal of pharmacological and toxicological methods. 78

Whole body plethysmography using unrestrained animals is a common technique for assessing the respiratory risk of new drugs in safety pharmacology studies in rats. However, wide variations in experimental technique make cross laboratory comparison of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47138510eb0cd541b263bcbd203a8d37
https://pubmed.ncbi.nlm.nih.gov/26589431