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pro vyhledávání: '"Lee Kaiser"'
Publikováno v:
Drug Information Journal. 46:294-302
Publikováno v:
Clinical Therapeutics. 21:1563-1575
The potential mutual interaction between cerivastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, and digoxin was assessed in this nonmasked, nonrandomized, multiple-dose study. The effect of cerivastatin 0.2 mg on mean plasma digox
Publikováno v:
The International Journal of Neuropsychopharmacology. 1:11-18
Desensitisation of serotonin 1A (5-HT-1A) receptors is a leading hypothesis for the mechanism of action of antidepressants which block serotonin reuptake. This hypothesis predicts that direct-acting 5-HT-1A agonists should also exhibit anti-depressan
Autor:
Florian Bieber, Barry Reisberg, Jon Willmer, Javier I. Escobar, Frank J. Morich, Neal R. Cutler, Lee Kaiser, Jeanne M. Lewis, Ronald C. Petersen
Publikováno v:
Clinical Drug Investigation. 11:185-195
The results of both in vitro and animal studies suggest that calcium dysregulation plays an important role in neuronal cell degeneration, and thus support the use of calcium antagonists for the treatment of Alzheimer’s disease (AD). The aim of this
Publikováno v:
Alzheimer disease and associated disorders. 15(4)
PURPOSE To evaluate the psychometric properties and patterns of decline on the total score and item scores of the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) in patients with Alzheimer Disease (AD). METHODS We analyzed d
Publikováno v:
Statistics in Medicine. 11:1624-1626
Clinical trials data often include baseline and response measurements on each patient. Comparisons of treatments commonly employ either change from baseline or percentage change from baseline as the analysis variable. This paper provides guidance on
Publikováno v:
Journal of clinical pharmacology. 38(8)
The safety, tolerability, and pharmacokinetics of cerivastatin, a novel, synthetic, potent, and highly selective HMG-CoA reductase inhibitor, were studied in 48 young and elderly male volunteers in a randomized, double-blind, placebo-controlled study
Autor:
Lee Kaiser, P. Murali Doraiswamy
Publikováno v:
Neurology. 54:1538-1539
The Mini-Mental State Examination (MMSE) is widely used to screen elderly subjects for cognitive impairment.1 Grigoletto et al.2 highlight the importance of accounting for age, gender, and education while interpreting the MMSE results. The MMSE is al
Autor:
Lee Kaiser
Publikováno v:
Biometrika. 70:505-509
Suppose that Y is an n x 1 observable random vector, normally distributed, with mean XfB and dispersion D(F1, ..., Fk), where X is an n x q matrix of known constants, ,B is a q x 1 vector of unknown parameters, Fj = ((ojtu)), say, is an unknown p x p
Autor:
Lee Kaiser
Publikováno v:
Biometrics. 39:965
SUMMARY A theory for unbiased estimation of the total of arbitrary particle characteristics in line-intercept sampling, for transects of fixed and of random length, is presented. This theory unifies present lineintercept sampling results. Examples ar