Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lee K. Adamson"'
Autor:
Edward E. Tredget, Liju Yang, Kiho Cho, Tam N. Pham, David G. Greenhalgh, Lee K. Adamson, Milad Hakimbashi
Publikováno v:
Cytokine. 27:66-73
Smad signaling mediates the cellular response to transforming growth factor-beta (TGF-beta). We hypothesize that variations in Smad signaling modify the response to TGF-beta signaling in the lung after injury. C57BLKS/J mice were subjected to an 18%
Publikováno v:
Experimental Biology and Medicine. 229:327-334
One of the key events in the regulation of gene expression is chromatin remodeling involving histone regulation. We investigated the effects of burns on the expression of histone that might be associated with altered molecular and pathological profil
Publikováno v:
Journal of Surgical Research. 115:318-324
We recently reported the induction of murine endogenous retroviruses (murine AIDS-related) in several distant organs of mice after burn injury. The regulation of endogenous retroviruses in response to burn injury was further investigated in the thymu
Publikováno v:
Shock. 19:138-143
A key event in the cellular and molecular pathogenesis of multiple organ failure (MOF) after burn injury may be the change in profiles of the cell cycle progression in affected organs. We investigated the effects of burn injury on cell cycle progress
Publikováno v:
Shock. 18:223-229
Burn injury often leads to distant organ injury such as acute respiratory distress syndrome. We hypothesize that the pathophysiologic changes in distant organs result from orchestrated regulation of multiple genes in response to burn injury. Differen
Publikováno v:
Journal of Surgical Research. 104:53-62
To better understand the molecular signaling events leading to systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF), changes in gene expression profiles after burn injury were investigated by differential display. C57BLKS/J
Publikováno v:
Burns. 28:53-56
The current technique determining the extent of capillary leakage after injury is to measure the leakage of dye-labeled foreign albumin. A recent report, however, demonstrated that albumin leakage is dependent upon the type of fluorescent dye used fo
Publikováno v:
Journal of Surgical Research. 98:9-15
Background. Burn injury often causes multiple organ failure as well as skin damage. Several studies suggest that TNF-α plays an important role in postinjury immunosuppression by altering lymphoid tissues. We investigated the regulation of TNF-α exp
Autor:
Kiho, Cho, Lee K, Adamson, Jayoung, Jeong, Sicily D, Crivello, Tajia G, Vanhook, Tina, Palmieri, David G, Greenhalgh
Publikováno v:
The Journal of surgical research. 122(1)
Burn injury-triggered activation of lipopolysaccharide signaling via the CD14 pathway alters the expression of a variety of downstream genes contributing to pathogenic changes in distant organs. The regulation of CD14 and its role in the immediate-ea
Publikováno v:
Experimental and molecular pathology. 75(3)
Chromatin remodeling plays a key role in the transcriptional activation of regulatory factors in the liver in response to a variety of stress signals. The effects of burn injury on histone expression and its modification were investigated in this stu