Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lee K, Marles"'
Autor:
Wiete Westerhof, Bärbel Miehe, Karin U. Schallreuter, Stefanie C. Behrens-Williams, Eva M.J. Peters, Lee K. Marles, Steven M. Picksley, Tahira P. Khaliq, Jochen Fanghänel
Publikováno v:
Experimental Dermatology. 12:268-277
Despite the lack of protective melanin and increased oxidative stress due to mM concentrations of epidermal H2O2 in vitiligo, there is no significantly increased risk for chronic actinic damage and non-melanoma skin cancer. Therefore the question ari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe117fbfc66212848eefdba96abe9ac
https://doi.org/10.1034/j.1600-0625.2003.00084.x
https://doi.org/10.1034/j.1600-0625.2003.00084.x
Publikováno v:
Experimental Dermatology. 12:61-70
Both human epidermal melanocytes and keratinocytes have the full capacity for de novo synthesis of 6(R) L-erythro 5,6,7,8, tetrahydrobiopterin, the essential cofactor for the rate limiting step in catecholamine synthesis, via tyrosine hydroxylase. Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784b55b719f02af3e84c88b0bb7c68dd
https://doi.org/10.1034/j.1600-0625.2003.120108.x
https://doi.org/10.1034/j.1600-0625.2003.120108.x
Autor:
Eva M.J. Peters, Reinhard Dummer, Lee K. Marles, Nenad Blau, Wayne D. Beazley, Stefanie C. Behrens-Williams, Jeremy Moore, John M. Wood, Karin U. Schallreuter, Beat Thöny
Publikováno v:
Journal of Investigative Dermatology. 116(1):167-174
It has been shown in vivo that patients with the depigmentation disorder vitiligo accumulate hydrogen peroxide (H(2)O(2)) accompanied by low catalase levels and high concentrations of 6- and 7-biopterin in their epidermis. Earlier it was demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61936473adeca599e6fbfd3b9eef0631
Autor:
John M. Wood, Karin U. Schallreuter, Derek J. Maitland, Mohammad Shalbaf, Lee K. Marles, Hartmut Rokos, Souna M. Elwary, Nicholas C.J. Gibbons
Publikováno v:
Experimental dermatology. 17(9)
Xanthine dehydrogenase/xanthine oxidase (XDH/XO) catalyses the hydroxylation of hypoxanthine to xanthine and finally to uric acid in purine degradation. These reactions generate H(2)O(2) yielding allantoin from uric acid when reactive oxygen species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fa64a2c8fb80f5449506e9808d5bb5
https://pubmed.ncbi.nlm.nih.gov/18328088
https://pubmed.ncbi.nlm.nih.gov/18328088
Autor:
Karin U. Schallreuter, Hartmut Rokos, Bhaven Chavan, Söbia Kauser, Jennifer D. Spencer, Lee K. Marles
Publikováno v:
The Journal of endocrinology. 187(2)
The human skin holds the full machinery for pro-opiomelanocortin processing. The α-melanocyte-stimulating hormone (α-MSH)/melanocortin-1-receptor cascade has been implicated as a major player via the cAMP signal in the control of melanogenesis. Onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fc385fe290c907fca44cb89cc261ea
https://pubmed.ncbi.nlm.nih.gov/16293777
https://pubmed.ncbi.nlm.nih.gov/16293777
Publikováno v:
The Journal of investigative dermatology. 123(2)
Earlier it has been shown that human proliferating/undifferentiated basal keratinocytes hold the full capacity for autocrine catecholamine synthesis/degradation and express beta2-adrenoceptors (beta2-AR). In this report, we show that human melanocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb6936d9a55525436c36ea269221f434
https://pubmed.ncbi.nlm.nih.gov/15245435
https://pubmed.ncbi.nlm.nih.gov/15245435
Publikováno v:
Experimental dermatology. 12(1)
Both human epidermal melanocytes and keratinocytes have the full capacity for de novo synthesis of 6(R) L-erythro 5,6,7,8, tetrahydrobiopterin, the essential cofactor for the rate limiting step in catecholamine synthesis, via tyrosine hydroxylase. Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64a1bf3c23f89de24b926285bcd6458f
https://pubmed.ncbi.nlm.nih.gov/12631248
https://pubmed.ncbi.nlm.nih.gov/12631248
Publikováno v:
Journal of Investigative Dermatology. (2):346-353
Earlier it has been shown that human proliferating/undifferentiated basal keratinocytes hold the full capacity for autocrine catecholamine synthesis/degradation and express β 2 -adrenoceptors (β 2 -AR). In this report, we show that human melanocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ccfe524f0e8bd533537b2f0aaf7b0b
Publikováno v:
Journal of Investigative Dermatology. (2):307-313
To date there is ample evidence that patients with vitiligo accumulate millimolar concentrations of hydrogen peroxide (H2O2) in their epidermis as well as in their blood lymphocytes/monocytes. Several enzymes are affected by this H2O2 including catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8250fdc98ad843ab69c096118379264b