Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.

Autor: Cheung CCL; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Seah YHJ; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Fang J; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Orpilla NHC; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Temasek Polytechnic, Singapore, Singapore., Lau MC; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim CJ; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim X; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lee JNLW; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim JCT; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim S; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Cheng Q; Duke-NUS Medical School, Singapore, Singapore.; Center of Statistical Research, School of Statistics, Southwestern University of Finance and Economics, Chengdu, Sichuan, China., Toh HC; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Choo SP; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Lee SY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Lee JJX; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Liu J; Duke-NUS Medical School, Singapore, Singapore., Lim TKH; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Tai D; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Yeong J; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.; Singapore Immunology Network (SIgN), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jun 05; Vol. 14, pp. 1150985. Date of Electronic Publication: 2023 Jun 05 (Print Publication: 2023).