Výsledky vyhledávání - "Lee J. McDonald"

Comparative Metabolism and Toxicokinetics of 14C-ResorcinoI Bis-Diphenylphosphate (RDP) in the Rat, Mouse, and Monkey

Autor: Jodie V. Johnson, Richard T. Henrich, David L. McCormick, Ralph I. Freudenthal, Lee J. McDonald

Publikováno v: International Journal of Toxicology. 19:233-242

As part of a comprehensive program to examine the safety and toxicokinetics of the flame retardant, resorcinol bis-diphenylphosphate (RDP), the metabolism and toxicokinetics of RDP was determined after exposure of rats and monkeys to 14C-RDP via intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a89f303bda658757f7bf24a257b9221
https://doi.org/10.1080/10915810050202042

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Autor: Jeffrey S. Barrett, Lee J. McDonald, Esther M. Morris, Anthony R. DiSanto, John Darnow, Shashank Rohatagi

Publikováno v: Pharmaceutical Research. 14:50-55

Purpose. A Selegiline Transdermal System (STS) is under development for indications which may not be optimally or safely treated with oral selegiline. Studies were conducted to evaluate the in vitro penetration and skin metabolism of selegiline in or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7266d92f6e8fa5981143aeeb0b21416a
https://doi.org/10.1023/a:1012051300130

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Nitric Oxide and Cyclic GMP Signaling

Autor: Lee J. McDonald, Ferid Murad

Publikováno v: Experimental Biology and Medicine. 211:1-6

NO and cGMP constitute an autocrine, paracrine, and possible endocrine signal transduction system. Cytosolic NO-responsive guanylyl cyclase can be stimulated by NO derived from its own cell, from similar or distinct neighboring cell types within a ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb36cf1d10ff4129401bc1a4bb2ee7e
https://doi.org/10.3181/00379727-211-43950a

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Stimulation by nitric oxide of an NAD linkage to glyceraldehyde-3-phosphate dehydrogenase

Autor: Joel Moss, Lee J. McDonald

Publikováno v: Proceedings of the National Academy of Sciences. 90:6238-6241

Nitric oxide-stimulated modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by [adenylate-32P]NAD has been interpreted in recent reports as ADP-ribosylation. Incubations of GAPDH with the NO-releasing agent sodium nitroprusside (SNP) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356af6ac1c8dff597c96c3371f3ce279
https://doi.org/10.1073/pnas.90.13.6238

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Nitric Oxide and cGMP Signaling

Autor: Ferid Murad, Lee J. McDonald

Publisher Summary This chapter covers the general topic of nitric oxide (NO) and cGMP-mediated signaling, while focusing on a few recent interesting findings. Research and interest in NO-related signaling and its connection to cGMP are increasing con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54acf3620e7666219aca0c193419ee14
https://doi.org/10.1016/s1054-3589(08)61091-1

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Phosphoinositide hydrolysis by phospholipase C modulated by multivalent cations La(3+), Al(3+), neomycin, polyamines, and melittin

Autor: Mark D. Mararack, Lee J. McDonald

Publikováno v: Journal of lipid mediators and cell signalling. 11(1)

Second messenger production from phosphoinositide hydrolysis is regulated by different pathways, such as G-proteins or tyrosine phosphorylation of phosphoinositide phospholipase C (PI-PLC). Another means of altering the activity of PI-PLC is through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af032a182c04eb70ead7e276639fc8b
https://pubmed.ncbi.nlm.nih.gov/7728419

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Enzymatic and nonenzymatic ADP-ribosylation of cysteine

Autor: Lee J. McDonald, Joel Moss

Publikováno v: Molecular and cellular biochemistry. 138(1-2)

Mono-ADP-ribosylation is a protein modification that occurs at a number of different amino acids, dictated by the specificity of the individual ADP-ribosyltransferases. A specific cysteine in several guanine nucleotide-binding regulatory proteins is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4113843a6b87bf73c7b7c81ed41d0f
https://pubmed.ncbi.nlm.nih.gov/7898467

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Nitric oxide and NAD-dependent protein modification

Autor: Joel Moss, Lee J. McDonald

Publikováno v: Molecular and cellular biochemistry. 138(1-2)

Nitric oxide (NO) has been suggested to act as a regulator of endogenous intracellular ADP-ribosylation, based on radiolabelling of proteins in tissue homogenates incubated with [32P]NAD and NO. After the NO-stimulated modification was replicated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf4621963455b25848f5c1e2aafb91d
https://pubmed.ncbi.nlm.nih.gov/7898464

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