Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lee J. Burns"'
Autor:
Rebecca L. Davis-Harrison, Alastair J. Florence, Jeremy Hinds, Scott Alan Frank, Frederik J.S. Doerr, Lee J. Burns, Becky Lee
Publikováno v:
Pharmaceutical Research
Purpose Spray drying plays an important role in the pharmaceutical industry for product development of sensitive bio-pharmaceutical formulations. Process design, implementation and optimisation require in-depth knowledge of process-product interactio
Autor:
Lysiane Huber, David Anthony Barda, Youyan Zhang, Sheng-Bin Peng, Xueqian Gong, Junpeng Xiao, Deqi Guo, Jing Wang, Carmen Curtis, Bradley L. Ackermann, Wayne P. Bocchinfuso, Danalyn Manglicmot, Gregory P. Donoho, Paul D. Cornwell, Ryan J. Linder, Chong Si, Lee J. Burns, Michael J. Chalmers, Xi Lin, Denis J. McCann, Henry James Robert, Robert D. Van Horn, Serge Louis Boulet, Melbert-Brian D. Saflor, John Strelow, Lian Zhou
Publikováno v:
Cancer Research. 81:1259-1259
KRAS-G12C is an important oncogenic mutation in patients with NSCLC, CRC, and other cancer types. Currently, there are no FDA-approved KRAS-G12C inhibitors, and those in clinical development have relatively modest activity compared to other approved
Autor:
David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard
Publikováno v:
International Journal of Pharmacokinetics. 2:81-91
Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the P
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4756-4765
Dogs are one of the most commonly used non-rodent species in toxicology studies and are known to have basal stomach pH ranging from 2 to 7 in the fasted state. Thus absorption and resulting plasma exposure of weakly basic compounds administered as cr
Publikováno v:
The AAPS journal. 17(6)
Effective integration of in vitro tests and absorption modeling can greatly improve our capability in understanding, comparing, and predicting in vivo performances of clinical drug products. In this case, we used a proprietary drug candidate galunise
Autor:
Shobha N. Bhattachar, Lee J. Burns
Publikováno v:
Proceedings of The 2nd Electronic Conference on Pharmaceutical Sciences.