Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lee Hopkins"'
Autor:
Sarah Louise Latty, Jiro Sakai, Lee Hopkins, Brett Verstak, Teresa Paramo, Nils A Berglund, Eugenia Cammarota, Pietro Cicuta, Nicholas J Gay, Peter J Bond, David Klenerman, Clare E Bryant
Publikováno v:
eLife, Vol 7 (2018)
Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is thought to drive digital all-or-none responses, yet TL
Externí odkaz:
https://doaj.org/article/ec0354b0493a40a8bfcede70576b1981
Autor:
Yorgo Modis, Jonathan D. Howe, Yangci Liu, Haoming Zhai, Clare E. Bryant, Lee Hopkins, Helen Alemayehu, Alicia C. Borgeaud, Jérôme Boulanger, Christina Heroven
NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation. Aberrant activity of NLRP3 occurs in many human diseases. NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum. Higher resolution im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b861aa4c40be6d50903d7a5be66101
https://doi.org/10.1101/2021.09.20.461078
https://doi.org/10.1101/2021.09.20.461078
Autor:
Robert J. Pickering, Lee Hopkins, Panagiotis Tourlomousis, Joseph P. Boyle, James Rooney, Tom P. Monie, Søren Warming, Nobuhiko Kayagaki, Betsaida Bibo-Verdugo, Zsofia Digby, Steve J. Webster, Guy S. Salvesen, Clare E. Bryant, Lucy A. Weinert
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109614-(2021)
Cell Reports
Cell Reports
Summary Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df4b31528ec19572257040cf0ef6a0e
https://www.repository.cam.ac.uk/handle/1810/326412
https://www.repository.cam.ac.uk/handle/1810/326412
Autor:
Wei-Hsin Chen, Yu Ye, Craig D. Hughes, Bing Li, Clare E. Bryant, David Klenerman, Lee Hopkins, Aleks Ponjavic
Detection of single molecules in biological systems has rapidly increased in resolution over the past decade. However, delivery of single molecules has remained a challenge. Currently there is no effective method that can both introduce a precise amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdc68fb2c563cddc885180143c0bb63
Autor:
Zsofia Digby, Robert J. Pickering, Lee Hopkins, Nobuhiko Kayagaki, Joseph P. Boyle, Betsy Bibo Verdugo, Clare E. Bryant, Tom P. Monie, Søren Warming, James Rooney, Guy S. Salvesen, Steve J. Webster, Lucy A. Weinert
Publikováno v:
SSRN Electronic Journal.
Zoonotic infections, such as COVID-19, reside in animal hosts before jumping species to humans. The Carnivora, like mink, carry many zoonoses yet how diversity in host immune genes across species impact upon pathogen carriage are poorly understood. H
Autor:
Steve J. Webster, Lee Hopkins, Alessandra S Bittante, Duncan J. Maskell, John A. Wright, Clare E. Bryant, Panagiotis Tourlomousis, Owain J. Bryant, Pietro Mastroeni
Publikováno v:
Nat Microbiol
Pattern recognition receptors (PRRs) expressed in antigen-presenting cells are thought to shape pathogen-specific immunity by inducing secretion of co-stimulatory cytokines during T-cell activation, yet data to support this notion in vivo is surprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3065850fc7b499f509944d89b2a646
Author response: Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub
Autor:
Brett Verstak, Nils A. Berglund, Teresa Paramo, Jiro Sakai, Sarah L. Latty, Clare E. Bryant, Eugenia Cammarota, Lee Hopkins, Pietro Cicuta, Peter J. Bond, David Klenerman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4bf821e83c3f82434a04a208b7c0c8a
https://doi.org/10.7554/elife.31377.021
https://doi.org/10.7554/elife.31377.021
Autor:
Ivo M. Glück, Pietro Cicuta, Panagiotis Tourlomousis, Lee Hopkins, Clare E. Bryant, Susan Cox, John A. Wright, Tom P. Monie, Si Ming Man, Eileen Nugent
Publikováno v:
Proceedings of the National Academy of Sciences. 111:7403-7408
Pathogen recognition by nucleotide-binding oligomerization domain-like receptor (NLR) results in the formation of a macromolecular protein complex (inflammasome) that drives protective inflammatory responses in the host. It is thought that the number
Autor:
Panagiotis Tourlomousis, Lee Hopkins, Si Ming Man, Clare E. Bryant, Katherine A. Fitzgerald, Tom P. Monie
Publikováno v:
The Journal of Immunology. 191:5239-5246
Nucleotide-binding oligomerization domain–like receptors (NLRs) detect pathogens and danger-associated signals within the cell. Salmonella enterica serovar Typhimurium, an intracellular pathogen, activates caspase-1 required for the processing of t
Autor:
Minee L. Choi, Sarah A. Gagliano, Maria Iljina, Craig D. Hughes, Sonia Gandhi, David Klenerman, Mina Ryten, Anna Drews, Juan A. Botía, Lee Hopkins, Margarida Rodrigues, Clare E. Bryant
Publikováno v:
Acta neuropathologica 137(1), 121-121 (2019). doi:10.1007/s00401-018-1919-7
In the original publication of this article, the author Magarida Rodrigues was written incorrectly.