Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial

Autor: Philip M Bath, Polly Scutt, Craig S Anderson, Jason P Appleton, Evind Berge, Lesley Cala, Mark Dixon, Timothy M England, Peter J Godolphin, Diane Havard, Lee Haywood, Trish Hepburn, Kailash Krishnan, Grant Mair, Alan A Montgomery, Keith Muir, Stephen J Phillips, Stuart Pocock, John Potter, Chris Price, Marc Randall, Thompson G Robinson, Christine Roffe, Peter M Rothwell, Else C Sandset, Nerses Sanossian, Jeffrey L Saver, Angela Shone, A Niroshan Siriwardena, Joanna M Wardlaw, Lisa J Woodhouse, Graham Venables, Nikola Sprigg, Pierre Amarenco, Shannon Amoils, Malcolm Jarvis, Peter Sandercock, Kjell Asplund, Colin Baigent, Sandeep Ankolekar, Harriet Howard, Christopher Lysons, Gemma Walker, Hayley Gregory, James Kirby, Jennifer Smithson, Joanne Keeling, Nadia Frowd, Robert Gray, Richard Dooley, Wim Clarke, Patricia Robinson, Zhe Kang Law, Sheila Hodgson, Adam Millington, Eleni Sakka, David Buchanan, Jeb Palmer, D Shaw, H Cobb, R Johnson, T Payne, R Spaight, A Spaight, M A Sajid, A Whileman, E Hall, H Cripps, J Toms, R Gascoyne, S Wright, M Cooper, A Palfreman, A Rajapakse, I Wynter, K Musarrat, A Mistri, C Patel, C Stephens, S Khan, S Patras, M Soliman, A Elmarimi, C Hewitt, E Watson, I Wahishi, J Hindle, L Perkin, M Wills, S Arif, S Leach, S Butler, D O'Kane, C Smith, J O'Callaghan, W Sunman, A Buck, B Jackson, C Richardson, G Wilkes, J Clarke, L Ryan, O Matias, D Mangion, A Hardwick, C Constantin, I Thomas, K Netherton, S Markova, A Hedstrom, B Rushton, C Hyde, J Scott, M Blair, M Maddula, R Donnelly, S Keane, S Johnson, H McKenzie, A Banerjee, D Hutchinson, H Goodhand, J Hill, K Mellows, M Cheeseman, V McTaggart, T Foster, L Prothero, P Saksena, A O'Kelly, H Wyllie, C Hacon, H Nutt, J North, K Goffin, J Potter, A Wiltshire, G Ravenhill, K Metcalf, L Ford, M Langley, W Davison, S Subramonian, F Magezi, I Obi, N Temple, N Butterworth-Cowin, P Oqwusu-Agyei, A F M Azim, A Nicolson, J Imam, J White, L Wood, R Fothergill, N Thompson, J Lazarus, H Werts, L Sztriha, C Ho, E McKenzie, E Owoyele, J Lim, J Aeron-Thomas, M Dockey, N Sylvester, P Rao, B M Bloom, E Erumere, G Norman, I Skene, L Cuenoud, L Howaniec, O Boulton, P Daboo, R Michael, S Al-Saadi, T Harrison, H Syed, L Argandona, S Amiani, R Perry, A Ashton, A Banaras, C Hogan, C Watchurst, E Elliott, N Francia, N Oji, R Erande, S Obarey, S Feerick, S Tshuma, E England, H Pocock, K Poole, S Manchanda, I Burn, S Dayal, K McNee, M Robinson, R Hancock, A South, C Holmes, A Steele, L B Guthrie, M Oborn, A Mohd Nor, B Hyams, C Eglinton, D Waugh, E Cann, N Wilmhurst, S Piesley, S Shave, D Dutta, M Obeid, D Ward, J Turfrey, J Glass, K Bowstead, L Hill, P Brown, S Beames, S O'Connell, V Hughes, R Whiting, J Gagg, M Hussain, M Harvey, D Karunatilake, B Pusuluri, A Witcher, C Pawley, J Allen, J Foot, J Rowe, C Lane, S Ragab, B Wadams, J Dube, B Jupp, A Ljubez, C Bagnall, G Hann, L Tucker, M Kelton, S Orr, F Harrington, A James, A Lydon, G Courtauld, K Bond, L Lucas, T Nisbett, J Kubie, A Bowring, G Jennings, K Thorpe, N Mason, S Keenan, L Gbadomishi, D Howcroft, H Newton, J Choulerton, J Avis, L Shaw, P Paterson, P Kaye, S Hierons, S Lucas, P Clatworthy, B Faulkner, L Rannigan, R Worner, B Bhaskaran, A Saulat, H Bearne, J Garfield-Smith, K Horan, P Fitzell, S Szabo, M Haley, D Simmons, D Cotterill, G Saunders, H Dymond, S Beech, K Rashed, A Tanate, C Buckley, D Wood, L Matthews, S Board, T Pitt-Kirby, N Rees, C Convery, P Jones, C Bryant, H Tench, M Dixon, R Loosley, S Coetzee, S Jones, T Sims, M Krishnan, C Davies, L Quinn, L Connor, M Wani, S Storton, S Treadwell, T Anjum, C Somashekar, A Chandler, C Triscott, L Bevan, M Sander, S Buckle, W Sayed, K Andrews, L Hughes, R Hughes, M Ward, A Pretty, A Rosser, B Davidson, G Price, I Gunson, J Lumley-Holmes, J Miller, M Larden, M Jhamat, P Horwood, R Boldy, C Jenkins, F Price, M Harrison, T Martin, N Ahmad, A Willberry, A Stevens, K Fotherby, A Barry, A Remegoso, F Alipio, H Maquire, J Hiden, K Finney, R Varquez, S Ispoglou, A Hayes, D Gull, R Evans, E Epstein, S Hurdowar, J Crossley, J Miles, K Hird, R Pilbery, C Patterson, H Ramadan, K Stewart, O Quinn, R Bellfield, S Macquire, W Gaba, A Nair, A Wilson, C Hawksworth, I Alam, J Greig, P Gomes, P Rana, Z Ahmed, P Anderston, A Neal, D Walstow, R Fong, S Brotheridge, A Bwalya, A Gillespie, C Midgley, C Hare, H Lyon, L Stephenson, M Broome, R Worton, S Jackson, R Rayessa, A Abdul-Hamid, C Naylor, E Clarkson, A Hassan, E Veraque, L Finch, L Makawa, M Carpenter, P Datta, A Needle, L Jackson, H J Brooke, J Ball, T Lowry, S Punnoose, R Walker, V Murray, A Ali, C Kamara, C Doyle, E Richards, J Howe, K Dakin, K Harkness, R Lindert, P Wanklyn, P Willcoxson, P Clark-Brown, R Mir

Publikováno v: 2019, ' Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2) : An ambulance-based, randomised, sham-controlled, blinded, phase 3 trial ', The Lancet, vol. 393, no. 10175, pp. 1009-1020 . https://doi.org/10.1016/S0140-6736(19)30194-1

Background: High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure have given variable results, and the management of high blood pressure in ultra-acute stroke remains unclea

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