Výsledky vyhledávání - "Lee H. Latimer"

Autor: Lee H. Latimer

Publikováno v: C&EN Global Enterprise. 99:34-34

The new year is a good opportunity to initiate new efforts in both our public and private lives. The pandemic is still raging, but vaccines are providing a promising vision of the future: 2021 look...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd46e6d82ce06b861e7ab29d6a089fee
https://doi.org/10.1021/cen-09905-comment

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New opportunities amid the challenges of the pandemic

Autor: Lee H. Latimer, Acs director-at-large

Publikováno v: C&EN Global Enterprise

he challenges of the novel coronavirus pandemic are evident all around us But out of these challenges come substantial new opportunities Who knew we could participate in an American Chemical Society national meeting from our home offices, work office

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2448db67c2f550c7d7ddca83670fbb21
https://doi.org/10.1021/cen-09841-comment

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Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain

Publikováno v: ChemMedChem. 8:1295-1313

Polo-like kinase-2 (Plk-2) has been implicated as the dominant kinase involved in the phosphorylation of α-synuclein in Lewy bodies, which are one of the hallmarks of Parkinson's disease neuropathology. Potent, selective, brain-penetrant inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9de472a2de2bc218c1224fe31845aba
https://doi.org/10.1002/cmdc.201300166

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Discovery of (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Autor: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele

Publikováno v: Journal of Medicinal Chemistry. 56:5261-5274

Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201
https://doi.org/10.1021/jm301741t

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Choose your chemistry adventure, and take action

Autor: Lee H. Latimer

Publikováno v: C&EN Global Enterprise. 96:33-33

What led you to join the American Chemical Society and to your first involvement with a local section or technical division? My adventure with ACS began in graduate school when I joined with other students to gain access to its numerous journals to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::935ac1caa1894dfeec18aa4c797fbc65
https://doi.org/10.1021/cen-09606-comment

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch

Autor: Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi

Publikováno v: Journal of medicinal chemistry. 56(13)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::109e2b6e92821a752624dca210f7b056
https://pubmed.ncbi.nlm.nih.gov/23713656

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