Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Lee H. Chen"'
Autor:
Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz, Hideho Okada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider a
Externí odkaz:
https://doaj.org/article/4c9ca26f096d46feb278b4dfc8e66f04
Autor:
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Liwei Zhang, Matthew S. Waitkus, Yiping He, Hai Yan
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-12 (2021)
Abstract Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that DIPGs are resistant to chemotherapy and are not amenable
Externí odkaz:
https://doaj.org/article/e93641f3ec424b8eb9474f91fac10d50
Autor:
Lee H. Chen, Changcun Pan, Bill H. Diplas, Cheng Xu, Landon J. Hansen, Yuliang Wu, Xin Chen, Yibo Geng, Tao Sun, Yu Sun, Peng Zhang, Zhen Wu, Junting Zhang, Deling Li, Yang Zhang, Wenhao Wu, Yu Wang, Guangyu Li, Jie Yang, Xiaoyue Wang, Ce Xu, Sizhen Wang, Matthew S. Waitkus, Yiping He, Roger E. McLendon, David M. Ashley, Hai Yan, Liwei Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical
Externí odkaz:
https://doaj.org/article/20c3ed793a784a5b8bd512a9238d11e8
Autor:
Simranjit X. Singh, Rui Yang, Kristen Roso, Landon J. Hansen, Changzheng Du, Lee H. Chen, Paula K. Greer, Christopher J. Pirozzi, Yiping He
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 751 (2022)
Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, pro
Externí odkaz:
https://doaj.org/article/a2f34eeb4d164ba6a4ede50903e97f18
Autor:
Bill H. Diplas, Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner, Yuchen Jiao, Matthew S. Waitkus, Alan K. Meeker, Hai Yan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying
Externí odkaz:
https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Genes displaying more than 2-fold change among IDH1LSL:R132H/WT ad-GFP versus ad-Cre NSCs were selected for pathway analysis by DAVID.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0474a9e4bef24cd9485631bd44f80b72
https://doi.org/10.1158/1541-7786.22517364
https://doi.org/10.1158/1541-7786.22517364
Autor:
Hai Yan, Yiping He, Matthew S. Waitkus, Ivan Spasojevic, Zhaohui Wang, Christopher J. Pirozzi, Rui Yang, Lee H. Chen, Bill H. Diplas, Casey J. Moure
Differentially Methylated Probes Parental vs. Edited Clones or Parental vs. Unedited Clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267db3d0d1df51bfdc550c6257af44ff
https://doi.org/10.1158/1541-7786.22513459.v1
https://doi.org/10.1158/1541-7786.22513459.v1
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Sequences of primers used for genotyping of animals and for q-RT-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afe34e6d83cdc07de43702046ba43a7
https://doi.org/10.1158/1541-7786.22517370.v1
https://doi.org/10.1158/1541-7786.22517370.v1
Autor:
Hai Yan, Yiping He, Matthew S. Waitkus, Ivan Spasojevic, Zhaohui Wang, Christopher J. Pirozzi, Rui Yang, Lee H. Chen, Bill H. Diplas, Casey J. Moure
Conummee Copy Number Calls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6349ec79b13cd5b5556977db980e8004
https://doi.org/10.1158/1541-7786.22513465
https://doi.org/10.1158/1541-7786.22513465
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Affymetrix GeneChip Mouse Gene 2.0ST Array used for gene expression profiling. Gene list displays those genes with more than 2-fold change when comparing IDH1LSL:R132H/WT ad-GFP transduced NSCs compared to IDH1LSL:R132H/WT ad-Cre transduced NSCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38f5eb15e10646404cc04771b377f71
https://doi.org/10.1158/1541-7786.22517367
https://doi.org/10.1158/1541-7786.22517367