Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Lee Gehrke"'
Autor:
Alfred T. Harding, Karen Ocwieja, Minjin Jeong, Yichen Zhang, Valerie Leger, Nairuti Jhala, Konstantina M. Stankovic, Lee Gehrke
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTCongenital hearing loss is a common chronic condition affecting children in both developed and developing nations. Viruses correlated with congenital hearing loss include human cytomegalovirus (HCMV) and Zika virus (ZIKV), which causes congen
Externí odkaz:
https://doaj.org/article/d952475ee8e2487e8275ecf2a527d2d4
Autor:
Cassia F Estofolete, Alice F Versiani, Fernanda S Dourado, Bruno H G A Milhim, Carolina C Pacca, Gislaine C D Silva, Nathalia Zini, Barbara F Dos Santos, Flora A Gandolfi, Natalia F B Mistrão, Pedro H C Garcia, Rodrigo S Rocha, Lee Gehrke, Irene Bosch, Rafael E Marques, Mauro M Teixeira, Flavio G da Fonseca, Nikos Vasilakis, Maurício L Nogueira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011710 (2023)
BackgroundThe co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study inv
Externí odkaz:
https://doaj.org/article/c32f9c4df8864199829223b9b42c28f5
Autor:
Kimino Fujimura, Amanda J. Guise, Tojo Nakayama, Christoph N. Schlaffner, Anais Meziani, Mukesh Kumar, Long Cheng, Dylan J. Vaughan, Andrew Kodani, Simon Van Haren, Kenneth Parker, Ofer Levy, Ann F. Durbin, Irene Bosch, Lee Gehrke, Hanno Steen, Ganeshwaran H. Mochida, Judith A. Steen
Publikováno v:
iScience, Vol 26, Iss 7, Pp 106909- (2023)
Summary: Characterizing perturbation of molecular pathways in congenital Zika virus (ZIKV) infection is critical for improved therapeutic approaches. Leveraging integrative systems biology, proteomics, and RNA-seq, we analyzed embryonic brain tissues
Externí odkaz:
https://doaj.org/article/51cd38694972434695fcef207fb0e48f
Autor:
Minjin Jeong, Karen E. Ocwieja, Dongjun Han, P. Ashley Wackym, Yichen Zhang, Alyssa Brown, Cynthia Moncada, Andrea Vambutas, Theodore Kanne, Rachel Crain, Noah Siegel, Valerie Leger, Felipe Santos, D. Bradley Welling, Lee Gehrke, Konstantina M. Stankovic
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-14 (2021)
Plain language summary Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the novel coronavirus SARS-CoV-2. A growing number of sensory symptoms have been linked to this illness. Here, we describe patients with COVID-19 and new-on
Externí odkaz:
https://doaj.org/article/caaa18033e444b8284794201f082d3fe
Autor:
Alexsia Richards, Max Friesen, Andrew Khalil, M. Inmaculada Barrasa, Lee Gehrke, Rudolf Jaenisch
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105146- (2022)
Summary: Although respiratory symptoms are the most prevalent disease manifestation of infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), infection can also damage other organs, including the brain, gut, and liver. Symptoms of
Externí odkaz:
https://doaj.org/article/6fe950a3bccd498c9cd42bb4b1a67f54
Autor:
Alexandre Albanese, Justin M. Swaney, Dae Hee Yun, Nicholas B. Evans, Jenna M. Antonucci, Silvia Velasco, Chang Ho Sohn, Paola Arlotta, Lee Gehrke, Kwanghun Chung
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. These three-dimensional models offer an unprecedented opportunity to study human brain development and dysfun
Externí odkaz:
https://doaj.org/article/fb1882f90ac742849d2c12265a68b902
Autor:
Irene Bosch, Ankita Reddy, Helena de Puig, Juan E Ludert, Federico Perdomo-Celis, Carlos F Narváez, Alice Versiani, Diana Fandos, Mauricio L Nogueira, Mohit Singla, Rakesh Lodha, Guruprasad R Medigeshi, Ivette Lorenzana, Hugo Vicente Ralde, Margarita Gélvez-Ramírez, Luis A Villar, Megan Hiley, Laura Mendoza, Nol Salcedo, Bobby Brooke Herrera, Lee Gehrke
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008203 (2020)
BackgroundDengue virus (DENV) infections pose one of the largest global barriers to human health. The four serotypes (DENV 1-4) present different symptoms and influence immune response to subsequent DENV infections, rendering surveillance, risk asses
Externí odkaz:
https://doaj.org/article/5778c22a82e441fe87826d8102e1a0f3
Autor:
Ankita Reddy, Irene Bosch, Nol Salcedo, Bobby Brooke Herrera, Helena de Puig, Carlos F. Narváez, Diana María Caicedo-Borrero, Ivette Lorenzana, Leda Parham, Kimberly García, Marcela Mercado, Angélica María Rico Turca, Luis A. Villar-Centeno, Margarita Gélvez-Ramírez, Natalia Andrea Gómez Ríos, Megan Hiley, Dawlyn García, Michael S. Diamond, Lee Gehrke
Publikováno v:
Viruses, Vol 12, Iss 9, p 971 (2020)
Since its 2013 emergence in the Americas, Chikungunya virus (CHIKV) has posed a serious threat to public health. Early and accurate diagnosis of the disease, though currently lacking in clinics, is integral to enable timely care and epidemiological r
Externí odkaz:
https://doaj.org/article/dec1d277129546eea5052d3c9ad90932
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. Modified nucleotides, whe
Externí odkaz:
https://doaj.org/article/b7b09c582bab42789daa2a9cc4d89add
NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication.
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16687 (2011)
Viral RNA translation and replication are regulated by sequence and structural elements in the 5' and 3' untranslated regions (UTR) and by host cell and/or viral proteins that bind them. Dengue virus has a single-stranded RNA genome with positive pol
Externí odkaz:
https://doaj.org/article/be19e648e75641d68da21775e1cf2da9