Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Lee G Fradkin"'
Autor:
Claire Marquilly, Germain U Busto, Brittany S Leger, Ana Boulanger, Edward Giniger, James A Walker, Lee G Fradkin, Jean-Maurice Dura
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009287 (2021)
Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine tract at the N-terminus of a large cytoplasmic protein. The Drosophila huntingtin (htt) gene is widely expressed during all
Externí odkaz:
https://doaj.org/article/efc38108467142319cba47af0ac17410
Autor:
Arie C van Vliet, Jinhui Lee, Marlijn van der Poel, Matthew R J Mason, Jasprina N Noordermeer, Lee G Fradkin, Martijn R Tannemaat, Martijn J A Malessy, Joost Verhaagen, Fred De Winter
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249748 (2021)
A human neuroma-in continuity (NIC), formed following a peripheral nerve lesion, impedes functional recovery. The molecular mechanisms that underlie the formation of a NIC are poorly understood. Here we show that the expression of multiple genes of t
Externí odkaz:
https://doaj.org/article/c7133a97562842fe8a06a7b4001c0c4e
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008767 (2020)
Despite the importance of dendritic targeting in neural circuit assembly, the mechanisms by which it is controlled still remain incompletely understood. We previously showed that in the developing Drosophila antennal lobe, the Wnt5 protein forms a gr
Externí odkaz:
https://doaj.org/article/b0137b3f2b404bb585d8826c59c1446d
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32297 (2012)
In recent years a number of the genes that regulate muscle formation and maintenance in higher organisms have been identified. Studies employing invertebrate and vertebrate model organisms have revealed that many of the genes required for early mesod
Externí odkaz:
https://doaj.org/article/d3edad8446e2439faacfa7f52da87e45
Autor:
Alice M C van Gemert, Annelies M A van der Laan, Gonneke S K Pilgram, Lee G Fradkin, Jasprina N Noordermeer, Hans J Tanke, Carolina R Jost
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6663 (2009)
BACKGROUND:In skeletal muscle each muscle cell, commonly called myofiber, is actually a large syncytium containing numerous nuclei. Experiments in fixed myofibers show that mRNAs remain localized around the nuclei in which they are produced. METHODOL
Externí odkaz:
https://doaj.org/article/520d98a08b6c4778916ca6cd8c7511e3
Autor:
Mohammed Srahna, Maarten Leyssen, Ching Man Choi, Lee G Fradkin, Jasprina N Noordermeer, Bassem A Hassan
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e348 (2006)
The precise number and pattern of axonal connections generated during brain development regulates animal behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to achieve precise neuronal con
Externí odkaz:
https://doaj.org/article/0646247f33754b348ce739d84612d985
Autor:
Debbie L. L. Ho, Stacey Lee, Jianyi Du, Jonathan D. Weiss, Tony Tam, Soham Sinha, Danielle Klinger, Sean Devine, Art Hamfeldt, Hope T. Leng, Jessica E. Herrmann, Mengdi He, Lee G. Fradkin, Tze Kai Tan, David Standish, Peter Tomasello, Donald Traul, Noushin Dianat, Rukmini Ladi, Quentin Vicard, Kishore Katikireddy, Mark A. Skylar‐Scott
Publikováno v:
Advanced Healthcare Materials. 11:2270149
Autor:
Alessia Soldano, Bart De Strooper, Bassem A. Hassan, Lee G. Fradkin, Lydie Boussicault, Heather C. Rice, Marie-Claude Potier, Iveta M. Petrova, Annelies Claeys, Tengyuan Liu, Maya Nicolas, Tingting Zhang
Publikováno v:
eLife
eLife, 2021, 10, ⟨10.7554/elife.69199⟩
eLife, Vol 10 (2021)
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.69199⟩
eLife, 2021, 10, ⟨10.7554/elife.69199⟩
eLife, Vol 10 (2021)
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.69199⟩
The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and
Autor:
Bart De Strooper, Lee G. Fradkin, Iveta M. Petrova, Alessia Soldano, Marie-Claude Potier, Annelies Claeys, Maya Nicolas, Bassem A. Hassan, Lydie Boussicault, Tengyuan Liu, Heather C. Rice, Tingting Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e102ce6f1f20eedb0c225bd143edc47
https://doi.org/10.7554/elife.69199.sa2
https://doi.org/10.7554/elife.69199.sa2
Autor:
Masamitsu Yamaguchi, Lee G. Fradkin, Saranyapin Potikanond, Graeme W. Davis, Salinee Jantrapirom, Jasprina N. Noordermeer, Wutigri Nimlamool, Somaieh Ahmadian, Piya Temviriyanukul, Cody J. Locke
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:1579-1591
Evolutionarily conserved homeostatic systems have been shown to modulate synaptic efficiency at the neuromuscular junctions of organisms. While advances have been made in identifying molecules that function presynaptically during homeostasis, limited