Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lee F. Willoughby"'
Autor:
Lee F. Willoughby, Tanja Schlosser, Samuel A. Manning, John P. Parisot, Ian P. Street, Helena E. Richardson, Patrick O. Humbert, Anthony M. Brumby
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 521-529 (2013)
SUMMARY Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailable anti-tumour chemicals, the use of appropriate in vivo tumour models suitable for large-scale screening is key.
Externí odkaz:
https://doaj.org/article/e099931ff88e4d07ab0a1bb8e185e7f4
Autor:
Lee F. Willoughby, Helena E. Richardson, Tony Tiganis, Marta Portela, Pei Kee Goh, Kirsten Allan, John E. La Marca
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12732, p 12732 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12732
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12732
International Journal of Molecular Sciences
Tissue homeostasis via the elimination of aberrant cells is fundamental for organism survival. Cell competition is a key homeostatic mechanism, contributing to the recognition and elimination of aberrant cells, preventing their malignant progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd640a89b3afc0164a5e4ee48311e94
https://www.mdpi.com/1422-0067/22/23/12732
https://www.mdpi.com/1422-0067/22/23/12732
Autor:
Helena E. Richardson, Josef M. Penninger, Shane J. F. Cronin, Patrick O. Humbert, Belinda Angjeli, Constantine S. Mitsiades, Ricardo Matos de Simoes, John E. La Marca, Andreas Wernitznig, Kaylene J. Simpson, Sofya Golenkina, Tamara Zoranovic, Lee F. Willoughby, Xia Cuiping, Jan Manent, G. Gregory Neely, Elisabeth Eva Kanitz, Susanne Gruber
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 10, p e1007688 (2018)
PLoS Genetics, Vol 14, Iss 10, p e1007688 (2018)
Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fca51843d0d7c26851f8176237f1fa7
http://europepmc.org/articles/PMC6203380
http://europepmc.org/articles/PMC6203380
Publikováno v:
eLS
The vinegar fly, Drosophila melanogaster, has been a cornerstone of genetic analysis and cell and developmental biology research for over 100 years. Within the last decade, Drosophila is making its mark in translational research in its utilisation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::845086430e166bf96ec7cf000c706bc3
https://doi.org/10.1002/9780470015902.a0022535
https://doi.org/10.1002/9780470015902.a0022535
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 3, Pp 661-678 (2013)
Disease Models & Mechanisms
Disease Models & Mechanisms
SummaryThe Ras oncogene contributes to ~30% of human cancers, but alone is not sufficient for tumorigenesis. In a Drosophila screen for oncogenes that cooperate with an activated allele of Ras (RasACT) to promote tissue overgrowth and invasion, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754b57e7959077008f38fa6c2974c5d1
http://dmm.biologists.org/content/6/3/661
http://dmm.biologists.org/content/6/3/661
Autor:
Helena E. Richardson, Marta Portela, Tzu-Ching Meng, Jan Manent, Tony Tiganis, Coral G. Warr, Han Lee, Florian Wiede, Lee F. Willoughby, Kirsten Allan
Publikováno v:
The FEBS journal. 284(14)
Tyrosine phosphorylation-dependent signalling is coordinated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). There is a growing list of adaptor proteins that interact with PTPs and facilitate the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2471077e02a9f9d984ffc0d6b151b6b8
https://pubmed.ncbi.nlm.nih.gov/28544778
https://pubmed.ncbi.nlm.nih.gov/28544778
Autor:
Nezaket Turkel, Michael J. Murray, Karen Doggett, Jason Ellul, Helena E. Richardson, Anthony M. Brumby, Lee F. Willoughby
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0132987 (2015)
PLoS ONE, Vol 10, Iss 7, p e0132987 (2015)
During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endow tumor cells with cancer stem cell properties. To gain a greater understanding of how these properties are interlinked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5041c1526e26153cf2d5fa3abe4ff980
https://hdl.handle.net/20.500.11831/2330
https://hdl.handle.net/20.500.11831/2330
Autor:
Jason Ellul, Virender K. Sahota, Jessica E. Bolden, Enrique Martin-Blanco, Toshiro Aigaki, Karen Doggett, Helena E. Richardson, Enrique Blanco, Montserrat Corominas, Anthony M. Brumby, Nezaket Turkel, Karen R Goulding, Lee F. Willoughby
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003627 (2013)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS Genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS Genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.
The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal
The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb2ab311cd5fdf918f2fc86ddfa562e
http://europepmc.org/articles/PMC3715428?pdf=render
http://europepmc.org/articles/PMC3715428?pdf=render
Autor:
Ian P. Street, Patrick O. Humbert, Samuel A. Manning, Helena E. Richardson, Tanja Schlosser, Lee F. Willoughby, John P Parisot, Anthony M. Brumby
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 521-529 (2013)
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 521-529 (2013)
Summary Anti-cancer drug development involves enormous expenditure and risk. Key to the rapid and economic identification of novel, bioavailable anti-tumor chemicals is the use of appropriate in vivo tumor models suitable for large-scale screening. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2c21665aad384f55f7e6765891f318
https://pubmed.ncbi.nlm.nih.gov/22996645
https://pubmed.ncbi.nlm.nih.gov/22996645
Autor:
Karen Doggett, Nezaket Turkel, Lee F Willoughby, Jason Ellul, Michael J Murray, Helena E Richardson, Anthony M Brumby
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132987 (2015)
During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endow tumor cells with cancer stem cell properties. To gain a greater understanding of how these properties are interlinked
Externí odkaz:
https://doaj.org/article/1ab12ccb8e4d4afaadea726639471aa5