Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Lee E. Kirsch"'
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1248-1258
The purpose of this work was to determine the degradation pathway of Amphotericin B (AmB) and its kinetics in lipid-based solutions. Mixtures of AmB in lipophilic solvent media were stored under different conditions, such as surface area, temperature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14fdda6a7ddeab767090e4b9b922933
https://doi.org/10.1016/j.xphs.2020.11.004
https://doi.org/10.1016/j.xphs.2020.11.004
Autor:
Phawanan Sawangchan, Francisco Alexandrino Júnior, Éverton N. Alencar, Eryvaldo S.T. Egito, Lee E. Kirsch
Publikováno v:
International Journal of Pharmaceutics. 632:122586
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::961889cfcb8433100b249cb883e92652
https://doi.org/10.1016/j.ijpharm.2023.122586
https://doi.org/10.1016/j.ijpharm.2023.122586
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 146:29-36
Gabapentin was used as a model pharmaceutical compound with susceptibility to polymorphic transformation as a function of environmental and mechanical stress. The utility of 13 C CP/MAS NMR and XRPD as stability-indicating methods to quantify polymor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eda6218bb964641606bcdf8572d5f5d8
https://doi.org/10.1016/j.jpba.2017.07.048
https://doi.org/10.1016/j.jpba.2017.07.048
Autor:
Lee E. Kirsch, Stephen Dion Stamatis
Publikováno v:
AAPS PharmSciTech. 19(7)
A quantitative, model-based risk assessment process was evaluated using Bayesian parameter estimation to determine the posterior distribution of the probability of a model tablet formulation's (gabapentin) ability to meet end-of-expiry stability crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4107b47ac14143a10208d1ddb9d7e1e
https://pubmed.ncbi.nlm.nih.gov/30120695
https://pubmed.ncbi.nlm.nih.gov/30120695
Publikováno v:
AAPS PharmSciTech. 19(7)
The use of particle size distribution (PSD) similarity metrics and the development and incorporation of drug release predictions based on PSD properties into PBPK models for various drug administration routes may provide a holistic approach for evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5524fbc4aa8a827034131d61e303e2
https://pubmed.ncbi.nlm.nih.gov/30117041
https://pubmed.ncbi.nlm.nih.gov/30117041
Publikováno v:
Pharmaceutical Research. 35
The purpose of the research described herein was to develop a kinetic model for quantifying the effects of conditional and compositional variations on non-covalent polymorphic and covalent chemical transformations of gabapentin. Kinetic models that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9aff48730b805d901f4af7209270eb
https://doi.org/10.1007/s11095-017-2285-1
https://doi.org/10.1007/s11095-017-2285-1
In the previous work, a reduced-order population pharmacokinetic (PK) model was used within a Bayesian inference framework to predict individualized patient dosing regimens. It was shown that a reduced-order model was adequate for individualized dosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6609551190aaf39798c7646a3530d33
https://doi.org/10.1016/b978-0-444-63964-6.00005-2
https://doi.org/10.1016/b978-0-444-63964-6.00005-2
Autor:
Salil D. Desai, Lee E. Kirsch
Publikováno v:
International Journal of Chemical Kinetics. 47:471-488
The kinetics of formanilides hydrolysis were determined under first-order conditions in hydrochloric acid (0.01–8 M, 20–60°C) and in hydroxide solutions (0.01–3 M, 25 and 40°C). Under acidic conditions, second-order specific acid catalytic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cf8c419085ae1bad405dd6427338b05
https://doi.org/10.1002/kin.20925
https://doi.org/10.1002/kin.20925
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 146
Gabapentin was used as a model pharmaceutical compound with susceptibility to polymorphic transformation as a function of environmental and mechanical stress. The utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6720d034e94ef21e61db400da8320e6
https://pubmed.ncbi.nlm.nih.gov/28843174
https://pubmed.ncbi.nlm.nih.gov/28843174
Autor:
Zhixin Zong, Lee E. Kirsch, Salil D. Desai, Aditya Mohan Kaushal, Eric J. Munson, Raj Suryanarayanan, Dewey H. Barich, Kassibla Elodie Dempah
Publikováno v:
AAPS PharmSciTech. 14:19-28
Solid-state NMR spectroscopy (SSNMR), coupled with powder X-ray diffraction (PXRD), was used to identify the physical forms of gabapentin in samples prepared by recrystallization, spray drying, dehydration, and milling. Four different crystalline for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1956019abb180b09cbf4e36cda7852c3
https://doi.org/10.1208/s12249-012-9879-z
https://doi.org/10.1208/s12249-012-9879-z