Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lee Dolat"'
Autor:
Robert J Bastidas, Mateusz Kędzior, Robert K Davidson, Stephen C Walsh, Lee Dolat, Barbara S Sixt, Jonathan N Pruneda, Jörn Coers, Raphael H Valdivia
Publikováno v:
eLife, Vol 12 (2024)
Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen Chlamydia
Externí odkaz:
https://doaj.org/article/426a261476c445ab9709280aa9a9f586
Autor:
Lee Dolat, Raphael H Valdivia
Publikováno v:
F1000Research, Vol 8 (2019)
Chlamydia trachomatis is the most prevalent sexually transmitted bacterial pathogen and the leading cause of preventable blindness in the developing world. C. trachomatis invades the epithelium of the conjunctiva and genital tract and replicates with
Externí odkaz:
https://doaj.org/article/18959fc210944807a9869ba198e50821
Autor:
Heather J Tarbet, Lee Dolat, Timothy J Smith, Brett M Condon, E Timothy O'Brien III, Raphael H Valdivia, Michael Boyce
Publikováno v:
eLife, Vol 7 (2018)
Intermediate filaments (IF) are a major component of the metazoan cytoskeleton and are essential for normal cell morphology, motility, and signal transduction. Dysregulation of IFs causes a wide range of human diseases, including skin disorders, card
Externí odkaz:
https://doaj.org/article/40f79e43f1b24224a20c3d64c8d5ebc0
Publikováno v:
mSphere, Vol 2, Iss 4 (2017)
ABSTRACT Chlamydia trachomatis delivers multiple type 3 secreted effector proteins to host epithelial cells to manipulate cytoskeletal functions, membrane dynamics, and signaling pathways. TepP is the most abundant effector protein secreted early in
Externí odkaz:
https://doaj.org/article/1a9812cd31a041fbade3db49bbc9394d
Autor:
Jorge F. Haller, Paul Cavallaro, Nicholas J. Hernandez, Lee Dolat, Stephanie J. Soscia, Ruth Welti, Gregory A. Grabowski, Michael L. Fitzgerald, Mason W. Freeman
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 493-503 (2014)
ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12−/− skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accu
Externí odkaz:
https://doaj.org/article/61096b968579476984c13ed742b53d1c
Autor:
Robert J. Bastidas, Mateusz Kędzior, Lee Dolat, Barbara S. Sixt, Jonathan N. Pruneda, Raphael H. Valdivia
Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Bacterial pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0636a3ffe7ff80f6ccc2e4cc48006bf0
https://doi.org/10.7554/elife.87386
https://doi.org/10.7554/elife.87386
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c41c481ee9a3c216fe3aadbe8f7810
https://doi.org/10.1016/b978-0-12-821618-7.00175-9
https://doi.org/10.1016/b978-0-12-821618-7.00175-9
Publikováno v:
Cancer Research. 83:6195-6195
Chordoma is a rare bone cancer with a high rate of disease recurrence and no approved systemic therapies. Tumor profiling studies indicate a significant number of chordomas are characterized by alterations in SWI/SNF chromatin remodeling and DNA dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5603c0f1d020c94d31749556438ab8ca
https://doi.org/10.1158/1538-7445.am2023-6195
https://doi.org/10.1158/1538-7445.am2023-6195
Publikováno v:
Cancer Research. 83:4865-4865
Target discovery studies have identified EGFR inhibition as a promising therapeutic strategy in chordoma, motivating ongoing clinical trials. Yet EGFR is not mutated in chordoma, leaving the mechanisms associated with EGFR inhibitor (EGFRi) sensitivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::929489deffe2954bcd0de338708da028
https://doi.org/10.1158/1538-7445.am2023-4865
https://doi.org/10.1158/1538-7445.am2023-4865
Autor:
Lauren Davey, Per Malkus, Max Villa, Lee Dolat, Zachary Holmes, Jeffrey Letourneau, Eduard Ansaldo, Lawrence David, Greg Barton, Raphael Valdivia
Akkermansia muciniphila, a prominent member of the gastrointestinal tract (GI) microbiota, uses mucins as a sole source of carbon and nitrogen. A. muciniphila is considered a next-generation probiotic because its abundance in humans positively correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eba24e3e866c85d73b0b36eda908e8f
https://doi.org/10.21203/rs.3.rs-1475049/v1
https://doi.org/10.21203/rs.3.rs-1475049/v1