Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lee Dawson"'
Autor:
Emiliano Tamanini, Shin Miyamura, Ildiko M. Buck, Benjamin D. Cons, Lee Dawson, Charlotte East, Takashi Futamura, Shintaro Goto, Charlotte Griffiths-Jones, Tetsuya Hashimoto, Tom D. Heightman, Shunpei Ishikawa, Hideki Ito, Yosuke Kaneko, Tatsuya Kawato, Kazumi Kondo, Naoki Kurihara, James M. McCarthy, Yukiko Mori, Tsuyoshi Nagase, Yuichiro Nakaishi, Judith Reeks, Akimasa Sato, Patrick Schöpf, Kuninori Tai, Taichi Tamai, Dominic Tisi, Alison J.-A. Woolford
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1591-1597
Fragment-based ligand discovery was successfully applied to histone deacetylase HDAC2. In addition to the anticipated hydroxamic acid- and benzamide-based fragment screening hits, a low affinity (∼1 mM) α-amino-amide zinc binding fragment was iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a51f121f3406b6de752dce46b777833
https://doi.org/10.1021/acsmedchemlett.2c00272
https://doi.org/10.1021/acsmedchemlett.2c00272
Autor:
Pejman Sehatpour, Lee Dawson, Daniel C. Javitt, David H. Margolin, Heloise M. De Baun, Mark Carlton, Roland Bürli, Nicola Brice, Marlene Carlson, Joshua T. Kantrowitz
Publikováno v:
Biological Psychiatry. 89:S27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::433ecc3da4a7ebe5555a7061cdeeeda1
https://doi.org/10.1016/j.biopsych.2021.02.086
https://doi.org/10.1016/j.biopsych.2021.02.086
Autor:
Lorcan Sherry, Richard Bystry, Mark R. Anderson, Sarah-Jane Green, Lee Dawson, Marianne Cowan
Publikováno v:
Cancer Research. 77:2937-2937
Chromogenic-based immunohistochemistry (IHC) is an established technique utilized within oncology R&D, allowing cells to be visualized within the context of their tumor microenvironment. However, when quantifying chromogenic stained sections via digi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178d8e2bc40baa51ef8f71d25d0debf7
https://doi.org/10.1158/1538-7445.am2017-2937
https://doi.org/10.1158/1538-7445.am2017-2937
Autor:
Lee Dawson, David Bowman, Jane Elsom, Justin S. Bryans, Simon H. Ridley, Rosa M. Sancho, Duncan Young, Nigel M. Hooper, Beth Sivyer, Eric Karran, Andy Takle, Michael Hutton
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::632ad7a69585e2ce6e86d23afb529933
https://doi.org/10.1016/j.jalz.2014.05.1728
https://doi.org/10.1016/j.jalz.2014.05.1728
Autor:
Lee Dawson, Roderick A. Porter
Publikováno v:
Small Molecule Therapeutics for Schizophrenia ISBN: 9783319115016
The treatment of schizophrenia has long been dominated by aminergic receptor antagonist-based therapeutics largely founded on the dopamine hypothesis of schizophrenia. More recently the glutamatergic theory has come to the fore which may potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f537ebe3dd5c888f80be08ef5ae7f5
https://doi.org/10.1007/7355_2014_53
https://doi.org/10.1007/7355_2014_53
Publikováno v:
British Journal of Pharmacology. 129:541-546
1. This study examined whether activation of group II metabotropic glutamate (mGlu) receptors in the substantia nigra pars reticulata (SNr) could reverse akinesia in a rodent model of Parkinson's disease (PD). 2. Male Sprague Dawley rats, stereotaxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43faf2f6d3779bac05154aea18d0e103
https://doi.org/10.1038/sj.bjp.0703105
https://doi.org/10.1038/sj.bjp.0703105
Autor:
Lee Dawson, Roderick A. Porter
Publikováno v:
Future medicinal chemistry. 5(13)
The neuropeptide NK3 receptor is expressed almost exclusively within the mammalian nervous system and its localization is commensurate with a role in modulating central monoaminergic neurotransmission. Following on from our previous work we review th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1433da1d198fe3059c26bd221ac7efad
https://pubmed.ncbi.nlm.nih.gov/24024945
https://pubmed.ncbi.nlm.nih.gov/24024945
Autor:
Jonathan Papworth, Alexander Syme, Anthony Groom, Adam Lucas, Lee Dawson, Toshal Patel, Janette Robertson, Jane Gartlon
Publikováno v:
Alzheimer's & Dementia. 8
dementia. Conclusions: Our findings indicate that following cardiac surgery the number of individuals identified as at risk of dementia is much higher than expected in the general population (0.3-0.8% per year) as more than 50% of individuals were af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547b9fb888cd1d90f5b1b667feddd66f
https://doi.org/10.1016/j.jalz.2012.05.2138
https://doi.org/10.1016/j.jalz.2012.05.2138
Autor:
Paschalis Dimopoulos, Andrew Payne, Gregory Keen, Jonathan Papworth, Darren Peter Medland, Ryota Taguchi, Gurpreet S. Bhatia, Eimear Howley, Lee Dawson, Anthony Groom, Peter J. Atkinson, Toshal Patel, Chris Farthing, Laura Barden, Adam Kline, Vishal Sahni, Louise Morgan, Piotr Eisai London Res. Lab. Ltd. Graczyk, Avril Treacy
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee19ef16ebdee15b92fc461a2826c786
https://doi.org/10.1016/j.jalz.2011.05.1900
https://doi.org/10.1016/j.jalz.2011.05.1900
Autor:
Paul Smith, Lee Dawson
Publikováno v:
Recent patents on CNS drug discovery. 3(1)
The neurokinin-3 (NK(3)) is one of the tachykinin peptide neurotransmitter / neuromodulator receptor family. NK(3) receptors are predominantly expressed in neurons of both the peripheral and central nervous systems and in particular, in many of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a81d05a63f8904248eaf058ce9dc4e
https://pubmed.ncbi.nlm.nih.gov/18221236
https://pubmed.ncbi.nlm.nih.gov/18221236