Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Lee D. Spate"'
Autor:
George C. Gabriel, William A. Devine, Bethany K. Redel, Kristin M. Whitworth, Melissa Samuel, Lee D. Spate, Raissa F. Cecil, Randall S. Prather, Yijen L. Wu, Kevin D. Wells, Cecilia W. Lo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The pig is an ideal model system for studying human development and disease due to its similarities to human anatomy, physiology, size, and genome. Further, advances in CRISPR gene editing have made genetically engineered pigs viable models
Externí odkaz:
https://doaj.org/article/93f422a95d7043129581d1f40224dc7b
Autor:
Paula R. Chen, Raymond R. R. Rowland, Ana M. Stoian, Vlad Petrovan, Maureen Sheahan, Charan Ganta, Giselle Cino-Ozuna, Dae Young Kim, James M. Dunleavey, Kristin M. Whitworth, Melissa S. Samuel, Lee D. Spate, Raissa F. Cecil, Joshua A. Benne, Xingyu Yan, Ying Fang, Brad St. Croix, Kelly Lechtenberg, Kevin D. Wells, Randall S. Prather
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR
Externí odkaz:
https://doaj.org/article/2a7f2ae4bfcc4e1b94db3d06a2d64dec
Autor:
Erik A. Koppes, Bethany K. Redel, Marie A. Johnson, Kristen J. Skvorak, Lina Ghaloul-Gonzalez, Megan E. Yates, Dale W. Lewis, Susanne M. Gollin, Yijen L. Wu, Shawn E. Christ, Martine Yerle, Angela Leshinski, Lee D. Spate, Joshua A. Benne, Stephanie L. Murphy, Melissa S. Samuel, Eric M. Walters, Sarah A. Hansen, Kevin D. Wells, Uta Lichter-Konecki, Robert A. Wagner, Joseph T. Newsome, Steven F. Dobrowolski, Jerry Vockley, Randall S. Prather, Robert D. Nicholls
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Phenylalanine hydroxylase–deficient (PAH-deficient) phenylketonuria (PKU) results in systemic hyperphenylalaninemia, leading to neurotoxicity with severe developmental disabilities. Dietary phenylalanine (Phe) restriction prevents the most deleteri
Externí odkaz:
https://doaj.org/article/25a4c7bc5404441d96bc2b097f4c68db
Publikováno v:
Cells, Vol 10, Iss 10, p 2770 (2021)
Genetically modified pigs have become valuable tools for generating advances in animal agriculture and human medicine. Importantly, in vitro production and manipulation of embryos is an essential step in the process of creating porcine models. As the
Externí odkaz:
https://doaj.org/article/ee321f2400e6466c9cd7f382a28a0e1d
Autor:
Paula R Chen, Kyungjun Uh, Kaylynn Monarch, Lee D Spate, Emily D Reese, Randall S Prather, Kiho Lee
Publikováno v:
Biology of Reproduction. 108:611-618
Growth differentiation factor 9 (GDF9) is a secreted protein belonging to the transforming growth factor beta superfamily and has been well characterized for its role during folliculogenesis in the ovary. Although previous studies in mice and sheep h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77dae64ebdc656e629e0040d290bc065
https://doi.org/10.1093/biolre/ioad005
https://doi.org/10.1093/biolre/ioad005
Autor:
Bethany K Redel, Benjamin P Beaton, Lee D Spate, Joshua A Benne, Stephanie L Murphy, Chad W O’Gorman, Anna M Spate, Randall S Prather, Kevin D Wells
Publikováno v:
BioTechniques, Vol 64, Iss 3, Pp 118-124 (2018)
Production of Cas9 mRNA in vitro typically requires the addition of a 5´ cap and 3´ polyadenylation. A plasmid was constructed that harbored the T7 promoter followed by the EMCV IRES and a Cas9 coding region. We hypothesized that the use of the met
Externí odkaz:
https://doaj.org/article/0c50dbd04e8e4a50b5173c1f244c4e26
Autor:
Melissa Samuel, Caroline A Pfeiffer, Destiny N Johns, Matthew C. Lucy, Kevin D. Wells, Melissa A Fudge, Lee D. Spate, Hongyu Liu, Shelbi D Perry, Caroline G Lucas, Paula R Chen, Christine Spinka, Rodney D. Geisert, Thomas E. Spencer, Raissa F. Cecil, Randall S. Prather, Ashley E Meyer
Publikováno v:
Biology of Reproduction. 105:1577-1590
Establishment and maintenance of pregnancy in the pig is a complex process that relies on conceptus regulation of the maternal proinflammatory response to endometrial attachment. Following elongation, pig conceptuses secrete interferon gamma (IFNG) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9337cfc67049fb076cee04b1c05f009a
https://doi.org/10.1093/biolre/ioab186
https://doi.org/10.1093/biolre/ioab186
Publikováno v:
Molecular Reproduction and Development
Glutamine supplementation to porcine embryo culture medium improves development, increases leucine consumption, and enhances mitochondrial activity. In cancer cells, glutamine has been implicated in the activation of mechanistic target of rapamycin c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b737455384324baf251cb96cde89c5bd
https://doi.org/10.1002/mrd.23516
https://doi.org/10.1002/mrd.23516
Autor:
Paula R Chen, Randall S. Prather, Joshua A. Benne, Lee D. Spate, Taylor K. Hord, Raissa F. Cecil, Melissa Samuel
Publikováno v:
Molecular Reproduction and Development
To improve efficiency of somatic cell nuclear transfer (SCNT), it is necessary to modify differentiated donor cells to become more amendable for reprogramming by the oocyte cytoplasm. A key feature that distinguishes somatic/differentiated cells from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768d11a4a3300cecd5c9de56e8b9e589
http://europepmc.org/articles/PMC7496615
http://europepmc.org/articles/PMC7496615
Autor:
Paula R. Chen, Raymond R. R. Rowland, Ana M. Stoian, Vlad Petrovan, Maureen Sheahan, Charan Ganta, Giselle Cino-Ozuna, Dae Young Kim, James M. Dunleavey, Kristin M. Whitworth, Melissa S. Samuel, Lee D. Spate, Raissa F. Cecil, Joshua A. Benne, Xingyu Yan, Ying Fang, Brad St. Croix, Kelly Lechtenberg, Kevin D. Wells, Randall S. Prather
Publikováno v:
Scientific reports. 12(1)
Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR1 as a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22fcc6361fa29d91ad9fa64ebe835b5
https://pubmed.ncbi.nlm.nih.gov/35322150
https://pubmed.ncbi.nlm.nih.gov/35322150