Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Lee D. Spate"'
Autor:
George C. Gabriel, William A. Devine, Bethany K. Redel, Kristin M. Whitworth, Melissa Samuel, Lee D. Spate, Raissa F. Cecil, Randall S. Prather, Yijen L. Wu, Kevin D. Wells, Cecilia W. Lo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The pig is an ideal model system for studying human development and disease due to its similarities to human anatomy, physiology, size, and genome. Further, advances in CRISPR gene editing have made genetically engineered pigs viable models
Externí odkaz:
https://doaj.org/article/93f422a95d7043129581d1f40224dc7b
Autor:
Paula R. Chen, Raymond R. R. Rowland, Ana M. Stoian, Vlad Petrovan, Maureen Sheahan, Charan Ganta, Giselle Cino-Ozuna, Dae Young Kim, James M. Dunleavey, Kristin M. Whitworth, Melissa S. Samuel, Lee D. Spate, Raissa F. Cecil, Joshua A. Benne, Xingyu Yan, Ying Fang, Brad St. Croix, Kelly Lechtenberg, Kevin D. Wells, Randall S. Prather
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR
Externí odkaz:
https://doaj.org/article/2a7f2ae4bfcc4e1b94db3d06a2d64dec
Autor:
Erik A. Koppes, Bethany K. Redel, Marie A. Johnson, Kristen J. Skvorak, Lina Ghaloul-Gonzalez, Megan E. Yates, Dale W. Lewis, Susanne M. Gollin, Yijen L. Wu, Shawn E. Christ, Martine Yerle, Angela Leshinski, Lee D. Spate, Joshua A. Benne, Stephanie L. Murphy, Melissa S. Samuel, Eric M. Walters, Sarah A. Hansen, Kevin D. Wells, Uta Lichter-Konecki, Robert A. Wagner, Joseph T. Newsome, Steven F. Dobrowolski, Jerry Vockley, Randall S. Prather, Robert D. Nicholls
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Phenylalanine hydroxylase–deficient (PAH-deficient) phenylketonuria (PKU) results in systemic hyperphenylalaninemia, leading to neurotoxicity with severe developmental disabilities. Dietary phenylalanine (Phe) restriction prevents the most deleteri
Externí odkaz:
https://doaj.org/article/25a4c7bc5404441d96bc2b097f4c68db
Publikováno v:
Cells, Vol 10, Iss 10, p 2770 (2021)
Genetically modified pigs have become valuable tools for generating advances in animal agriculture and human medicine. Importantly, in vitro production and manipulation of embryos is an essential step in the process of creating porcine models. As the
Externí odkaz:
https://doaj.org/article/ee321f2400e6466c9cd7f382a28a0e1d
Autor:
Paula R Chen, Kyungjun Uh, Kaylynn Monarch, Lee D Spate, Emily D Reese, Randall S Prather, Kiho Lee
Publikováno v:
Biology of Reproduction. 108:611-618
Growth differentiation factor 9 (GDF9) is a secreted protein belonging to the transforming growth factor beta superfamily and has been well characterized for its role during folliculogenesis in the ovary. Although previous studies in mice and sheep h
Autor:
Melissa Samuel, Caroline A Pfeiffer, Destiny N Johns, Matthew C. Lucy, Kevin D. Wells, Melissa A Fudge, Lee D. Spate, Hongyu Liu, Shelbi D Perry, Caroline G Lucas, Paula R Chen, Christine Spinka, Rodney D. Geisert, Thomas E. Spencer, Raissa F. Cecil, Randall S. Prather, Ashley E Meyer
Publikováno v:
Biology of Reproduction. 105:1577-1590
Establishment and maintenance of pregnancy in the pig is a complex process that relies on conceptus regulation of the maternal proinflammatory response to endometrial attachment. Following elongation, pig conceptuses secrete interferon gamma (IFNG) d
Publikováno v:
Molecular Reproduction and Development
Glutamine supplementation to porcine embryo culture medium improves development, increases leucine consumption, and enhances mitochondrial activity. In cancer cells, glutamine has been implicated in the activation of mechanistic target of rapamycin c
Autor:
Paula R Chen, Randall S. Prather, Joshua A. Benne, Lee D. Spate, Taylor K. Hord, Raissa F. Cecil, Melissa Samuel
Publikováno v:
Molecular Reproduction and Development
To improve efficiency of somatic cell nuclear transfer (SCNT), it is necessary to modify differentiated donor cells to become more amendable for reprogramming by the oocyte cytoplasm. A key feature that distinguishes somatic/differentiated cells from
Autor:
Paula R. Chen, Raymond R. R. Rowland, Ana M. Stoian, Vlad Petrovan, Maureen Sheahan, Charan Ganta, Giselle Cino-Ozuna, Dae Young Kim, James M. Dunleavey, Kristin M. Whitworth, Melissa S. Samuel, Lee D. Spate, Raissa F. Cecil, Joshua A. Benne, Xingyu Yan, Ying Fang, Brad St. Croix, Kelly Lechtenberg, Kevin D. Wells, Randall S. Prather
Publikováno v:
Scientific reports. 12(1)
Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR1 as a re
Autor:
Paula R Chen, Bethany K. Redel, Lee D. Spate, Randall S. Prather, Caroline G Lucas, Kevin D. Wells
Publikováno v:
Reprod Toxicol
Pigs have become an important model for agricultural and biomedical purposes. The advent of genomic engineering tools, such as the CRISPR/Cas9 system, has facilitated the production of livestock models with desired modifications. However, precise sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b5051621f2c98bc055507c629d3005
https://europepmc.org/articles/PMC8511169/
https://europepmc.org/articles/PMC8511169/