Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Lee D. Roberts"'
Autor:
Ben D. McNally, Dean F. Ashley, Lea Hänschke, Hélène N. Daou, Nicole T. Watt, Steven A. Murfitt, Amanda D. V. MacCannell, Anna Whitehead, T. Scott Bowen, Francis W. B. Sanders, Michele Vacca, Klaus K. Witte, Graeme R. Davies, Reinhard Bauer, Julian L. Griffin, Lee D. Roberts
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activatio
Externí odkaz:
https://doaj.org/article/e431ba3360bc41d78c30c04a825835be
Autor:
Pim Knuiman, Sam Straw, John Gierula, Aaron Koshy, Lee D. Roberts, Klaus K. Witte, Carrie Ferguson, Thomas Scott Bowen
Publikováno v:
ESC Heart Failure, Vol 8, Iss 2, Pp 898-907 (2021)
Abstract Aims Heart failure with reduced ejection fraction (HFrEF) induces skeletal muscle mitochondrial abnormalities that contribute to exercise limitation; however, specific mitochondrial therapeutic targets remain poorly established. This study q
Externí odkaz:
https://doaj.org/article/048ac35b7ce64482bb14e46a8bd6f7db
Autor:
Faye L. Styles, Moza M. Al-Owais, Jason L. Scragg, Eulashini Chuntharpursat-Bon, Nishani T. Hettiarachchi, Jonathan D. Lippiat, Aisling Minard, Robin S. Bon, Karen Porter, Piruthivi Sukumar, Chris Peers, Lee D. Roberts
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Cellular energy metabolism is fundamental for all biological functions. Cellular proliferation requires extensive metabolic reprogramming and has a high energy demand. The Kv1.3 voltage-gated potassium channel drives cellular proliferation.
Externí odkaz:
https://doaj.org/article/de761f22f16e420bb481b26f474f0f11
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcome
Externí odkaz:
https://doaj.org/article/da6ab08961324858bf419780f90c8fa2
Autor:
Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have ant
Externí odkaz:
https://doaj.org/article/d473c1c97b044c2fb72f34ce9316e47f
Autor:
Nathanael Wood, Sam Straw, Mattia Scalabrin, Lee D. Roberts, Klaus K. Witte, Thomas Scott Bowen
Publikováno v:
ESC Heart Failure, Vol 8, Iss 1, Pp 3-15 (2021)
Abstract Two highly prevalent and growing global diseases impacted by skeletal muscle atrophy are chronic heart failure (HF) and type 2 diabetes mellitus (DM). The presence of either condition increases the likelihood of developing the other, with re
Externí odkaz:
https://doaj.org/article/0dacf6695fe145fe96f329cacb88e338
Autor:
Fiona Bartoli, Marjolaine Debant, Eulashini Chuntharpursat-Bon, Elizabeth L. Evans, Katie E. Musialowski, Gregory Parsonage, Lara C. Morley, T. Simon Futers, Piruthivi Sukumar, T. Scott Bowen, Mark T. Kearney, Laeticia Lichtenstein, Lee D. Roberts, David J. Beech
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 i
Externí odkaz:
https://doaj.org/article/7a5506da60ec4fa4ab0afb685437f3d2
Autor:
Jack O. Garnham, Lee D. Roberts, Ever Espino‐Gonzalez, Anna Whitehead, Peter P. Swoboda, Aaron Koshy, John Gierula, Maria F. Paton, Richard M. Cubbon, Mark T. Kearney, Stuart Egginton, T. Scott Bowen, Klaus K. Witte
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 394-404 (2020)
Abstract Background Patients with coexistent chronic heart failure (CHF) and diabetes mellitus (DM) demonstrate greater exercise limitation and worse prognosis compared with CHF patients without DM, even when corrected for cardiac dysfunction. Unders
Externí odkaz:
https://doaj.org/article/101916830bde42eb8824f3cbd45b7138
Autor:
Jack O. Garnham, Lee D. Roberts, Talia Caspi, Moza M. Al‐Owais, Max Bullock, Peter P. Swoboda, Aaron Koshy, John Gierula, Maria F. Paton, Richard M. Cubbon, Mark T. Kearney, T. Scott Bowen, Klaus K. Witte
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 79-88 (2020)
Abstract Background Previous studies in heart failure with reduced ejection fraction (HFrEF) suggest that skeletal muscle mitochondrial impairments are associated with exercise intolerance in men. However, the nature of this relationship in female pa
Externí odkaz:
https://doaj.org/article/37c20e4c9e3045ec9d52f327fafff6f4
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100005- (2021)
Externí odkaz:
https://doaj.org/article/28ee3111dbbf4709baa597524833b13c