Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Lee Collier"'
Publikováno v:
Journal of Pediatrics: Clinical Practice, Vol 11, Iss , Pp 200105- (2024)
Externí odkaz:
https://doaj.org/article/963821694967416e91717ee39028ec93
Autor:
Zhen Chen, Jiahui Chen, Laigao Chen, Chi-Hyeon Yoo, Jian Rong, Hualong Fu, Tuo Shao, Karen Coffman, Stefanus J. Steyn, April T. Davenport, James B. Daunais, Ahmed Haider, Lee Collier, Lee Josephson, Hsiao-Ying Wey, Lei Zhang, Steven H. Liang
Publikováno v:
Journal of Medicinal Chemistry. 66:1712-1724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6c64f6296ede2568d7df7103162b79
https://doi.org/10.1021/acs.jmedchem.2c00551
https://doi.org/10.1021/acs.jmedchem.2c00551
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2922-2927 (2017)
Continuous-flow microfluidics has shown increased applications in radiochemistry over the last decade, particularly for both pre-clinical and clinical production of fluorine-18 labeled radiotracers. The main advantages of microfluidics are the reduct
Externí odkaz:
https://doaj.org/article/f2d3b8f0f0bc4f6984684e32c5bebcdd
Autor:
Thomas Lee Collier, Marc D. Normandin, Nickeisha A. Stephenson, Eli Livni, Steven H. Liang, Dustin W. Wooten, Shadi A. Esfahani, Michael G. Stabin, Umar Mahmood, Jianqing Chen, Wei Wang, Kevin Maresca, Rikki N. Waterhouse, Georges El Fakhri, Paul Richardson, Neil Vasdev
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Lorlatinib—a ROS1/ALK inhibitor—is currently undergoing clinical trials for the treatment of non-small cell lung cancers. Here the authors develop synthetic routes to11C- and 18F-labelled lorlatinib, with subsequent PET imaging showing good blood
Externí odkaz:
https://doaj.org/article/c6a81b2a14fd4e259767853846c7c586
Autor:
Ahmed Haider, Jian Rong, Steven H. Liang, Huiyi Wei, Daisuke Ogasawara, Masayuki Fujinaga, Tuo Shao, Wakana Mori, Shuyin Gu, Hao Xu, Michael A. Schafroth, Lin Xie, Yuancheng Gou, Ming-Rong Zhang, Thomas Lee Collier, Jiahui Chen, Katsushi Kumata, Zhen Chen, Richard Van, Yihan Shao, Lu Wang, Zhiwei Xiao, Xiaotian Xia, Kuan Hu, Bao Liang, Tomoteru Yamasaki, Richard E. Carson, Yiding Zhang, Fuwen Pang, Benjamin F. Cravatt, Yang Fang, Chunyu Zhao, Atsuto Hiraishi
Publikováno v:
J Med Chem
Monoacylglycerol lipase (MAGL) is a 33 kDa serine protease primarily responsible for hydrolyzing 2-arachidonoylglycerol into the proinflammatory eicosanoid precursor arachidonic acid in the central nervous system. Inhibition of MAGL constitutes an at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d13650994fb578b1cd216abc002e41f
https://doi.org/10.1021/acs.jmedchem.1c00747
https://doi.org/10.1021/acs.jmedchem.1c00747
Autor:
T. Lee Collier PhD, Kevin P. Maresca PhD, Marc D. Normandin PhD, Paul Richardson PhD, Timothy J. McCarthy PhD, Steven H. Liang PhD, Rikki N. Waterhouse PhD, Neil Vasdev PhD
Publikováno v:
Molecular Imaging, Vol 16 (2017)
The Massachusetts General Hospital Radiochemistry Program, in collaboration with Pfizer, has developed unique 11 C and 18 F-labeling strategies to synthesize isotopologs of lorlatinib (PF-06463922) which is undergoing phase III clinical trial investi
Externí odkaz:
https://doaj.org/article/27b95e925c124ac8b0c0adf8168291a3
Autor:
Yiding Zhang, Jiahui Chen, Atsuto Hiraishi, Steven H. Liang, Tomoteru Yamasaki, Ming-Rong Zhang, Benjamin F. Cravatt, Wakana Mori, Lee Josephson, Richard Van, Jian Rong, Tuo Shao, Masayuki Fujinaga, Michael A. Schafroth, Akiko Hatori, Thomas Lee Collier, Jiyun Sun, Qingzhen Yu, Kuan Hu, Zhen Chen, Yihan Shao, Daisuke Ogasawara
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1686-1695 (2021)
As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dc81ff1372e31f66e3ce1732636ba4
http://www.sciencedirect.com/science/article/pii/S2211383521000381
http://www.sciencedirect.com/science/article/pii/S2211383521000381
Autor:
Xiao, Zhiwei, Sun, Jiyun, Masayuki, Fujinaga, Zhao, Chunyu, Haider Haider, Ahmed, Rong, Jian, Shao, Yihan, Lee Collier, Thomas, C Kent Lloyd, K, Lu, Wang, Zhang, Ming-Rong, Liang, Steven
Publikováno v:
Nuclear Medicine and Biology.
Background: The intracellular second messengers, cAMP and cGMP, play a substantial role in signal transduction pathways involving a myriad of processes in the central nervous system (CNS), immune system, and cardiovascular system. Cyclic nucleotide p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::77f43d9300befbbd010daaab53668c1c
https://repo.qst.go.jp/records/86450
https://repo.qst.go.jp/records/86450
Autor:
Rong, Jian, Tomoteru, Yamasaki, Zhao, Chunyu, Chen, Jiahui, Zhiwei, Xiao, Li, Yinlong, Lee Collier, Thomas, Zhang, Ming-Rong, Liang, Steven
Publikováno v:
Nuclear Medicine and Biology.
Objectives: The orexin network mainly relies on two G protein-coupled receptors, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R), and two neuropeptides, orexin-A (a 33 amino acid peptide) and orexin-B (a 28 amino acid peptide). Orexin-A is a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::0ff256f63724adeea66cac3bc1759f0a
https://repo.qst.go.jp/records/86452
https://repo.qst.go.jp/records/86452
Autor:
A. Yu, Qingzhen, Katsushi, Kumata, Lee Collier, Thomas, Tomita, Susumu, Zhang, Ming-Rong, Liang, Steven
Publikováno v:
Nuclear Medicine and Biology.
Objectives: Transmembrane AMPA receptor regulatory proteins subtype γ8 (TARP γ8) exhibits regiospecific expression in the brain, which could serve as a potential therapeutic target for central nervous system disorders with high selectivity. Based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::ac515fd72fb9f60c30c2e440f9e8b193
https://repo.qst.go.jp/records/86451
https://repo.qst.go.jp/records/86451