Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Lee Chuan C Yeh"'
Autor:
Alexander L. Weis, Veena Prasad, I-Tien Yeh, Asok Banerjee, John C. Lee, Richard F. Ludueña, Lee Chuan C Yeh, Tamas Bakos, Jack A. Tuszynski
Publikováno v:
Investigational New Drugs. 34:129-137
The subunit protein of microtubules is tubulin, which has been the target for some of the most successful and widely used anti-tumor drugs. Most of the drugs that target tubulin bind to the β subunit. There are many isotypes of β-tubulin and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3221646c0bd2c3f220687e320a0a5d6b
https://doi.org/10.1007/s10637-015-0315-6
https://doi.org/10.1007/s10637-015-0315-6
Publikováno v:
Biochemical and Biophysical Research Communications. 450:777-781
Aging is associated with the accumulation of ectopic lipid resulting in the inhibition of normal organ function, a phenomenon known as lipotoxicity. Within the bone marrow microenvironment, elevation in fatty acid levels may produce an increase in os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a13f9707167393e9bc060b2a8fcfea
https://doi.org/10.1016/j.bbrc.2014.06.063
https://doi.org/10.1016/j.bbrc.2014.06.063
Publikováno v:
Journal of Cellular Biochemistry. 114:1760-1771
Bone morphogenetic proteins (BMPs) promote osteoblast differentiation and bone formation in vitro and in vivo. BMPs canonically signal through Smad transcription factors, but BMPs may activate signaling pathways traditionally stimulated by growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2d5c378cbe71988b241f44aec2b885
https://doi.org/10.1002/jcb.24519
https://doi.org/10.1002/jcb.24519
Publikováno v:
Growth Factors. 27:121-131
Bone remodeling is a process consisting of bone formation and resorption. The present study compared the relative osteoclastic and osteoblastic potency of bone morphogenetic proteins (BMP)-2, -4, -5, -6, and -7 in primary murine bone marrow cultures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4977738b946ad543e830e0cfb3f27a5
https://doi.org/10.1080/08977190802707324
https://doi.org/10.1080/08977190802707324
Characterization of Ligand-Binding Properties of the Human BMP Type II Receptor Extracellular Domain
Publikováno v:
Journal of Molecular Biology. 378:191-203
ActR-IIA, ActR-IIB, and BMPR-II are low-affinity type II receptors that bind bone morphogenetic proteins (BMPs) in the same overall manner. The binding of BMPs by ActR-IIs has been analyzed structurally and functionally, but no detailed analysis of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063c45202e27002786aeae9d12f59409
https://doi.org/10.1016/j.jmb.2008.02.031
https://doi.org/10.1016/j.jmb.2008.02.031
Publikováno v:
Biochemistry. 54(48)
Protein-protein interactions are recognized as a fundamental phenomenon that is intimately associated with biological functions and thus are ideal targets for developing modulators for regulating biological functions. A challenge is to identify a sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961edbf7b2f27f979a9ad86a527b63f1
https://pubmed.ncbi.nlm.nih.gov/26562759
https://pubmed.ncbi.nlm.nih.gov/26562759
In the current study, we determined the effects of IGF-1 receptor haploinsufficiency on osteoblast differentiation and bone formation throughout the lifespan. Bone mineral density was significantly decreased in femurs of male and female Igf1r(+/-) mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcbaea8e73a1b80da69c54aa3da6719
https://europepmc.org/articles/PMC4511128/
https://europepmc.org/articles/PMC4511128/
Publikováno v:
Journal of Cellular Biochemistry. 98:1196-1202
Retinal pigment epithelial (RPE) cells secrete vascular endothelial growth factor (VEGF), a cytokine known to promote angiogenesis. Results from RNase protection assays (RPAs) show that RPE from non-diabetic human donors and from adult retinal pigmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1f72eacc711446fa7105fb4058688f
https://doi.org/10.1002/jcb.20831
https://doi.org/10.1002/jcb.20831
Publikováno v:
Journal of Cellular Biochemistry. 95:173-188
Cartilage-derived morphogenetic protein-1, -2, and -3 (CDMP-1, -2, and -3) are members of the bone morphogenetic protein (BMP) family and have been shown to exhibit a variety of biological activities. In the present study, effects of these CDMPs on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eb4142fd977cdd18fe324a9fc4068b
https://doi.org/10.1002/jcb.20402
https://doi.org/10.1002/jcb.20402
Publikováno v:
Journal of Cellular Physiology. 191:298-309
The mRNA expression patterns of several bone morphogenetic proteins (BMPs) and growth differentiation factors (GDFs) in long-term cultures of the clonal mouse chondrocyte cell line MC615 were examined. Distinct spatial and temporal patterns of expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa40d1c247f389a6d80dc3885098198
https://doi.org/10.1002/jcp.10094
https://doi.org/10.1002/jcp.10094