BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice.

Autor: Lee CYD, De La Rocha AJ, Inouye K, Langfelder P, Daggett A, Gu X, Jiang LL, Pamonag Z, Vaca RG, Richman J, Kawaguchi R, Gao F, Xu H, Yang XW

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 05. Date of Electronic Publication: 2023 Aug 05.

Network dynamics-based subtyping of Alzheimer's disease with microglial genetic risk factors.

Autor: Choi, Jae Hyuk¹ (AUTHOR), Lee, Jonghoon¹ (AUTHOR), Kang, Uiryong¹ (AUTHOR), Chang, Hongjun¹ (AUTHOR), Cho, Kwang-Hyun¹ (AUTHOR) ckh@kaist.ac.kr

Publikováno v: Alzheimer's Research & Therapy. 10/16/2024, Vol. 16 Issue 1, p1-20. 20p.

Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients.

Autor: Lee CYD; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Wang N; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Shen K; Department of Biology and BioX Program, Stanford University, Stanford, CA, USA.; Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA., Stricos M; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Langfelder P; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Cheon KH; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Cortés EP; Division of Aging and Dementia, Department of Neurology, Columbia University Medical Center, New York, NY, USA., Vinters HV; Department of Pathology and Laboratory Medicine, Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Vonsattel JP; Division of Aging and Dementia, Department of Neurology, Columbia University Medical Center, New York, NY, USA., Wexler NS; Departments of Neurology and Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Hereditary Disease Foundation, New York, NY, USA., Damoiseaux R; California NanoSystems Institute, University of California, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA., Frydman J; Department of Biology and BioX Program, Stanford University, Stanford, CA, USA., Yang XW; Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA. xwyang@mednet.ucla.edu.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. xwyang@mednet.ucla.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Nov 20; Vol. 10 (1), pp. 20295. Date of Electronic Publication: 2020 Nov 20.

Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis.

Autor: Yang, Shaobin¹ (AUTHOR) yangshaobin@nwnu.edu.cn, Du, Yaqin¹ (AUTHOR), Li, Yanhong¹ (AUTHOR), Tang, Qi¹ (AUTHOR), Zhang, Yimeng¹ (AUTHOR), Zhao, Xiaoqian¹ (AUTHOR)

Publikováno v: Journal of Neuroinflammation. 9/3/2024, Vol. 21 Issue 1, p1-19. 19p.

Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion model.

Autor: Lee, Ji-Won¹ (AUTHOR) jwlee@den.hokudai.ac.jp, Mizuno, Kaito^1,2 (AUTHOR), Watanabe, Haruhisa^3,4 (AUTHOR), Lee, In-Hee⁵ (AUTHOR), Tsumita, Takuya⁶ (AUTHOR), Hida, Kyoko⁶ (AUTHOR), Yawaka, Yasutaka² (AUTHOR), Kitagawa, Yoshimasa⁴ (AUTHOR), Hasebe, Akira¹ (AUTHOR), Iimura, Tadahiro³ (AUTHOR), Kong, Sek Won^5,7 (AUTHOR)

Publikováno v: Journal of Neuroinflammation. 8/6/2024, Vol. 21 Issue 1, p1-19. 19p.