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Akademický článek

High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

Autor: Afshin Saffari, Barbara Brechmann, Cedric Böger, Wardiya Afshar Saber, Hellen Jumo, Dosh Whye, Delaney Wood, Lara Wahlster, Julian E. Alecu, Marvin Ziegler, Marlene Scheffold, Kellen Winden, Jed Hubbs, Elizabeth D. Buttermore, Lee Barrett, Georg H. H. Borner, Alexandra K. Davies, Darius Ebrahimi-Fakhari, Mustafa Sahin

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect therapeutic targets for rare diseases. In this study, we developed a high-throughput screening assay to identify molecules that correct aberrant pro

Externí odkaz: https://doaj.org/article/b52e18bceed849439f7ec10f0de5714b

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Akademický článek

Moral Implications of Augustine's Philosophical and Spiritual Journey in his Confessiones

Autor: Michal Valco, Roman Kralik, Lee Barrett

Publikováno v: Communications, Vol 17, Iss 2, Pp 103-108 (2015)

Aurelius Augustinus, though born to a Christian mother, had undergone a long and tedious spiritual journey in his search for truth and meaning. Youthful hedonism gave way to Skepticism, Manichaeism, and later on to Neo-Platonism as he searched for an

Externí odkaz: https://doaj.org/article/873993f898df4ad7840c991166696a5f

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Akademický článek

Food insecurity among homeless and precariously housed children in the United States : Lessons from the past

Autor: Lee, Barrett A., Lippert, Adam M.

Publikováno v: Demographic Research, 2021 Jul 01. 45, 1115-1148.

Externí odkaz: https://www.jstor.org/stable/48640808

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Akademický článek

Forced to move: Patterns and predictors of residential displacement during an era of housing insecurity

Autor: Lee, Barrett A., Evans, Megan

Publikováno v: In Social Science Research March 2020 87

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Akademický článek

Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

Autor: Richard Lee Barrett, Ellen Puré

Publikováno v: eLife, Vol 9 (2020)

Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture and function. Growth in most solid tumors is dependent upon remodeling ‘stroma’, composed of cancer-associated fibroblasts (CAFs) and extracellular matri

Externí odkaz: https://doaj.org/article/f82d5c2d669f4c00945df4da80cc4f6e

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