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Autor:
Robert W. King, Helen Scarnati, Lee Bachelor, Sena Garber, Sylvia Stack, Dean L. Winslow, M. J. Otto
Publikováno v:
Antiviral Research. 28:13-24
The HIV-1 protease (PR) is essential for the production of mature virions. As such, it has become a target for the development of anti-HIV chemotherapeutics. Multiple passages of virus in cell culture in the presence of PR inhibitors have resulted in