Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lee B. Bockus"'
Autor:
Lee B. Bockus, Satoshi Matsuzaki, Shraddha S. Vadvalkar, Zachary T. Young, Jennifer R. Giorgione, Maria F. Newhardt, Michael Kinter, Kenneth M. Humphries
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)
BackgroundThe healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Diabetes mellitus disrupts this metabolic flexibility and promotes cardiomyopathy through mechanisms that are not completely understood. Phos
Externí odkaz:
https://doaj.org/article/16b32246753649a0b935f2759f21a632
Publikováno v:
The American Journal of the Medical Sciences. 357:164-167
The presenting symptoms of diabetic ketoacidosis (DKA) include abdominal pain, polyuria and nausea. Diabetes has well known chronic ocular complications like glaucoma, cataracts and retinopathy. We report a case of reversible blindness as a presentin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc34688ab9a6b9e98d063678156cc4f7
https://doi.org/10.1016/j.amjms.2018.09.013
https://doi.org/10.1016/j.amjms.2018.09.013
Autor:
Marcia C. de Olivera Otto, Xiaoling Song, Rozenn N. Lemaitre, Mary L. Biggs, David S. Siscovick, Amanda M. Fretts, Lee B. Bockus, Dariush Mozaffarian, Nona Sotoodehnia, Heidi Lai, Barbara McKnight, Irena B. King
Publikováno v:
JAMA Netw Open
Importance Identifying novel factors that protect against age-related diseases and promote healthy aging is critical to public health. Higher levels of circulating very-long-chain saturated fatty acids (VLSFAs) are integrated biomarkers of diet and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2565e23ca7a3f297dd4f1e6133d5d836
https://doi.org/10.1001/jamanetworkopen.2021.20616
https://doi.org/10.1001/jamanetworkopen.2021.20616
Autor:
Kenneth M. Humphries, Jennifer R. Giorgione, Satoshi Matsuzaki, Michael Kinter, Caroline S. Kinter, Lee B. Bockus, Shraddha S. Vadvalkar, Craig Eyster
Publikováno v:
Journal of Biological Chemistry. 292:4423-4433
Alterations in mitochondrial function contribute to diabetic cardiomyopathy. We have previously shown that heart mitochondrial proteins are hyperacetylated in OVE26 mice, a transgenic model of type 1 diabetes. However, the universality of this modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e7e661b343b037276eea34caf784757
https://doi.org/10.1074/jbc.m116.753509
https://doi.org/10.1074/jbc.m116.753509
Autor:
Lee B. Bockus, Kenneth M. Humphries
Publikováno v:
Journal of Biological Chemistry. 290:29250-29258
Diabetes mellitus causes cardiac dysfunction and heart failure that is associated with metabolic abnormalities and autonomic impairment. Autonomic control of ventricular function occurs through regulation of cAMP-dependent protein kinase (PKA). The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d11955b202db05a05147152a2aef932
https://doi.org/10.1074/jbc.m115.681767
https://doi.org/10.1074/jbc.m115.681767
Autor:
Shraddha S. Vadvalkar, Maria F. Newhardt, Lee B. Bockus, Michael Kinter, Zachary T. Young, Jennifer R. Giorgione, Kenneth M. Humphries, Satoshi Matsuzaki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Diabetes mellitus disrupts this metabolic flexibility and promotes cardiomyopathy through mechanisms that are not completely understood. Pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1efd423e79f192f0d0802a93914765
https://doi.org/10.1161/jaha.117.007159
https://doi.org/10.1161/jaha.117.007159
Autor:
R. Hal Scofield, Lee B. Bockus
Publikováno v:
Methods in Molecular Biology ISBN: 9781493927173
The reversible phosphorylation of phosphoproteins is a vital regulatory process for many cellular pathways. A reliable and simple fluorescent detection technique for phosphoproteins has been developed using a small-molecule organic fluorophore, Pro-Q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f92170569c69db4cffdd3046d43b0d35
https://doi.org/10.1007/978-1-4939-2718-0_27
https://doi.org/10.1007/978-1-4939-2718-0_27
Autor:
Kenneth M. Humphries, Lee B. Bockus
Publikováno v:
Circulation. 130
Autonomic control of cardiac function primarily occurs through the regulation of cAMP-dependent protein kinase (PKA) via the adrenergic and muscarinic pathways. The diabetic heart has a suppressed β-adrenergic response that is classically attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8daa9bf2fe8bedc55bf7ccd6e7bb8cec
https://doi.org/10.1161/circ.130.suppl_2.20504
https://doi.org/10.1161/circ.130.suppl_2.20504