Automated preclinical detection of mechanical pain hypersensitivity and analgesia

Autor: Zihe Zhang, David P. Roberson, Masakazu Kotoda, Bruno Boivin, James P. Bohnslav, Rafael González-Cano, David A. Yarmolinsky, Bruna Lenfers Turnes, Nivanthika K. Wimalasena, Shay Q. Neufeld, Lee B. Barrett, Nara L. M. Quintão, Victor Fattori, Daniel G. Taub, Alexander B. Wiltschko, Nick A. Andrews, Christopher D. Harvey, Sandeep Robert Datta, Clifford J. Woolf

The lack of sensitive and robust behavioral assessments of pain in preclinical models has been a major limitation for both pain research and the development of novel analgesics. Here, we demonstrate a novel data acquisition and analysis platform that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588f871a1fe1763ad305dec0c5e18f1d
https://hdl.handle.net/10481/78398

Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons

Autor: Tammy Szu-Yu Ho, J. Tabitha Hees, Zhuqiu Xu, Riki Kawaguchi, Natalia P. Biscola, Daniel G Taub, Kuchuan Chen, Xirui Chen, Lee B. Barrett, Long Cheng, Christopher V. Gabel, Leif A. Havton, Daniel H. Geschwind, Clifford J. Woolf

SummaryCNS neurons do not regenerate after injury, leading to permanent functional deficits. Although sensory and motor neuron axons do regrow after peripheral nerve injury, functional outcome is limited due to the incomplete and slow regrowth. The l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e159f8008a764a2e520e980818808483
https://doi.org/10.1101/2021.11.02.466937

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

Autor: Isaac M Chiu, Lee B Barrett, Erika K Williams, David E Strochlic, Seungkyu Lee, Andy D Weyer, Shan Lou, Gregory S Bryman, David P Roberson, Nader Ghasemlou, Cara Piccoli, Ezgi Ahat, Victor Wang, Enrique J Cobos, Cheryl L Stucky, Qiufu Ma, Stephen D Liberles, Clifford J Woolf

Publikováno v: eLife, Vol 3 (2014)

The somatosensory nervous system is critical for the organism's ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and anatomically diverse but their molecular profiles are not well-defined. Her

Externí odkaz: https://doaj.org/article/bc65ad0efece430bb716d97cb8616581

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1

Autor: Michael, Costigan, Inna, Belfer, Robert S, Griffin, Feng, Dai, Lee B, Barrett, Giovanni, Coppola, Tianxia, Wu, Carly, Kiselycznyk, Minakshi, Poddar, Yan, Lu, Luda, Diatchenko, Shad, Smith, Enrique J, Cobos, Dmitri, Zaykin, Andrew, Allchorne, Edith, Gershon, Jessica, Livneh, Pei-Hong, Shen, Lone, Nikolajsen, Jaro, Karppinen, Minna, Männikkö, Anthi, Kelempisioti, David, Goldman, William, Maixner, Daniel H, Geschwind, Mitchell B, Max, Ze'ev, Seltzer, Clifford J, Woolf

Publikováno v: Costigan, M, Belfer, I, Griffin, R S, Dai, F, Barrett, L B, Coppola, G, Wu, T, Kiselycznyk, C, Poddar, M, Lu, Y, Diatchenko, L, Smith, S, Cobos, E J, Zaykin, D, Allchorne, A, Shen, P-H, Nikolajsen, L, Karppinen, J, Männikkö, M, Kelempisioti, A, Goldman, D, Maixner, W, Geschwind, D H, Max, M B, Seltzer, Z & Woolf, C J 2010, ' Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1 ', Brain, vol. 133, pp. 2519 . https://doi.org/10.1093/brain/awq195

Not all patients with nerve injury develop neuropathic pain. The extent of nerve damage and age at the time of injury are two of the few risk factors identified to date. In addition, preclinical studies show that neuropathic pain variance is heritabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f0bae7b36b1e05b19d7522cb9246f9
https://pure.au.dk/portal/da/publications/multiple-chronic-pain-states-are-associated-with-a-common-amino-acidchanging-allele-in-kcns1(6e12cd00-b430-11df-8c1a-000ea68e967b).html

Straight talk: new approaches in health care. HIPAA: deadlines are looming. Are providers prepared?

Autor: Jeffrey P, Fusile, George S, Arges, Lee B, Barrett

Publikováno v: Modern healthcare. 32(25)

This is the fourth installment in a series of group discussions by top executives on key issues in healthcare today. Modern Healthcare and PricewaterhouseCoopers present Straight Talk. This session tackles the Health Insurance Portability and Account

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54a6e2b086ae43870568114d600a92c6
https://pubmed.ncbi.nlm.nih.gov/12120431