Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lee A. Newberg"'
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193067 (2018)
Bulk tissue samples examined by gene expression studies are usually heterogeneous. The data gained from these samples display the confounding patterns of mixtures consisting of multiple cell types or similar cell types in various functional states, w
Externí odkaz:
https://doaj.org/article/3e93fb200b6d4fe7becd1224444fa83e
Autor:
Matthew Newby, Malik Magdon-Ismail, Lawrence M. Widrow, Matthew Arsenault, Siddhartha Shelton, Jacob S. Bauer, Heidi Jo Newberg, Roland Judd, Lee A. Newberg, Travis Desell, Boleslaw K. Szymanski, Clayton Rayment, Benjamin A. Willett, Jake Weiss, Carlos A. Varela, Colin Rice, Steve Ulin, Jeffery M. Thompson, Eric Mendelsohn
Publikováno v:
Proceedings of the International Astronomical Union. 14:75-82
We describe an algorithm that can fit the properties of the dwarf galaxy progenitor of a tidal stream, given the properties of that stream. We show that under ideal conditions (the Milky Way potential, the orbit of the dwarf galaxy progenitor, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71cf0747bedb5e4b2acb599180e2c4b8
https://doi.org/10.1017/s174392131900855x
https://doi.org/10.1017/s174392131900855x
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193067 (2018)
PLoS ONE
PLoS ONE
Bulk tissue samples examined by gene expression studies are usually heterogeneous. The data gained from these samples display the confounding patterns of mixtures consisting of multiple cell types or similar cell types in various functional states, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85c22403db0dee4413f364e4c87371a
http://europepmc.org/articles/PMC5832224?pdf=render
http://europepmc.org/articles/PMC5832224?pdf=render
Autor:
Michael J. Palumbo, Lee A. Newberg
Publikováno v:
Nucleic Acids Research
The transcription of a gene from its DNA template into an mRNA molecule is the first, and most heavily regulated, step in gene expression. Especially in bacteria, regulation is typically achieved via the binding of a transcription factor (protein) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4d08ad1cff8e54b7e7f043ed2a1174
https://doi.org/10.1093/nar/gkq330
https://doi.org/10.1093/nar/gkq330
Autor:
Lee A. Newberg, Charles E. Lawrence
Publikováno v:
Journal of Computational Biology. 16:1-18
Computational biology is replete with high-dimensional discrete prediction and inference problems. Dynamic programming recursions can be applied to several of the most important of these, including sequence alignment, RNA secondary-structure predicti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d9c702f95562c9dd558b86f0c54651
https://doi.org/10.1089/cmb.2008.0137
https://doi.org/10.1089/cmb.2008.0137
Autor:
Lee A. Newberg
Publikováno v:
Journal of Computational Biology. 15:1187-1194
Measurement of the the statistical significance of extreme sequence alignment scores is key to many important applications, but it is difficult. To precisely approximate alignment score significance, we draw random samples directly from a well chosen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5be5f0aa9b809842646555b7f77443
https://doi.org/10.1089/cmb.2008.0125
https://doi.org/10.1089/cmb.2008.0125
Autor:
Charles E. Lawrence, Sean Conlan, William Thompson, Thomas M. Smith, Lee Ann McCue, Lee A. Newberg
Publikováno v:
Bioinformatics. 23:1718-1727
Motivation: Identification of functionally conserved regulatory elements in sequence data from closely related organisms is becoming feasible, due to the rapid growth of public sequence databases. Closely related organisms are most likely to have com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9438ba12cbc456ce9170ea1c5fd593e
https://doi.org/10.1093/bioinformatics/btm241
https://doi.org/10.1093/bioinformatics/btm241
Publikováno v:
Nucleic Acids Research
The Gibbs Centroid Sampler is a software package designed for locating conserved elements in biopolymer sequences. The Gibbs Centroid Sampler reports a centroid alignment, i.e. an alignment that has the minimum total distance to the set of samples ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4de8f6bb968a03ce869d67e83a9d80
https://doi.org/10.1093/nar/gkm265
https://doi.org/10.1093/nar/gkm265
Publikováno v:
BIBM
The era of precision medicine is best exemplified by the growing reliance on next-generation sequencing (NGS) technologies to provide improved disease diagnosis and targeted therapeutic selection. Well-established NGS data analysis software tools, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3fe588dc73d2e477192c14117275f90
https://doi.org/10.1109/bibm.2015.7359781
https://doi.org/10.1109/bibm.2015.7359781
Autor:
Charles E. Lawrence, Lee A. Newberg
Publikováno v:
Statistical Applications in Genetics and Molecular Biology. 3:1-12
Under the assumption that a significant motivation for sequencing the genomes of mammals is the resulting ability to help us locate and characterize functional DNA segments shared with humans, we have developed a statistical analysis to quantify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92314d4e3b96365486526bc132969cb3
https://doi.org/10.2202/1544-6115.1065
https://doi.org/10.2202/1544-6115.1065