Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lee A. McDermott"'
Autor:
Ashley T. Fancher, Yun Hua, David A. Close, Wei Xu, Lee A. McDermott, Christopher J. Strock, Ulises Santiago, Carlos J. Camacho, Paul A. Johnston
Publikováno v:
SLAS Discovery, Vol 28, Iss 7, Pp 325-343 (2023)
Three series of compounds were prioritized from a high content screening campaign that identified molecules that blocked dihydrotestosterone (DHT) induced formation of Androgen Receptor (AR) protein-protein interactions (PPIs) with the Transcriptiona
Externí odkaz:
https://doaj.org/article/1f522784d4774c6bb7d40f6419a475d6
Publikováno v:
J Neurotrauma
The purpose of this review is to highlight the pharmacological barrier to drug development for traumatic brain injury (TBI) and to discuss best practice strategies to overcome such barriers. Specifically, this article will review the pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd0d168b8b07f4dc7c3b9bab02e7eb1
https://doi.org/10.1089/neu.2018.6295
https://doi.org/10.1089/neu.2018.6295
Autor:
Shawn K. Milano, Qingqiu Huang, Thuy-Tien T. Nguyen, Sekar Ramachandran, Aaron Finke, Irina Kriksunov, David J. Schuller, D. Marian Szebenyi, Elke Arenholz, Lee A. McDermott, N. Sukumar, Richard A. Cerione, William P. Katt
Publikováno v:
The Journal of Biological Chemistry
Cancer cells frequently exhibit uncoupling of the glycolytic pathway from the TCA cycle (i.e., the “Warburg effect”) and as a result, often become dependent on their ability to increase glutamine catabolism. The mitochondrial enzyme Glutaminase C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa822c06b16d7fdb357d1867222ee3bf
https://pubmed.ncbi.nlm.nih.gov/34954143
https://pubmed.ncbi.nlm.nih.gov/34954143
Autor:
Thuy-Tien T. Nguyen, Sekar Ramachandran, Lee Apostle Mcdermott, Elke Arenholz, Marian Szebenyi, David J. Schuller, A.D. Finke, Irina A. Kriksunov, Qingqiu Huang, Shawn K. Milano, Nagamani Sukumar, Richard A. Cerione, William P. Katt
Many cancer cells become dependent on glutamine metabolism to compensate for glycolysis being uncoupled from the TCA cycle. The mitochondrial enzyme Glutaminase C (GAC) satisfies this ‘glutamine addiction’ by catalyzing the first step in glutamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b821c9abcce32642fbf473fe94ee913a
https://doi.org/10.1101/2021.09.20.461106
https://doi.org/10.1101/2021.09.20.461106
Autor:
Lee Apostle Mcdermott, Clint A. Stalnecker, Richard A. Cerione, William P. Katt, Jason W. O'Neill, Prema Iyer, Qingqiu Huang, Shawn Reimer, Chengliang Zhang
Publikováno v:
Journal of Biological Chemistry. 293:3535-3545
Altered glycolytic flux in cancer cells (the "Warburg effect") causes their proliferation to rely upon elevated glutamine metabolism ("glutamine addiction"). This requirement is met by the overexpression of glutaminase C (GAC), which catalyzes the fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e73666052a4f00743a200dd0e25fc2
https://doi.org/10.1074/jbc.m117.810101
https://doi.org/10.1074/jbc.m117.810101
Publikováno v:
Journal of Biological Chemistry. 293:2606-2616
Profilin 1 (Pfn1) is an important regulator of the actin cytoskeleton and plays a vital role in many actin-based cellular processes. Therefore, identification of a small-molecule intervention strategy targeted against the Pfn1–actin interaction cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615f3cc0622053f22fda3c2331081897
https://doi.org/10.1074/jbc.m117.809137
https://doi.org/10.1074/jbc.m117.809137
Autor:
Diane L. Carlisle, Robert M. Friedlander, Anton Simeonov, Hongchun Li, Murat Can Cobanoglu, Fen Pei, Mark J. Henderson, Andrew M. Stern, Tongying Shun, Timothy R. Lezon, Seyed H Mousavi, D. Lansing Taylor, Steve Titus, Lee Apostle Mcdermott, Michael Fioravanti, Prema Iyer, Mark E. Schurdak, Ivet Bahar, Ajit Jadhav
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75064ea43dd18201b922d197c80331f
http://link.springer.com/article/10.1038/s41598-017-17378-y
http://link.springer.com/article/10.1038/s41598-017-17378-y
Autor:
Alessandro Paiardini, Maurizio Gargano, Francesca Cutruzzolà, Alberto Macone, Valentino Pontecorvi, Lee Apostle Mcdermott, David Ryan Koes, Marina Marani, Alessio Fiascarelli, Tianyi Yang, Roberto Contestabile, Giorgio Giardina, Serena Rinaldo, Alessio Paone
Publikováno v:
'Oncotarget ', vol: 7, pages: 4570-4583 (2016)
ResearcherID
Oncotarget
ResearcherID
Oncotarget
Serine hydroxymethyltransferase (SHMT) is a central enzyme in the metabolic reprogramming of cancer cells, providing activated one-carbon units in the serine-glycine one-carbon metabolism. Previous studies demonstrated that the cytoplasmic isoform of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035b8c9deee52359d3c3153d2b4bfbae
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:46680
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:46680
Autor:
Neil A. Hukriede, Tatiana Novitskaya, Lee Apostle Mcdermott, Mark P. de Caestecker, Ke Xin Zhang, Takuto Chiba, Paisit Paueksakon
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F496-F504
Phenylthiobutanoic acids (PTBAs) are a new class of histone deacetylase (HDAC) inhibitors that accelerate recovery and reduce postinjury fibrosis after ischemia-reperfusion-induced acute kidney injury. However, unlike the more common scenario in whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095a86afa4b66831e9f5350ac07423bf
https://doi.org/10.1152/ajprenal.00534.2013
https://doi.org/10.1152/ajprenal.00534.2013
Autor:
Lee Apostle Mcdermott, Mackenzie Geedy, David Ryan Koes, Shabber Mohammed, Melissa Boby, Richard A. Cerione, William P. Katt, Venkatakrishnan Balasubramanian, Prema Iyer
Publikováno v:
Bioorg Med Chem Lett
Allosteric inhibitors of glutaminase (GAC), such as BPTES, CB-839 and UPGL00019, have great promise as inhibitors of cancer cell growth, but potent inhibitors with drug-like qualities have been difficult to achieve. Here, a small library of GAC inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202b495e82708dc92a32870d8610bc62
https://doi.org/10.1016/j.bmcl.2019.126632
https://doi.org/10.1016/j.bmcl.2019.126632