Zobrazeno 1 - 10
of 1 569
pro vyhledávání: '"Lee A. Denson"'
Autor:
Fatima Zulqarnain, Xueheng Zhao, Kenneth D.R. Setchell, Yash Sharma, Phillip Fernandes, Sanjana Srivastava, Aman Shrivastava, Lubaina Ehsan, Varun Jain, Shyam Raghavan, Christopher Moskaluk, Yael Haberman, Lee A. Denson, Khyati Mehta, Najeeha T. Iqbal, Najeeb Rahman, Kamran Sadiq, Zubair Ahmad, Romana Idress, Junaid Iqbal, Sheraz Ahmed, Aneeta Hotwani, Fayyaz Umrani, Beatrice Amadi, Paul Kelly, Donald E. Brown, Sean R. Moore, Syed Asad Ali, Sana Syed
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110013- (2024)
Summary: Environmental enteric dysfunction (EED) is a subclinical enteropathy challenging to diagnose due to an overlap of tissue features with other inflammatory enteropathies. EED subjects (n = 52) from Pakistan, controls (n = 25), and a validation
Externí odkaz:
https://doaj.org/article/fd58342bfb344c5fb6b60bc3741829b1
Autor:
Katya E. Sosnovski, Tzipi Braun, Amnon Amir, Marina BenShoshan, Haya Abbas-Egbariya, Rakefet Ben-Yishay, Liat Anafi, Camilla Avivi, Iris Barshack, Lee A. Denson, Yael Haberman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Disruption of intestinal epithelial functions is linked to Crohn disease (CD) pathogenesis. We identified a widespread reduction in the expression of long non-coding RNAs (lncRNAs) including LHFPL3-AS2 in the treatment-naïve CD ileum of the
Externí odkaz:
https://doaj.org/article/c1f49afe315c40d5892d2f5b869777b9
Autor:
Tomoaki Ando, Ikuo Takazawa, Zachary T. Spencer, Ryoji Ito, Yoshiaki Tomimori, Zbigniew Mikulski, Kenji Matsumoto, Tohru Ishitani, Lee A. Denson, Yu Kawakami, Yuko Kawakami, Jiro Kitaura, Yashi Ahmed, Toshiaki Kawakami
Publikováno v:
Cells, Vol 13, Iss 11, p 986 (2024)
Crohn’s disease is a chronic, debilitating, inflammatory bowel disease. Here, we report a critical role of phospholipase C-β3 (PLC-β3) in intestinal homeostasis. In PLC-β3-deficient mice, exposure to oral dextran sodium sulfate induced lethality
Externí odkaz:
https://doaj.org/article/4b4c080e7a6f457c9d94b7d7d8bd2086
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/a3420c26fc634c369d2d2e0f29c9274d
Autor:
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Girish Nadkarni, Lee A. Denson, Harry Ostrer, Adam P. Levine, Elena R. Schiff, Anthony W. Segal, Subra Kugathasan, Peter D. Stenson, David N. Cooper, L. Philip Schumm, Scott Snapper, Mark J. Daly, Talin Haritunians, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Steven R. Brant, Dermot P. B. McGovern, Judy H. Cho, Yuval Itan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Inflammatory bowel disease (IBD) is a group of chronic digestive tract inflammatory conditions whose genetic etiology is still poorly understood. The incidence of IBD is particularly high among Ashkenazi Jews. Here, we identify 8 novel and p
Externí odkaz:
https://doaj.org/article/9b4ce2bc11f1400dba2682d34318447c
Autor:
Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith, Subra Kugathasan
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) pati
Externí odkaz:
https://doaj.org/article/775c2f58680944ca846097a854389076
Autor:
Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer, Iris Barshack, Shomron Ben-Horin, Igor Ulitsky, Anthony Beucher, Jorge Ferrer, Jeffrey S. Hyams, Lee A. Denson, Yael Haberman
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Ulcerative colitis (UC), Crohn’s disease (CD), and celiac disease are prevalent intestinal inflammatory disorders with nonsatisfactory therapeutic interventions. Analyzing patient data-driven cohorts can highlight disease pathways and new targets f
Externí odkaz:
https://doaj.org/article/175d48f8e9c64094a115fe7ffb8e26b5
Autor:
Pooja Khandelwal, Dana T Lounder, Allison Bartlett, Yael Haberman, Anil G. Jegga, Sudhir Ghandikota, Jane Koo, Nathan Luebbering, Daniel Leino, Sheyar Abdullah, Michaela Loveless, Phillip Minar, Kelly Lake, Bridget Litts, Rebekah Karns, Adam S. Nelson, Lee A. Denson, Stella M. Davies
Publikováno v:
Haematologica, Vol 108, Iss 7 (2023)
We performed transcriptomic analyses on freshly frozen (n=21) and paraffin-embedded (n=35) gastrointestinal (GI) biopsies from children with and without acute acute GI graft-versus-host disease (GvHD) to study differential gene expressions. We identi
Externí odkaz:
https://doaj.org/article/4fe814e572894a2582f0fd589687275a
Autor:
Ranjit Pelia, Suresh Venkateswaran, Jason D. Matthews, Yael Haberman, David J. Cutler, Jeffrey S. Hyams, Lee A. Denson, Subra Kugathasan
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Crohn’s disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having
Externí odkaz:
https://doaj.org/article/985f433f52b8425b84594cdba42bea7c
Autor:
Sanam Soomro, Suresh Venkateswaran, Kamala Vanarsa, Marwa Kharboutli, Malavika Nidhi, Ramya Susarla, Ting Zhang, Prashanth Sasidharan, Kyung Hyun Lee, Joel Rosh, James Markowitz, Claudia Pedroza, Lee A. Denson, Jeffrey Hyams, Subra Kugathasan, Chandra Mohan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Stool biomarkers hold promise for monitoring disease activity and predicting clinical course in inflammatory bowel disease (IBD) as they originate from the inflamed tissue. Here the authors report an aptamer-based proteomic screen, and discover sever
Externí odkaz:
https://doaj.org/article/0e861c5d16cb448f88bdd0f9eeed0169